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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- 13049-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13049-1-AP, RRID:AB_2059000
- Product name
- ARL8B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ARL8B antibody (Cat. #13049-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Specific KIF1A-adaptor interactions control selective cargo recognition.
mTORC1 activity is supported by spatial association with focal adhesions.
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1.
The GTPase Arl8B Plays a Principle Role in the Positioning of Interstitial Axon Branches by Spatially Controlling Autophagosome and Lysosome Location.
The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes.
Hepatitis C virus infection increases autophagosome stability by suppressing lysosomal fusion through an Arl8b-dependent mechanism.
Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.
The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Lysosomal positioning coordinates cellular nutrient responses.
Hummel JJA, Hoogenraad CC
The Journal of cell biology 2021 Oct 4;220(10)
The Journal of cell biology 2021 Oct 4;220(10)
mTORC1 activity is supported by spatial association with focal adhesions.
Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fässler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk VI
The Journal of cell biology 2021 May 3;220(5)
The Journal of cell biology 2021 May 3;220(5)
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Roney JC, Li S, Farfel-Becker T, Huang N, Sun T, Xie Y, Cheng XT, Lin MY, Platt FM, Sheng ZH
Developmental cell 2021 May 17;56(10):1452-1468.e8
Developmental cell 2021 May 17;56(10):1452-1468.e8
ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1.
Keren-Kaplan T, Bonifacino JS
Current biology : CB 2021 Feb 8;31(3):540-554.e5
Current biology : CB 2021 Feb 8;31(3):540-554.e5
The GTPase Arl8B Plays a Principle Role in the Positioning of Interstitial Axon Branches by Spatially Controlling Autophagosome and Lysosome Location.
Adnan G, Rubikaite A, Khan M, Reber M, Suetterlin P, Hindges R, Drescher U
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Oct 14;40(42):8103-8118
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Oct 14;40(42):8103-8118
The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes.
Lu M, van Tartwijk FW, Lin JQ, Nijenhuis W, Parutto P, Fantham M, Christensen CN, Avezov E, Holt CE, Tunnacliffe A, Holcman D, Kapitein L, Schierle GSK, Kaminski CF
Science advances 2020 Dec;6(51)
Science advances 2020 Dec;6(51)
Hepatitis C virus infection increases autophagosome stability by suppressing lysosomal fusion through an Arl8b-dependent mechanism.
Jones-Jamtgaard KN, Wozniak AL, Koga H, Ralston R, Weinman SA
The Journal of biological chemistry 2019 Sep 27;294(39):14257-14266
The Journal of biological chemistry 2019 Sep 27;294(39):14257-14266
Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.
Farfel-Becker T, Roney JC, Cheng XT, Li S, Cuddy SR, Sheng ZH
Cell reports 2019 Jul 2;28(1):51-64.e4
Cell reports 2019 Jul 2;28(1):51-64.e4
The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.
Schiefermeier N, Scheffler JM, de Araujo ME, Stasyk T, Yordanov T, Ebner HL, Offterdinger M, Munck S, Hess MW, Wickström SA, Lange A, Wunderlich W, Fässler R, Teis D, Huber LA
The Journal of cell biology 2014 May 26;205(4):525-40
The Journal of cell biology 2014 May 26;205(4):525-40
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Kaniuk NA, Canadien V, Bagshaw RD, Bakowski M, Braun V, Landekic M, Mitra S, Huang J, Heo WD, Meyer T, Pelletier L, Andrews-Polymenis H, McClelland M, Pawson T, Grinstein S, Brumell JH
Cellular microbiology 2011 Nov;13(11):1812-23
Cellular microbiology 2011 Nov;13(11):1812-23
Lysosomal positioning coordinates cellular nutrient responses.
Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC
Nature cell biology 2011 Apr;13(4):453-60
Nature cell biology 2011 Apr;13(4):453-60
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 13049-1-AP( ARL8B Antibody) at dilution of 1:1000
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- fetal human brain tissue were subjected to SDS PAGE followed by western blot with 13049-1-AP( ARL8B Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ARL8B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ARL8B. This antibody recognizes human,mouse,rat antigen. The ARL8B antibody has been validated for the following applications: ELISA, IHC, WB analysis.
