11463-1-AP

antibody from Proteintech Group

Targeting: COX4I2 COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2

Provider product page for 11463-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [12]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [2]
Immunohistochemistry [1]

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Product number: 11463-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11463-1-AP, RRID:AB_2085287
Product name: COX4I2 antibody
Antibody type: Polyclonal
Description: KD/KO validated COX4I2 antibody (Cat. #11463-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 150ul

COX4I2 protein structure - 11463-1-AP shown in red.

Submitted references Decreased mixed lineage leukemia 1 is involved in endometriosis-related infertility.

Wen X, Xiong Y, Liu H, Geng T, Jin L, Zhang M, Ma L, Zhang Y
Journal of molecular endocrinology 2021 Jan;66(1):45-57

Acute O₂ sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.

Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P, Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N, López-Barneo J
Science signaling 2020 Jan 21;13(615)

Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment?

Keller G, Binyamin O, Frid K, Saada A, Gabizon R
Neurobiology of disease 2019 Apr;124:57-66

Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia.

Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J
Cell reports 2018 Oct 16;25(3):561-570.e6

Gene expression analyses reveal metabolic specifications in acute O₂ -sensing chemoreceptor cells.

Gao L, Bonilla-Henao V, García-Flores P, Arias-Mayenco I, Ortega-Sáenz P, López-Barneo J
The Journal of physiology 2017 Sep 15;595(18):6091-6120

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit.

Oliva CR, Zhang W, Langford C, Suto MJ, Griguer CE
Oncotarget 2017 Jun 6;8(23):37568-37583

Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.

Aras S, Arrabi H, Purandare N, Hüttemann M, Kamholz J, Züchner S, Grossman LI
Biochimica et biophysica acta. Molecular cell research 2017 Feb;1864(2):440-448

Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas.

Oliva CR, Markert T, Gillespie GY, Griguer CE
Oncotarget 2015 Feb 28;6(6):4330-44

GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.

Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C
Bioconjugate chemistry 2014 Apr 16;25(4):813-23

Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.

Hicks S, Labinskyy N, Piteo B, Laurent D, Mathew JE, Gupte SA, Edwards JG
American journal of physiology. Heart and circulatory physiology 2013 Apr 1;304(7):H903-15

Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.

Schneider L, Giordano S, Zelickson BR, S Johnson M, A Benavides G, Ouyang X, Fineberg N, Darley-Usmar VM, Zhang J
Free radical biology & medicine 2011 Dec 1;51(11):2007-17

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

Oliva CR, Nozell SE, Diers A, McClugage SG 3rd, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A, Griguer CE
The Journal of biological chemistry 2010 Dec 17;285(51):39759-67

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MCF7 cells were subjected to SDS PAGE followed by western blot with 11463-1-AP(COX4I2 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using COX4I2 antibody 11463-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-COX4I2 (IP:11463-1-AP, 3ug; Detection:11463-1-AP 1:1000) with HepG2 cells lysate 8000ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP result of anti-COX4I2 (11463-1-AP for IP and Detection) with HepG2 cell lysate.
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human ovary tumor using 11463-1-AP(COX4I2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue