AMM00172G

antibody from Leading Biology
Targeting: CD1A CD1
Provider product page for AMM00172G
Western blot
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry
Flow cytometry

Antibody data

Product number
AMM00172G - Provider product page
Provider
Leading Biology
Product name
CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide
Antibody type
Monoclonal
Description
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
Reactivity
Human
Host
Mouse
Isotype
IgG
Antibody clone number
O10
Storage
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
CD1A protein structure - AMM00172G shown in red.