LARGE1

gene product
KIAA0609, LARGE
This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
164 antibodies from 27 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
28 antibodies
antibodies-online
35 antibodies
Invitrogen Antibodies
5 antibodies
GeneTex
3 antibodies
OriGene
4 antibodies
Proteintech Group
1 antibody
Antibodies.com
3 antibodies
Abiocode, Inc.
1 antibody
NovoPro Bioscience Inc.
1 antibody
Acris Antibodies GmbH
3 antibodies
LifeSpan BioSciences, Inc.
21 antibodies
Biorbyt
4 antibodies
NSJ Bioreagents
2 antibodies
Everest Biotech
2 antibodies
Aviva Systems Biology
3 antibodies
Abnova Corporation
4 antibodies
Abgent
2 antibodies
Arigo
1 antibody
St John's Laboratory
3 antibodies
ProSci
3 antibodies
Abbexa
2 antibodies
Creative Diagnostics
3 antibodies
MyBioSource
2 antibodies
Sigma-Aldrich
1 antibody
United States Biological
24 antibodies
Leading Biology
2 antibodies
Creative Biolabs
1 antibody