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- Product number
- PA5-67816 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- TMEM106C Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- Predicted to react with Mouse and Rat samples.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 µL
- Concentration
- 1 mg/mL
- Storage
- -20°C
Submitted references LINC00238 inhibits hepatic carcinoma progression by activating TMEM106C‑mediated apoptosis pathway.
Jiang C, Li F, Yang M, Duan J, Lai J, Sun S, Fan S
Molecular medicine reports 2021 Nov;24(5)
Molecular medicine reports 2021 Nov;24(5)
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Figure 3. LINC00238 negatively regulates the expression of TMEM106C in HCC. (A) The predicted result of LncTar showed that MEM106C was a target gene of LINC00238. A dot in the graph indicates there is a paired of bases in the two sequences. A line in the graph indicates there is a paired of complementary bases in the two sequences. (B) The data of RNA immunoprecipitation assay showed that TMEM106C was a target of LINC00238 in HCCLM3 and MHCC-97h cells. (C) The western blot results showed that protein expression of TMEM106C in HCC cells was decreased by LINC00238 overexpression. (D) Scatter plots comparing TMEM106C expression in HCC samples (n=396) and normal tissue samples (n=160) showed that TMEM106C was upregulated in HCC tumor samples compared with normal samples. (E) Kaplan-Meier analysis indicated a correlation between high TMEM106 and poor overall survival rates in patients with HCC. (F) Correlation analysis between LINC00238 and TMEM106C expression showed that the LINC00238 expression was negatively correlated with TMEM106C expression. (G) RT-qPCR data showed that TMEM106C expression was upregulated in HCC tumor tissues compared with corresponding normal tissues. *P
