Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10802-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10802-1-AP, RRID:AB_2110945
- Product name
- Geminin antibody
- Antibody type
- Polyclonal
- Description
- Geminin antibody (Cat. #10802-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Basal expression of RAD51 foci predicts olaparib response in patient-derived ovarian cancer xenografts.
Lysophosphatidic Acid-Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase.
Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells.
Clinical consequences of BRCA2 hypomorphism.
Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity.
The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks.
Association of RAD51 with homologous recombination deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial.
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks.
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers.
BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers.
Cell Cycle Analysis and Relevance for Single-Cell Gating in Mass Cytometry.
Immunohistochemical assessment of chromatin licensing and DNA replication factor 1, geminin, and γ-H2A.X in oral epithelial precursor lesions and squamous cell carcinoma.
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.
Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder.
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines.
In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.
Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest.
The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.
APC/CCDC20 and APC/C play pivotal roles in the process of embryonic development in Artemia sinica.
Cell cycle kinetic analysis of colorectal neoplasms using a new automated immunohistochemistry-based cell cycle detection method.
Whole genomes redefine the mutational landscape of pancreatic cancer.
Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma.
Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.
A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.
Guffanti F, Alvisi MF, Anastasia A, Ricci F, Chiappa M, Llop-Guevara A, Serra V, Fruscio R, Degasperi A, Nik-Zainal S, Bani MR, Lupia M, Giavazzi R, Rulli E, Damia G
British journal of cancer 2022 Jan;126(1):120-128
British journal of cancer 2022 Jan;126(1):120-128
Lysophosphatidic Acid-Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase.
Zhao H, Gezi G, Tian X, Jia P, Morigen M, Fan L
Frontiers in pharmacology 2021;12:706240
Frontiers in pharmacology 2021;12:706240
Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells.
Hintelmann K, Berenz T, Kriegs M, Christiansen S, Gatzemeier F, Struve N, Petersen C, Betz C, Rothkamm K, Oetting A, Rieckmann T
Frontiers in oncology 2021;11:683688
Frontiers in oncology 2021;11:683688
Clinical consequences of BRCA2 hypomorphism.
Castells-Roca L, Gutiérrez-Enríquez S, Bonache S, Bogliolo M, Carrasco E, Aza-Carmona M, Montalban G, Muñoz-Subirana N, Pujol R, Cruz C, Llop-Guevara A, Ramírez MJ, Saura C, Lasa A, Serra V, Diez O, Balmaña J, Surrallés J
NPJ breast cancer 2021 Sep 9;7(1):117
NPJ breast cancer 2021 Sep 9;7(1):117
Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity.
Ippati S, Deng Y, van der Hoven J, Heu C, van Hummel A, Chua SW, Paric E, Chan G, Feiten A, Fath T, Ke YD, Haass NK, Ittner LM
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 23;118(12)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 23;118(12)
The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks.
van Wijk LM, Kramer CJH, Vermeulen S, Ter Haar NT, de Jonge MM, Kroep JR, de Kroon CD, Gaarenstroom KN, Vrieling H, Bosse T, Vreeswijk MPG
Cancers 2021 Jun 15;13(12)
Cancers 2021 Jun 15;13(12)
Association of RAD51 with homologous recombination deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial.
Llop-Guevara A, Loibl S, Villacampa G, Vladimirova V, Schneeweiss A, Karn T, Zahm DM, Herencia-Ropero A, Jank P, van Mackelenbergh M, Fasching PA, Marmé F, Stickeler E, Schem C, Dienstmann R, Florian S, Nekljudova V, Balmaña J, Hahnen E, Denkert C, Serra V
Annals of oncology : official journal of the European Society for Medical Oncology 2021 Dec;32(12):1590-1596
Annals of oncology : official journal of the European Society for Medical Oncology 2021 Dec;32(12):1590-1596
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.
Gerakopoulos V, Ngo P, Tsiokas L
Life science alliance 2020 Sep;3(9)
Life science alliance 2020 Sep;3(9)
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
van Wijk LM, Vermeulen S, Meijers M, van Diest MF, Ter Haar NT, de Jonge MM, Solleveld-Westerink N, van Wezel T, van Gent DC, Kroep JR, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG
Cancers 2020 Sep 29;12(10)
Cancers 2020 Sep 29;12(10)
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks.
Rother MB, Pellegrino S, Smith R, Gatti M, Meisenberg C, Wiegant WW, Luijsterburg MS, Imhof R, Downs JA, Vertegaal ACO, Huet S, Altmeyer M, van Attikum H
Nature communications 2020 Nov 13;11(1):5775
Nature communications 2020 Nov 13;11(1):5775
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
Chopra N, Tovey H, Pearson A, Cutts R, Toms C, Proszek P, Hubank M, Dowsett M, Dodson A, Daley F, Kriplani D, Gevensleben H, Davies HR, Degasperi A, Roylance R, Chan S, Tutt A, Skene A, Evans A, Bliss JM, Nik-Zainal S, Turner NC
Nature communications 2020 May 29;11(1):2662
Nature communications 2020 May 29;11(1):2662
RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers.
Krais JJ, Wang Y, Bernhardy AJ, Clausen E, Miller JA, Cai KQ, Scott CL, Johnson N
Cancer research 2020 Jul 1;80(13):2848-2860
Cancer research 2020 Jul 1;80(13):2848-2860
BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers.
Coussy F, El-Botty R, Château-Joubert S, Dahmani A, Montaudon E, Leboucher S, Morisset L, Painsec P, Sourd L, Huguet L, Nemati F, Servely JL, Larcher T, Vacher S, Briaux A, Reyes C, La Rosa P, Lucotte G, Popova T, Foidart P, Sounni NE, Noel A, Decaudin D, Fuhrmann L, Salomon A, Reyal F, Mueller C, Ter Brugge P, Jonkers J, Poupon MF, Stern MH, Bièche I, Pommier Y, Marangoni E
Science translational medicine 2020 Feb 19;12(531)
Science translational medicine 2020 Feb 19;12(531)
Cell Cycle Analysis and Relevance for Single-Cell Gating in Mass Cytometry.
Rein ID, Notø HØ, Bostad M, Huse K, Stokke T
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2020 Aug;97(8):832-844
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2020 Aug;97(8):832-844
Immunohistochemical assessment of chromatin licensing and DNA replication factor 1, geminin, and γ-H2A.X in oral epithelial precursor lesions and squamous cell carcinoma.
Siril YJ, Kouketsu A, Oikawa M, Takahashi T, Kumamoto H
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Nov;48(10):888-896
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Nov;48(10):888-896
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, Ponsioen B, Ho VWH, Neel BG, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG, van Diest PJ, Witteveen PO, Jonges T, Bos JL, van Oudenaarden A, Zweemer RP, Snippert HJG, Kloosterman WP, Clevers H
Nature medicine 2019 May;25(5):838-849
Nature medicine 2019 May;25(5):838-849
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Brandsma I, Sato K, van Rossum-Fikkert SE, van Vliet N, Sleddens E, Reuter M, Odijk H, van den Tempel N, Dekkers DHW, Bezstarosti K, Demmers JAA, Maas A, Lebbink J, Wyman C, Essers J, van Gent DC, Baarends WM, Knipscheer P, Kanaar R, Zelensky AN
Cell reports 2019 Jun 25;27(13):3790-3798.e7
Cell reports 2019 Jun 25;27(13):3790-3798.e7
Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.
Venneker S, Kruisselbrink AB, Briaire-de Bruijn IH, de Jong Y, van Wijnen AJ, Danen EHJ, Bovée JVMG
Cancers 2019 Dec 2;11(12)
Cancers 2019 Dec 2;11(12)
Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder.
van den Tempel N, Naipal KAT, Raams A, van Gent DC, Franckena M, Boormans JL, Kanaar R
PloS one 2018;13(12):e0209101
PloS one 2018;13(12):e0209101
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N
Cell reports 2018 Sep 25;24(13):3513-3527.e7
Cell reports 2018 Sep 25;24(13):3513-3527.e7
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
Castroviejo-Bermejo M, Cruz C, Llop-Guevara A, Gutiérrez-Enríquez S, Ducy M, Ibrahim YH, Gris-Oliver A, Pellegrino B, Bruna A, Guzmán M, Rodríguez O, Grueso J, Bonache S, Moles-Fernández A, Villacampa G, Viaplana C, Gómez P, Vidal M, Peg V, Serres-Créixams X, Dellaire G, Simard J, Nuciforo P, Rubio IT, Dienstmann R, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Déas O, Jonkers J, Masson JY, Cairo S, Judde JG, O'Connor MJ, Díez O, Balmaña J, Serra V
EMBO molecular medicine 2018 Dec;10(12)
EMBO molecular medicine 2018 Dec;10(12)
Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines.
Fleury H, Carmona E, Morin VG, Meunier L, Masson JY, Tonin PN, Provencher D, Mes-Masson AM
Oncotarget 2017 Jun 20;8(25):40152-40168
Oncotarget 2017 Jun 20;8(25):40152-40168
In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.
Chatalic KL, Konijnenberg M, Nonnekens J, de Blois E, Hoeben S, de Ridder C, Brunel L, Fehrentz JA, Martinez J, van Gent DC, Nock BA, Maina T, van Weerden WM, de Jong M
Theranostics 2016;6(1):104-17
Theranostics 2016;6(1):104-17
Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.
