BS8592

antibody from Bioworld Technology, Inc
Targeting: AFF1 AF-4, AF4, MLLT2, PBM1
Provider product page for BS8592
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8592 - Provider product page
Provider
Bioworld Technology, Inc
Product name
AFF1 polyclonal antibody
Antibody type
Polyclonal
Antigen
AF4/FMR2 family member 1; ALL1-fused gene from chromosome 4 protein; Protein AF-4; Protein FEL; Proto-oncogene AF4; AFF1; AF4, FEL, MLLT2, PBM1
Description
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
AFF1 protein structure - BS8592 shown in red.