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- Antibody Data
- Antigen structure
- References [25]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 15240-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15240-1-AP, RRID:AB_1557426
- Product name
- HLA class I ABC antibody
- Antibody type
- Polyclonal
- Description
- HLA class I ABC antibody (Cat. #15240-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sequential modulation of the Wnt/β-catenin signaling pathway enhances tumor-intrinsic MHC I expression and tumor clearance.
Peripheral Injection of Tim-3 Antibody Attenuates VSV Encephalitis by Enhancing MHC-I Presentation.
Immune infiltration profiling in gastric cancer and their clinical implications.
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression.
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.
MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer.
Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity.
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.
Long Non-coding RNA LINC02195 as a Regulator of MHC I Molecules and Favorable Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
Noncoding RNA 886 alleviates tumor cellular immunological rejection in host C57BL/C mice.
Pancreatic beta cells persistently infected with coxsackievirus B4 are targets of NK cell-mediated cytolytic activity.
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress.
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
Activation of Toll-like receptor 7 signaling in labial salivary glands of primary Sjögren's syndrome patients.
Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis.
Loss of Fas expression and high expression of HLA-E promoting the immune escape of early colorectal cancer cells.
HIV-1 Nef: Taking Control of Protein Trafficking.
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer.
The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in salivary gland cancer. A clinicopathological study of 288 cases.
Dholakia J, Scalise CB, Katre AA, Goldsberry WN, Meza-Perez S, Randall TD, Norian LA, Novak L, Arend RC
Gynecologic oncology 2022 Jan;164(1):170-180
Gynecologic oncology 2022 Jan;164(1):170-180
Peripheral Injection of Tim-3 Antibody Attenuates VSV Encephalitis by Enhancing MHC-I Presentation.
Li G, Tang L, Hou C, Wang Z, Gao Y, Dou S, Mo R, Hao Y, Gao Z, Li Y, Dong J, Zhang J, Shen B, Wang R, Han G
Frontiers in immunology 2021;12:667478
Frontiers in immunology 2021;12:667478
Immune infiltration profiling in gastric cancer and their clinical implications.
Ren F, Zhao Q, Zhao M, Zhu S, Liu B, Bukhari I, Zhang K, Wu W, Fu Y, Yu Y, Tang Y, Zheng P, Mi Y
Cancer science 2021 Sep;112(9):3569-3584
Cancer science 2021 Sep;112(9):3569-3584
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Xu T, Dai J, Tang L, Yang L, Si L, Sheng X, Cui C, Chi Z, Kong Y, Guo J
The Journal of investigative dermatology 2021 Sep 25;
The Journal of investigative dermatology 2021 Sep 25;
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP
Cell 2021 Sep 2;184(18):4753-4771.e27
Cell 2021 Sep 2;184(18):4753-4771.e27
Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression.
Ren H, He G, Lu Z, He Q, Li S, Huang Z, Chen Z, Cao C, Wang A
Cancer science 2021 Jun;112(6):2173-2184
Cancer science 2021 Jun;112(6):2173-2184
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Liu W, Wang Y, Xie Y, Dai T, Fan M, Li C, Zou Y
Cell death discovery 2021 Jun 5;7(1):136
Cell death discovery 2021 Jun 5;7(1):136
Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.
Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 1;118(22)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 1;118(22)
MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer.
Wu SY, Xiao Y, Wei JL, Xu XE, Jin X, Hu X, Li DQ, Jiang YZ, Shao ZM
Journal for immunotherapy of cancer 2021 Jul;9(7)
Journal for immunotherapy of cancer 2021 Jul;9(7)
Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity.
Li C, Yao H, Wang H, Fang JY, Xu J
Oncogene 2021 Feb;40(6):1128-1146
Oncogene 2021 Feb;40(6):1128-1146
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.
Li C, Chi H, Deng S, Wang H, Yao H, Wang Y, Chen D, Guo X, Fang JY, He F, Xu J
Journal for immunotherapy of cancer 2021 Aug;9(8)
Journal for immunotherapy of cancer 2021 Aug;9(8)
Long Non-coding RNA LINC02195 as a Regulator of MHC I Molecules and Favorable Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Li H, Xiong HG, Xiao Y, Yang QC, Yang SC, Tang HC, Zhang WF, Sun ZJ
Frontiers in oncology 2020;10:615
Frontiers in oncology 2020;10:615
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
Zhang M, Fu M, Li M, Hu H, Gong S, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292
Noncoding RNA 886 alleviates tumor cellular immunological rejection in host C57BL/C mice.
