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Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB555-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse TSLP Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse TSLP in Western blots.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Antigen sequence
Q9JIE6- Isotype
- IgG
- Antibody clone number
- 152614
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9+ and IL-13+ type 2 innate lymphoid cell subpopulations.
Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response.
Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response.
Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect of Di-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model.
Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease.
Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1α/IL-6 loop.
Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.
Thymic stromal lymphopoietin is a key mediator of breast cancer progression.
IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.
Peroxisome proliferator-activated receptor γ-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice.
Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation.
A mechanism for the initiation of allergen-induced T helper type 2 responses.
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Verma M, Liu S, Michalec L, Sripada A, Gorska MM, Alam R
The Journal of allergy and clinical immunology 2018 Sep;142(3):793-803.e8
The Journal of allergy and clinical immunology 2018 Sep;142(3):793-803.e8
Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response.
Cao Y, Zhang E, Yang J, Yang Y, Yu J, Xiao Y, Li W, Zhou D, Li Y, Zhao B, Yan H, Lu M, Zhong M, Yan H
Journal of leukocyte biology 2017 Sep;102(3):575-587
Journal of leukocyte biology 2017 Sep;102(3):575-587
Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response.
Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF, Kiyono H
Mucosal immunology 2017 Jul;10(4):901-911
Mucosal immunology 2017 Jul;10(4):901-911
Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect of Di-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model.
You H, Li R, Wei C, Chen S, Mao L, Zhang Z, Yang X
PloS one 2016;11(7):e0159479
PloS one 2016;11(7):e0159479
Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease.
Yu M, Owens DM, Ghosh S, Farber DL
The Journal of investigative dermatology 2015 Nov;135(11):2688-2696
The Journal of investigative dermatology 2015 Nov;135(11):2688-2696
Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1α/IL-6 loop.
Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, Suzuki S, Inamitsu M, Yamamoto KI, Simmons O, Toda S, Conway SJ, Hamasaki Y, Izuhara K
The Journal of investigative dermatology 2014 May;134(5):1295-1304
The Journal of investigative dermatology 2014 May;134(5):1295-1304
Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.
Cipolat S, Hoste E, Natsuga K, Quist SR, Watt FM
eLife 2014 May 5;3:e01888
eLife 2014 May 5;3:e01888
Thymic stromal lymphopoietin is a key mediator of breast cancer progression.
Olkhanud PB, Rochman Y, Bodogai M, Malchinkhuu E, Wejksza K, Xu M, Gress RE, Hesdorffer C, Leonard WJ, Biragyn A
Journal of immunology (Baltimore, Md. : 1950) 2011 May 15;186(10):5656-62
Journal of immunology (Baltimore, Md. : 1950) 2011 May 15;186(10):5656-62
IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.
Oh MH, Oh SY, Yu J, Myers AC, Leonard WJ, Liu YJ, Zhu Z, Zheng T
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 15;186(12):7232-42
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 15;186(12):7232-42
Peroxisome proliferator-activated receptor γ-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice.
Jung K, Tanaka A, Fujita H, Matsuda A, Oida K, Karasawa K, Okamoto N, Ohmori K, Jee Y, Shin T, Matsuda H
The Journal of allergy and clinical immunology 2011 Feb;127(2):420-429.e1-6
The Journal of allergy and clinical immunology 2011 Feb;127(2):420-429.e1-6
Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation.
Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A
European journal of immunology 2009 Nov;39(11):3078-83
European journal of immunology 2009 Nov;39(11):3078-83
A mechanism for the initiation of allergen-induced T helper type 2 responses.
Sokol CL, Barton GM, Farr AG, Medzhitov R
Nature immunology 2008 Mar;9(3):310-8
Nature immunology 2008 Mar;9(3):310-8
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
Blood 2007 May 1;109(9):3706-12
Blood 2007 May 1;109(9):3706-12
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by TSLP and Neutralization by Mouse TSLP Antibody. Recombinant Mouse TSLP (Catalog # 555-TS) stimulates proliferation in the BaF3 mouse pro-B cell line transfected with mouse IL-7 R alpha in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse TSLP (7.5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse TSLP Monoclonal Antibody (Catalog # MAB555). The ND50 is typically 0.1-0.4 µg/mL.
