BS7646

antibody from Bioworld Technology, Inc
Targeting: RAG2
Provider product page for BS7646
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7646 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RAG2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human RAG2.
Description
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RAG2 protein structure - BS7646 shown in red.