Ma H, Wang M, Zhou Y, Yang JJ, Wang LY, Yang RH, Wen MJ, Kong L
Cancer medicine 2020 Jul;9(14):5258-5271
Cancer medicine 2020 Jul;9(14):5258-5271
Pancreatic beta cells persistently infected with coxsackievirus B4 are targets of NK cell-mediated cytolytic activity.
Nekoua MP, Bertin A, Sane F, Alidjinou EK, Lobert D, Trauet J, Hober C, Engelmann I, Moutairou K, Yessoufou A, Hober D
Cellular and molecular life sciences : CMLS 2020 Jan;77(1):179-194
Cellular and molecular life sciences : CMLS 2020 Jan;77(1):179-194
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, Xie L, Huang Q, Li F, Li CY
Nature 2020 Dec;588(7839):693-698
Nature 2020 Dec;588(7839):693-698
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress.
Merriman C, Fu D
The Journal of biological chemistry 2019 Nov 8;294(45):16992-17006
The Journal of biological chemistry 2019 Nov 8;294(45):16992-17006
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
Clancy JW, Zhang Y, Sheehan C, D'Souza-Schorey C
Nature cell biology 2019 Jul;21(7):856-866
Nature cell biology 2019 Jul;21(7):856-866
Activation of Toll-like receptor 7 signaling in labial salivary glands of primary Sjögren's syndrome patients.
Shimizu T, Nakamura H, Takatani A, Umeda M, Horai Y, Kurushima S, Michitsuji T, Nakashima Y, Kawakami A
Clinical and experimental immunology 2019 Apr;196(1):39-51
Clinical and experimental immunology 2019 Apr;196(1):39-51
Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis.
Guo Y, Zhang Z, Wei H, Wang J, Lv J, Zhang K, Keller ET, Yao Z, Wang Q
The Journal of pathology 2017 Oct;243(2):208-219
The Journal of pathology 2017 Oct;243(2):208-219
Loss of Fas expression and high expression of HLA-E promoting the immune escape of early colorectal cancer cells.
Huang R, Zhang D, Li F, Xiao Z, Wu M, Shi D, Xiang P, Bao Z
Oncology letters 2017 May;13(5):3379-3386
Oncology letters 2017 May;13(5):3379-3386
HIV-1 Nef: Taking Control of Protein Trafficking.
Pereira EA, daSilva LL
Traffic (Copenhagen, Denmark) 2016 Sep;17(9):976-96
Traffic (Copenhagen, Denmark) 2016 Sep;17(9):976-96
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
de Carvalho JV, de Castro RO, da Silva EZ, Silveira PP, da Silva-Januário ME, Arruda E, Jamur MC, Oliver C, Aguiar RS, daSilva LL
PloS one 2014;9(11):e113691
PloS one 2014;9(11):e113691
Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer.
Dobbin ZC, Katre AA, Steg AD, Erickson BK, Shah MM, Alvarez RD, Conner MG, Schneider D, Chen D, Landen CN
Oncotarget 2014 Sep 30;5(18):8750-64
Oncotarget 2014 Sep 30;5(18):8750-64
The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in salivary gland cancer. A clinicopathological study of 288 cases.
Müller M, Agaimy A, Zenk J, Ettl T, Iro H, Hartmann A, Seliger B, Schwarz S
Histopathology 2013 May;62(6):847-59
Histopathology 2013 May;62(6):847-59
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 15240-1-AP(HLA class I (HLA-A) antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 15240-1-AP( HLA class I (HLA-A) Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HLA class I (HLA-A) (IP:15240-1-AP, 3ug; Detection:15240-1-AP 1:500) with HepG2 cells lysate 1720ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human stomach cancer using 15240-1-AP(HLA class I (HLA-A) antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human stomach cancer using 15240-1-AP(HLA class I (HLA-A) antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HLA class I (HLA-A) antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HLA class I (HLA-A). This antibody recognizes human antigen. The HLA class I (HLA-A) antibody has been validated for the following applications: ELISA, WB, IHC, IF, IP, FC analysis.
