Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [3]
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Validation data
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- Product number
- NBP1-82553 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-82553, RRID:AB_11023606
- Product name
- Rabbit Polyclonal NKX6.1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human NKX6.1 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling.
In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress.
The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation.
Point mutations in the PDX1 transactivation domain impair human β-cell development and function.
Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.
Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells.
Identification of proliferative and mature β-cells in the islets of Langerhans.
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.
Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.
Legøy TA, Vethe H, Abadpour S, Strand BL, Scholz H, Paulo JA, Ræder H, Ghila L, Chera S
Scientific reports 2020 Jan 15;10(1):414
Scientific reports 2020 Jan 15;10(1):414
In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress.
Legøy TA, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S
Acta physiologica (Oxford, England) 2020 Apr;228(4):e13433
Acta physiologica (Oxford, England) 2020 Apr;228(4):e13433
The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation.
Vethe H, Ghila L, Berle M, Hoareau L, Haaland ØA, Scholz H, Paulo JA, Chera S, Ræder H
Frontiers in endocrinology 2019;10:293
Frontiers in endocrinology 2019;10:293
Point mutations in the PDX1 transactivation domain impair human β-cell development and function.
Wang X, Sterr M, Ansarullah, Burtscher I, Böttcher A, Beckenbauer J, Siehler J, Meitinger T, Häring HU, Staiger H, Cernilogar FM, Schotta G, Irmler M, Beckers J, Wright CVE, Bakhti M, Lickert H
Molecular metabolism 2019 Jun;24:80-97
Molecular metabolism 2019 Jun;24:80-97
Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.
Wang X, Malinowski AR, Beckenbauer J, Siehler J, Blöchinger A, Meitinger T, Häring HU, Staiger H, Burtscher I, Lickert H
Stem cell research 2019 Aug;39:101531
Stem cell research 2019 Aug;39:101531
Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells.
Vethe H, Bjørlykke Y, Ghila LM, Paulo JA, Scholz H, Gygi SP, Chera S, Ræder H
Scientific reports 2017 Jul 6;7(1):4780
Scientific reports 2017 Jul 6;7(1):4780
Identification of proliferative and mature β-cells in the islets of Langerhans.
Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H
Nature 2016 Jul 21;535(7612):430-4
Nature 2016 Jul 21;535(7612):430-4
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.
Pasquali L, Gaulton KJ, Rodríguez-Seguí SA, Mularoni L, Miguel-Escalada I, Akerman İ, Tena JJ, Morán I, Gómez-Marín C, van de Bunt M, Ponsa-Cobas J, Castro N, Nammo T, Cebola I, García-Hurtado J, Maestro MA, Pattou F, Piemonti L, Berney T, Gloyn AL, Ravassard P, Skarmeta JLG, Müller F, McCarthy MI, Ferrer J
Nature genetics 2014 Feb;46(2):136-143
Nature genetics 2014 Feb;46(2):136-143
Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.
Fiori JL, Shin YK, Kim W, Krzysik-Walker SM, González-Mariscal I, Carlson OD, Sanghvi M, Moaddel R, Farhang K, Gadkaree SK, Doyle ME, Pearson KJ, Mattison JA, de Cabo R, Egan JM
Diabetes 2013 Oct;62(10):3500-13
Diabetes 2013 Oct;62(10):3500-13
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: NKX6.1 Antibody [NBP1-82553] - Analysis in human cell line HEK 293.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NKX6.1 Antibody [NBP1-82553] - Immunohistochemical staining of human pancreas shows strong nuclear positivity in islets of Langerhans.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NKX6.1 Antibody [NBP1-82553] - Staining of human liver shows no positivity as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NKX6.1 Antibody [NBP1-82553] - Staining of human colon shows no positivity in glandular cells as expected.