CABT-L1914

antibody from Creative Diagnostics

Targeting: ID1 bHLHb24, dJ857M17.1.2

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-L1914

Provider

Creative Diagnostics

Product name

Rabbit Anti-Mouse ID1 monoclonal antibody, Clone 48-3

Antibody type

Monoclonal

Description

There are four members of the Id protein family, Id1, Id2, Id3, and Id4. These proteins were initially discovered as proteins involved in the negative control of cell differentiation. Id proteins act as a negative regulator of transcription through physical interaction with a group of transcription factors known as bHLH (basic helix-loop-helix) proteins. Id proteins interact with bHLH proteins in a manner that prevents DNA binding to the HLH proteins. Because of this activity, the group of proteins were named as Id (for inhibitor of DNA binding). Id proteins have also been found to bind with a number of other proteins such as Rb, Ets, Paz, MIDA-1 and SREBP-1c. Id proteins may play a central role in coordinating gene expression, cell proliferation, tumorigenesis, and angiogenesis. Id proteins have been found to be over-expressed in many types, including Glioblastoma, Medulloblastoma, Neuroblastoma, Pancreatic Cancer, Thyroid Cancer, Squamous Cell Carcinoma, Breast Carcinoma, Endometrial Cancer, Cervical Cancer, Melanoma, and Retinoblastoma. There is a growing body of evidence that Id1 and Id3 play a central role in angiogenesis. Experiments in Id1-/-, Id3-/- knockout mice indicated that with the loss of Id expression there was no vascularization and no subsequent growth of tumors.

Reactivity

Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

Mar-48

Storage

2-8°C. DO NOT FREEZE. Precipitation may occur upon freezing.