BS5965

antibody from Bioworld Technology, Inc
Targeting: TNFAIP8 GG2-1, MDC-3.13, SCC-S2
Provider product page for BS5965
Western blot
Immunocytochemistry

Antibody data

Product number
BS5965 - Provider product page
Provider
Bioworld Technology, Inc
Product name
TNFÏ« IP8 polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 71-116 of Human TNFÏ«-IP83.
Description
TNFÏ«-IP 8 (tumor necrosis factor, Ï«-induced protein 8), also known as NF°ÙB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NF°ÙB and TNF. The induction of TNFÏ«-IP 8 by TNF is dependent on the activation of NF°ÙB. TNFÏ«-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFÏ«-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFÏ«-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFÏ«-IP 8 is present as three isoforms produced by alternative splicing.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TNFAIP8 protein structure - BS5965 shown in red.