BS7921

antibody from Bioworld Technology, Inc

Targeting: SCNN1G ENaCgamma, SCNEG

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS7921

Provider

Bioworld Technology, Inc

Product name

SCNN1G polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human SCNN1G.

Description

The epithelial sodium channel (ENaC) is a member of the ENaC/DEG superfamily that is located on the apical surface of cells. ENaC mediates sodium reabsorption in kidney, distal colon, lung, ducts of exocrine glands and other organs. ENaC is formed by heteromultimerization of four homologous subunits, Ï«, ÉÇ, ÎÛ and Ñ´. The most frequently formed heterotetramer consists of two Ï«, one ÉÇ, and one ÎÛ subunit, but the Ï« subunit can be replaced by a ? subunit. The Ï«ENaC gene maps to human chromosome 12p13, and expresses a glycosylated protein. Both the ÉÇ and ÎÛENaC genes map to human chromosome 16p12, and the ÎÛENaC transcript is detected as a glycosylated protein. The carboxy-terminus of all ENaC subunits contains PY motifs, which interact with the ubiquitin protein ligase, Nedd4, to regulate intracellular sodium concentrations. Gain-of-function mutations involving the PY motif cause Liddle£ªs syndrome, an autosomal dominant form of hypertension, resulting from excessive renal sodium absorption. Conversely, ENaC loss-of-function mutations result in pseudohypoaldosteronism type I, a disorder characterized by salt wasting and hypotension.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.