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- Product number
- NBP1-90300 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-90300, RRID:AB_11029326
- Product name
- Rabbit Polyclonal beta Sarcoglycan Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human beta Sarcoglycan antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy.
Systemic AAV-Mediated β-Sarcoglycan Delivery Targeting Cardiac and Skeletal Muscle Ameliorates Histological and Functional Deficits in LGMD2E Mice.
Thrombospondin expression in myofibers stabilizes muscle membranes.
β-Sarcoglycan gene transfer decreases fibrosis and restores force in LGMD2E mice.
Brody MJ, Vanhoutte D, Schips TG, Boyer JG, Bakshi CV, Sargent MA, York AJ, Molkentin JD
Molecular and cellular biology 2018 Jul 15;38(14)
Molecular and cellular biology 2018 Jul 15;38(14)
Systemic AAV-Mediated β-Sarcoglycan Delivery Targeting Cardiac and Skeletal Muscle Ameliorates Histological and Functional Deficits in LGMD2E Mice.
Pozsgai ER, Griffin DA, Heller KN, Mendell JR, Rodino-Klapac LR
Molecular therapy : the journal of the American Society of Gene Therapy 2017 Apr 5;25(4):855-869
Molecular therapy : the journal of the American Society of Gene Therapy 2017 Apr 5;25(4):855-869
Thrombospondin expression in myofibers stabilizes muscle membranes.
Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Yi H, Gao QQ, Rabinowitz JE, Volk T, McNally EM, Molkentin JD
eLife 2016 Sep 26;5
eLife 2016 Sep 26;5
β-Sarcoglycan gene transfer decreases fibrosis and restores force in LGMD2E mice.
Pozsgai ER, Griffin DA, Heller KN, Mendell JR, Rodino-Klapac LR
Gene therapy 2016 Jan;23(1):57-66
Gene therapy 2016 Jan;23(1):57-66
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: beta Sarcoglycan Antibody [NBP1-90300] - Staining of human heart muscle shows high expression.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: beta Sarcoglycan Antibody [NBP1-90300] - Staining of human lymph node shows low expression as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: beta Sarcoglycan Antibody [NBP1-90300] - Staining of human heart muscle shows strong membranous and cytoplasmic positivity in cardiomyocytes.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: beta Sarcoglycan Antibody [NBP1-90300] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: beta Sarcoglycan Antibody [NBP1-90300] - Staining of human prostate shows very weak membranous positivity in smooth muscle cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: beta Sarcoglycan Antibody [NBP1-90300] - Staining of human skeletal muscle shows moderate membranous positivity in myocytes.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: beta Sarcoglycan Antibody [NBP1-90300] - Staining in human heart muscle and pancreas tissues using NBP1-90300 antibody. Corresponding SGCB RNA-seq data are presented for the same tissues.
