ABIN350044

antibody from antibodies-online

Targeting: TRPC4AP C20orf188, dJ756N5.2, DKFZp586C1223, DKFZP727M231, PPP1R158, TRRP4AP

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN350044

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN350044, RRID:AB_10782158

Product name

anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (Extracellular Domain) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide from the extracellular domain of human amiloride sensitive cation channel 2, neuronal (ACCN2, ASIC1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and shares 95% identity with mo

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

Extracellular Domain

Vial size

100 μL

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.

Handling

Avoid freeze and thaw cycles.

References

Submitted references

The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1.

Coric T, Zhang P, Todorovic N, Canessa CM
The Journal of biological chemistry 2003 Nov 14;278(46):45240-7

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Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).

Babini E, Paukert M, Geisler HS, Grunder S
The Journal of biological chemistry 2002 Nov 1;277(44):41597-603

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Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b.

Bässler EL, Ngo-Anh TJ, Geisler HS, Ruppersberg JP, Gründer S
The Journal of biological chemistry 2001 Sep 7;276(36):33782-7

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Cloning and functional expression of ASIC-beta2, a splice variant of ASIC-beta.

Ugawa S, Ueda T, Takahashi E, Hirabayashi Y, Yoneda T, Komai S, Shimada S
Neuroreport 2001 Sep 17;12(13):2865-9

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Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.

Voilley N, de Weille J, Mamet J, Lazdunski M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Oct 15;21(20):8026-33

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Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.

Escoubas P, De Weille JR, Lecoq A, Diochot S, Waldmann R, Champigny G, Moinier D, Ménez A, Lazdunski M
The Journal of biological chemistry 2000 Aug 18;275(33):25116-21

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Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.

Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ
Neuron 2000 Apr;26(1):133-41

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A sensory neuron-specific, proton-gated ion channel.

Chen CC, England S, Akopian AN, Wood JN
Proceedings of the National Academy of Sciences of the United States of America 1998 Aug 18;95(17):10240-5

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The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.

Bassilana F, Champigny G, Waldmann R, de Weille JR, Heurteaux C, Lazdunski M
The Journal of biological chemistry 1997 Nov 14;272(46):28819-22

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A proton-gated cation channel involved in acid-sensing.

Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M
Nature 1997 Mar 13;386(6621):173-7