Cheng F, Twardowski L, Reifenberg K, Winter K, Canisius A, Pross E, Fan J, Schmitt E, Shultz LD, Lackner KJ, Torzewski M
PloS one 2016;11(8):e0157311
PloS one 2016;11(8):e0157311
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
Bhide SA, Thway K, Lee J, Wong K, Clarke P, Newbold KL, Nutting CM, Harrington KJ
British journal of cancer 2016 Sep 27;115(7):825-30
British journal of cancer 2016 Sep 27;115(7):825-30
Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest.
Schaaf L, Schwab M, Ulmer C, Heine S, Mürdter TE, Schmid JO, Sauer G, Aulitzky WE, van der Kuip H
Cancer research 2016 May 15;76(10):2868-75
Cancer research 2016 May 15;76(10):2868-75
The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.
Wang Y, Bernhardy AJ, Cruz C, Krais JJ, Nacson J, Nicolas E, Peri S, van der Gulden H, van der Heijden I, O'Brien SW, Zhang Y, Harrell MI, Johnson SF, Candido Dos Reis FJ, Pharoah PD, Karlan B, Gourley C, Lambrechts D, Chenevix-Trench G, Olsson H, Benitez JJ, Greene MH, Gore M, Nussbaum R, Sadetzki S, Gayther SA, Kjaer SK, kConFab Investigators, D'Andrea AD, Shapiro GI, Wiest DL, Connolly DC, Daly MB, Swisher EM, Bouwman P, Jonkers J, Balmaña J, Serra V, Johnson N
Cancer research 2016 May 1;76(9):2778-90
Cancer research 2016 May 1;76(9):2778-90
APC/CCDC20 and APC/C play pivotal roles in the process of embryonic development in Artemia sinica.
Zhang M, Yao F, Luan H, Zhao W, Jing T, Zhang S, Hou L, Zou X
Scientific reports 2016 Dec 19;6:39047
Scientific reports 2016 Dec 19;6:39047
Cell cycle kinetic analysis of colorectal neoplasms using a new automated immunohistochemistry-based cell cycle detection method.
Tomono A, Itoh T, Yanagita E, Imagawa N, Kakeji Y
Medicine 2015 Jan;94(4):e501
Medicine 2015 Jan;94(4):e501
Whole genomes redefine the mutational landscape of pancreatic cancer.
Waddell N, Pajic M, Patch AM, Chang DK, Kassahn KS, Bailey P, Johns AL, Miller D, Nones K, Quek K, Quinn MC, Robertson AJ, Fadlullah MZ, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, Manning S, Nourse C, Nourbakhsh E, Wani S, Wilson PJ, Markham E, Cloonan N, Anderson MJ, Fink JL, Holmes O, Kazakoff SH, Leonard C, Newell F, Poudel B, Song S, Taylor D, Waddell N, Wood S, Xu Q, Wu J, Pinese M, Cowley MJ, Lee HC, Jones MD, Nagrial AM, Humphris J, Chantrill LA, Chin V, Steinmann AM, Mawson A, Humphrey ES, Colvin EK, Chou A, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Pettitt JA, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N, Jamieson NB, Graham JS, Niclou SP, Bjerkvig R, Grützmann R, Aust D, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Falconi M, Zamboni G, Tortora G, Tempero MA, Australian Pancreatic Cancer Genome Initiative, Gill AJ, Eshleman JR, Pilarsky C, Scarpa A, Musgrove EA, Pearson JV, Biankin AV, Grimmond SM
Nature 2015 Feb 26;518(7540):495-501
Nature 2015 Feb 26;518(7540):495-501
Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma.
Cates JM, Memoli VA, Gonzalez RS
Virchows Archiv : an international journal of pathology 2015 Aug;467(2):211-6
Virchows Archiv : an international journal of pathology 2015 Aug;467(2):211-6
Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.
Naipal KA, Verkaik NS, Ameziane N, van Deurzen CH, Ter Brugge P, Meijers M, Sieuwerts AM, Martens JW, O'Connor MJ, Vrieling H, Hoeijmakers JH, Jonkers J, Kanaar R, de Winter JP, Vreeswijk MP, Jager A, van Gent DC
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Sep 15;20(18):4816-26
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Sep 15;20(18):4816-26
A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.
Graeser M, McCarthy A, Lord CJ, Savage K, Hills M, Salter J, Orr N, Parton M, Smith IE, Reis-Filho JS, Dowsett M, Ashworth A, Turner NC
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Dec 15;16(24):6159-68
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Dec 15;16(24):6159-68
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human testis tissue were subjected to SDS PAGE followed by western blot with 10802-1-AP(GMNN antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-GMNN (IP:10802-1-AP, 4ug; Detection:10802-1-AP 1:1000) with HEK-293 cells lysate 4500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Geminin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Geminin. This antibody recognizes human,mouse,rat antigen. The Geminin antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.