AMM04050G

antibody from Leading Biology

Targeting: RUNX1T1 AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

AMM04050G

Provider

Leading Biology

Product name

RUNX1T1 Antibody (monoclonal) (M01)

Antibody type

Monoclonal

Description

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

5A12

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.