10-1044

TMBIM6 antibody from ABEOMICS Inc.
BAXI1, BI-1, TEGT

Antibody data

Product number
10-1044
Provider
ABEOMICS Inc.
Product name
Anti-Bi-1 Antibody
Provider product page
ABEOMICS Inc. - 10-1044
Antibody type
Monoclonal
Description
Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased; however, up-regulated expression of this protein has been linked to increased cell proliferations.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant protei
n of human Bi-1 (amino acids 1-200)
was used as an immunogen for this
antibody.
Isotype
IgG
Antibody clone number
ABM20E4
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
Provider Type Product Number
- No reagents -