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Protein structure
RNF111
Ring finger protein 111ARK, Arkadia, DKFZP761D081, FLJ38008
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Top validated antibodies |
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| Novus Biologicals |  H00054778-M05 |
11 references | Monoclonal |
WB
EL
ICC
BN
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| Abnova Corporation | H00054778-M05 |
9 references | Monoclonal |
WB
EL
ICC
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| antibodies-online | ABIN527194 |
9 references | Monoclonal |
WB
EL
ICC
|
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| Invitrogen Antibodies | PA5-58449 |
1 references | Polyclonal |
WB
ICC
IHC
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| Atlas Antibodies | HPA038576 |
1 references | Polyclonal |
ICC
IHC
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