BS8556

antibody from Bioworld Technology, Inc

Targeting: ATP2B2 PMCA2

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8556

Provider

Bioworld Technology, Inc

Product name

ATP2B2 polyclonal antibody

Antibody type

Polyclonal

Antigen

Plasma membrane calcium-transporting ATPase 2; PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2; PMCA2

Description

Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from four distinct genes, PMCA1, 2, 3, and 4. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. The human PMCA2 gene is located on chromosome 3, and antibodies directed against PMCA2 detect three proteins in brain and heart. Homozygous null mutations in the mouse gene result in deafwaddler mice, which are characterized by having a hesitant, wobbly gait, displaying head bobbing, and are deaf.

Reactivity

Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.