300101

antibody from BioLegend

Targeting: CD1A CD1

Immunohistochemistry (Recommended by provider)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

300101

Provider

BioLegend

Proper citation

BioLegend Cat#300101, RRID:AB_314015

Product name

Purified anti-human CD1a

Antibody type

Monoclonal

Antigen

CD1a

Description

CD1a is a 49 kD member of the immunoglobulin superfamily also known as T6 and R4. It is a type I membrane glycoprotein with structural similarities to MHC class I and is non-covalently associated with β2-microglobulin. CD1a plays a role in non-peptide glycolipid antigen presentation to CD1-restricted T cells. It is expressed on cortical double positive and single positive thymocytes, Langerhans cells, and dendritic cells. In addition to antigen presentation, CD1a has been implicated in thymic T cell development.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

25 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C.

References

Submitted references

Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells.

Curti A, Trabanelli S, Onofri C, Aluigi M, Salvestrini V, Ocadlikova D, Evangelisti C, Rutella S, De Cristofaro R, Ottaviani E, Baccarani M, Lemoli RM
Haematologica 2010 Dec;95(12):2022-30

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Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals.

Patton KM, McGuire TC, Hines MT, Mealey RH, Hines SA
Infection and immunity 2005 Apr;73(4):2083-93

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human T lymphoblastic leukemia cell line Molt-4 stained with purified HI149, followed by anti-mouse IgGs FITC

Conjugate

Unconjugated