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Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [2]
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Validation data
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- Product number
- ABIN500861 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-ADAM Metallopeptidase Domain 17 (ADAM17) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- TACE antibody was raised against a peptide corresponding to amino acids near the carboxyterminus of human CD156b / ADAM17. Remarks: This sequence differs from those of mouse and rat TACE by one amino acid.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeatedfreezing and thawing. Shelf life: one year from despatch.
Submitted references cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter.
Targets in cytokine activation.
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.
An essential role for ectodomain shedding in mammalian development.
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.
Mizui Y, Yamazaki K, Sagane K, Tanaka I
Gene 1999 Jun 11;233(1-2):67-74
Gene 1999 Jun 11;233(1-2):67-74
Targets in cytokine activation.
Giegel DA, Chaplin DD
Agents and actions. Supplements 1998;49:1-3
Agents and actions. Supplements 1998;49:1-3
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.
Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP, Black RA
The Journal of biological chemistry 1998 Oct 23;273(43):27765-7
The Journal of biological chemistry 1998 Oct 23;273(43):27765-7
An essential role for ectodomain shedding in mammalian development.
Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA
Science (New York, N.Y.) 1998 Nov 13;282(5392):1281-4
Science (New York, N.Y.) 1998 Nov 13;282(5392):1281-4
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Becherer JD
Nature 1997 Feb 20;385(6618):733-6
Nature 1997 Feb 20;385(6618):733-6
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.
Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolfson MF, Castner BJ, Stocking KL, Reddy P, Srinivasan S, Nelson N, Boiani N, Schooley KA, Gerhart M, Davis R, Fitzner JN, Johnson RS, Paxton RJ, March CJ, Cerretti DP
Nature 1997 Feb 20;385(6618):729-33
Nature 1997 Feb 20;385(6618):729-33
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of TACE in HeLa (1,3) and Jurkat (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide with TACE Antibody Cat.-No AP30854PU-N at 1 ?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunocytochemistry of TACE in HeLa cells with TACE Antibody AP30854PU-N at 10 μg/ml.
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunofluorescence of TACE in HeLa cells with TACE Antibody AP30854PU-N at 10 μg/ml.
