Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [3]
- ELISA [1]
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- Product number
- ABIN393730 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Component of Oligomeric Golgi Complex 7 (COG7) (AA 1-771) antibody
- Antibody type
- Monoclonal
- Description
- This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Mouse
- Epitope
- AA 1-771
- Isotype
- IgG
- Antibody clone number
- 3G4-1B3
- Vial size
- 100 μg
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Submitted references A new mutation in COG7 extends the spectrum of COG subunit deficiencies.
Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing.
A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia.
COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins.
COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.
Zeevaert R, Foulquier F, Cheillan D, Cloix I, Guffon N, Sturiale L, Garozzo D, Matthijs G, Jaeken J
European journal of medical genetics 2009 Sep-Oct;52(5):303-5
European journal of medical genetics 2009 Sep-Oct;52(5):303-5
Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing.
Laufman O, Kedan A, Hong W, Lev S
The EMBO journal 2009 Jul 22;28(14):2006-17
The EMBO journal 2009 Jul 22;28(14):2006-17
A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia.
Morava E, Zeevaert R, Korsch E, Huijben K, Wopereis S, Matthijs G, Keymolen K, Lefeber DJ, De Meirleir L, Wevers RA
European journal of human genetics : EJHG 2007 Jun;15(6):638-45
European journal of human genetics : EJHG 2007 Jun;15(6):638-45
COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins.
Steet R, Kornfeld S
Molecular biology of the cell 2006 May;17(5):2312-21
Molecular biology of the cell 2006 May;17(5):2312-21
COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.
Shestakova A, Zolov S, Lupashin V
Traffic (Copenhagen, Denmark) 2006 Feb;7(2):191-204
Traffic (Copenhagen, Denmark) 2006 Feb;7(2):191-204
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Supportive validation
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- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
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- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- ELISA