Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 15397-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15397-1-AP, RRID:AB_2186234
- Product name
- SEC13 antibody
- Antibody type
- Polyclonal
- Description
- SEC13 antibody (Cat. #15397-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells.
Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length.
Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport.
The Sar1 GTPase is dispensable for COPII-dependent cargo export from the ER.
Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis.
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Selenoprotein K enhances STING oligomerization to facilitate antiviral response.
Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival.
Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.
DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity.
Structure of the nutrient-sensing hub GATOR2.
GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.
Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation.
Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum.
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.
Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons.
Dai W, Liu Z, Yan M, Nian X, Hong F, Zhou Z, Wang C, Fu X, Li X, Jiang M, Zhu Y, Huang Q, Lu X, Hou L, Yan N, Wang Q, Hu J, Mo W, Zhang X, Zhang L
Developmental cell 2024 Feb 26;59(4):482-495.e6
Developmental cell 2024 Feb 26;59(4):482-495.e6
Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length.
Kliszczak M, Moralli D, Jankowska JD, Bryjka P, Subha Meem L, Goncalves T, Hester SS, Fischer R, Clynes D, Green CM
Frontiers in cell and developmental biology 2023;11:1175069
Frontiers in cell and developmental biology 2023;11:1175069
Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport.
Kim N, Kim TH, Kim C, Lee JE, Kang MG, Shin S, Jung M, Kim JS, Mun JY, Rhee HW, Park SY, Shin Y, Yoo JY
Developmental cell 2023 Oct 9;58(19):1950-1966.e8
Developmental cell 2023 Oct 9;58(19):1950-1966.e8
The Sar1 GTPase is dispensable for COPII-dependent cargo export from the ER.
Kasberg W, Luong P, Hanna MG, Minushkin K, Tsao A, Shankar R, Block S, Audhya A
Cell reports 2023 Jun 27;42(6):112635
Cell reports 2023 Jun 27;42(6):112635
Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis.
Wu M, Li M, Liu W, Yan M, Li L, Ding W, Nian X, Dai W, Sun D, Zhu Y, Huang Q, Lu X, Cai Z, Hong F, Li X, Zhang L, Liu Z, Mo W, Zhang X, Zhang L
Cell reports 2023 Jul 25;42(7):112802
Cell reports 2023 Jul 25;42(7):112802
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Jiang C, Dai X, He S, Zhou H, Fang L, Guo J, Liu S, Zhang T, Pan W, Yu H, Fu T, Li D, Inuzuka H, Wang P, Xiao J, Wei W
Molecular cell 2023 Jan 5;83(1):74-89.e9
Molecular cell 2023 Jan 5;83(1):74-89.e9
Selenoprotein K enhances STING oligomerization to facilitate antiviral response.
Lv L, Chai L, Wang J, Wang M, Qin D, Song H, Fu Y, Zhao C, Jia J, Zhao W, Jia M
PLoS pathogens 2023 Apr;19(4):e1011314
PLoS pathogens 2023 Apr;19(4):e1011314
Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival.
Danan CH, Naughton KE, Hayer KE, Vellappan S, McMillan EA, Zhou Y, Matsuda R, Nettleford SK, Katada K, Parham LR, Ma X, Chowdhury A, Wilkins BJ, Shah P, Weitzman MD, Hamilton KE
bioRxiv : the preprint server for biology 2023 Apr 21;
bioRxiv : the preprint server for biology 2023 Apr 21;
Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.
You M, Wu F, Gao M, Chen M, Zeng S, Zhang Y, Zhao W, Li D, Wei L, Ruan XZ, Chen Y
Redox biology 2022 Nov;57:102500
Redox biology 2022 Nov;57:102500
DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity.
Chen B, Xu F, Gao Y, Hu G, Zhu K, Lu H, Xu A, Chen S, Wu L, Zhao G
Oncogene 2022 Mar;41(13):1918-1930
Oncogene 2022 Mar;41(13):1918-1930
Structure of the nutrient-sensing hub GATOR2.
Valenstein ML, Rogala KB, Lalgudi PV, Brignole EJ, Gu X, Saxton RA, Chantranupong L, Kolibius J, Quast JP, Sabatini DM
Nature 2022 Jul;607(7919):610-616
Nature 2022 Jul;607(7919):610-616
GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.
Morales J, Allegakoen DV, Garcia JA, Kwong K, Sahu PK, Fajardo DA, Pan Y, Horlbeck MA, Weissman JS, Gustafson WC, Bivona TG, Sabnis AJ
JCI insight 2022 Dec 8;7(23)
JCI insight 2022 Dec 8;7(23)
Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation.
Chen X, Yu C, Liu X, Liu B, Wu X, Wu J, Yan D, Han L, Tang Z, Yuan X, Wang J, Wang Y, Liu S, Shan L, Shang Y
Nature communications 2022 Dec 8;13(1):7578
Nature communications 2022 Dec 8;13(1):7578
Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum.
Niu L, Ma T, Yang F, Yan B, Tang X, Yin H, Wu Q, Huang Y, Yao ZP, Wang J, Guo Y, Hu J
Proceedings of the National Academy of Sciences of the United States of America 2019 Jul 9;116(28):14029-14038
Proceedings of the National Academy of Sciences of the United States of America 2019 Jul 9;116(28):14029-14038
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Kane M, Rebensburg SV, Takata MA, Zang TM, Yamashita M, Kvaratskhelia M, Bieniasz PD
eLife 2018 Aug 7;7
eLife 2018 Aug 7;7
TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.
Hanna MG 4th, Block S, Frankel EB, Hou F, Johnson A, Yuan L, Knight G, Moresco JJ, Yates JR 3rd, Ashton R, Schekman R, Tong Y, Audhya A
Proceedings of the National Academy of Sciences of the United States of America 2017 Sep 12;114(37):E7707-E7716
Proceedings of the National Academy of Sciences of the United States of America 2017 Sep 12;114(37):E7707-E7716
Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons.
Teodorof C, Divakar S, Soontornniyomkij B, Achim CL, Kaul M, Singh KK
Neurobiology of disease 2014 Sep;69:54-64
Neurobiology of disease 2014 Sep;69:54-64
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 15397-1-AP(SEC13 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using 15397-1-AP and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 15397-1-AP(SEC13 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 15397-1-AP(SEC13 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue