BS8031

antibody from Bioworld Technology, Inc

Targeting: RUNX1T1 AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8031

Provider

Bioworld Technology, Inc

Product name

RUNX1T1 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human RUNX1T1.

Description

ETO and ETO-2, which are alternatively designated MTG8 and MTG16, respectively, are members of the ETO transcription factor family . These transcription factors are characterized by a zinc-finger domain and four conserved domains, of which domain II is required for dimerization between family members . ETO and ETO-2 may function to mediate interactions between DNA binding proteins and transcriptional regulators, such as N-CoR. Frequently, the t(8;21) translocation of ETO produces the AML-1/ETO oncoprotein, which consists of the first 177 amino acids of AML-1 and all but the first 30 amino acids of ETO. AML-1/ETO expression is observed in 12ÿ15% of acute myelogenous, M2 subtype leukemias . The AML-1/ETO fusion proteins associate with multimeric N-CoR/mSin3/HDAC1 complexes, block differentiation and induce transcriptional repression by altering chromatin remodeling .

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.