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- Antigen structure
- References [14]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 16024-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16024-1-AP, RRID:AB_2136505
- Product name
- LETM1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LETM1 antibody (Cat. #16024-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma.
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction.
Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.
Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8.
A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance.
Minor contribution of NCX to Na(+)-Ca(2+) exchange activity in brain mitochondria.
HOXB7 acts as an oncogenic biomarker in head and neck squamous cell carcinoma.
Total Matrix Ca(2+) Modulates Ca(2+) Efflux via the Ca(2+)/H(+) Exchanger in Cardiac Mitochondria.
Evaluation of cancer-derived myocardial impairments using a mouse model.
Intake of medium-chain fatty acids induces myocardial oxidative stress and atrophy.
The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability.
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
Shi Y, Kang Q, Zhou H, Yue X, Bi Y, Luo Q
Genes & diseases 2024 May;11(3):100988
Genes & diseases 2024 May;11(3):100988
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S
Nature communications 2023 Oct 10;14(1):6344
Nature communications 2023 Oct 10;14(1):6344
Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction.
Chaanine AH, Higgins L, Lauterboeck L, Markowski T, Yang Q, Delafontaine P
Cells 2022 May 6;11(9)
Cells 2022 May 6;11(9)
Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.
Chern T, Achilleos A, Tong X, Hill MC, Saltzman AB, Reineke LC, Chaudhury A, Dasgupta SK, Redhead Y, Watkins D, Neilson JR, Thiagarajan P, Green JBA, Malovannaya A, Martin JF, Rosenblatt DS, Poché RA
Nature communications 2022 Jan 10;13(1):134
Nature communications 2022 Jan 10;13(1):134
Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8.
Hojo Y, Kishi S, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Nishiguchi Y, Nakashima C, Luo Y, Shinohara H, Kuniyasu H
International journal of molecular sciences 2022 Apr 4;23(7)
International journal of molecular sciences 2022 Apr 4;23(7)
A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance.
Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A
Science advances 2021 Sep 24;7(39):eabi7514
Science advances 2021 Sep 24;7(39):eabi7514
Minor contribution of NCX to Na(+)-Ca(2+) exchange activity in brain mitochondria.
Takeuchi A, Matsuoka S
Cell calcium 2021 Jun;96:102386
Cell calcium 2021 Jun;96:102386
HOXB7 acts as an oncogenic biomarker in head and neck squamous cell carcinoma.
Wu X, Li J, Yan T, Ke X, Li X, Zhu Y, Yang J, Li Z
Cancer cell international 2021 Jul 24;21(1):393
Cancer cell international 2021 Jul 24;21(1):393
Total Matrix Ca(2+) Modulates Ca(2+) Efflux via the Ca(2+)/H(+) Exchanger in Cardiac Mitochondria.
Natarajan GK, Glait L, Mishra J, Stowe DF, Camara AKS, Kwok WM
Frontiers in physiology 2020;11:510600
Frontiers in physiology 2020;11:510600
Evaluation of cancer-derived myocardial impairments using a mouse model.
Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Oncotarget 2020 Oct 13;11(41):3712-3722
Oncotarget 2020 Oct 13;11(41):3712-3722
Intake of medium-chain fatty acids induces myocardial oxidative stress and atrophy.
Miyagawa Y, Mori T, Goto K, Kawahara I, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kuniyasu H
Lipids in health and disease 2018 Nov 17;17(1):258
Lipids in health and disease 2018 Nov 17;17(1):258
The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability.
Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, Elrod JW
Nature 2017 May 4;545(7652):93-97
Nature 2017 May 4;545(7652):93-97
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.
Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ, Cheung JY, Madesh M, Elrod JW
Cell reports 2015 Jul 7;12(1):23-34
Cell reports 2015 Jul 7;12(1):23-34
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
Jiang D, Zhao L, Clish CB, Clapham DE
Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 11;110(24):E2249-54
Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 11;110(24):E2249-54
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 16024-1-AP(LETM1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using LETM1 antibody 16024-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 16024-1-AP(LETM1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 16024-1-AP(LETM1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
