CABT-B1847

FBXO7 antibody from Creative Diagnostics
Fbx, FBX7, PARK15
Western blot
Recommended by provider
Immunocytochemistry
Recommended by provider
Immunohistochemistry
Recommended by provider

Antibody data

Product number
CABT-B1847
Provider
Creative Diagnostics
Product name
Anti-FBXO7 polyclonal antibody
Provider product page
Creative Diagnostics - CABT-B1847
Antibody type
Polyclonal
Description
F-box only protein 7 (UniProt Q9Y3I1) is encoded by the FBXO7 (Also known as FBX, FBX7, PKPS, FBX07, PARK15) gene in human (Gene ID 25793). The Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligase complexes rely on their F-box protein component for substrate recognition. In addition to Fbxs, to which Fbxo7 belongs, there exist two other classes of F-box proteins, Fbws and Fbls. Fbxo7 recruits substrate via its C-terminal proline rich domain and associates with the adapter protein Skp1 via its F-box domain. In addition to mediating SCF-dependent ubiquitination, Fbxo7 is also involved in SCF-independent activities. Fbxo7 is reported to participate in autophagic clearance of damaged mitochondria (mitophagy) in response to mitochondrial depolarisation through direct interaction with PINK1 (PARK6) and Parkin (PARK2), while Parkinsons disease-associated Fbxo7 mutations affect Parkin mitochondrial translocation and Parkin-mediated mitophagy.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 _g
Concentration
Please refer to lot specific datasheet.
Storage
Stable for 1 year at 2-8°C from date of receipt.
Provider Type Product Number
- No reagents -