Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5965 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- TNFÏ« IP8 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 71-116 of Human TNFÏ«-IP83.
- Description
- TNFÏ«-IP 8 (tumor necrosis factor, Ï«-induced protein 8), also known as NF°ÙB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NF°ÙB and TNF. The induction of TNFÏ«-IP 8 by TNF is dependent on the activation of NF°ÙB. TNFÏ«-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFÏ«-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFÏ«-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFÏ«-IP 8 is present as three isoforms produced by alternative splicing.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of TNF¦Á-IP8 pAb at 1:500 dilutionLane1:HEK293T cell lysateLane2:Raw264.7 cell lysateLane3:H9C2 cell lysate