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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Flow cytometry [1]
- Other assay [4]
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- Product number
- 17-9876-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- HLA-A2 Monoclonal Antibody (BB7.2), APC, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This BB7.2 monoclonal antibody recognizes the human major histocompatibility complex (MHC) class I molecule HLA-A2, which is a member of the HLA-A family. MHC class I exists as a single alpha chain composed of three domains. This molecule associates with beta 2-microglobulin and is expressed on all nucleated cells.
- Antibody clone number
- BB7.2
- Concentration
- 5 µL/Test
Submitted references Single-cell transcriptome analysis of the heterogeneous effects of differential expression of tumor PD-L1 on responding TCR-T cells.
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.
Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4⁺ T Cells.
A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens.
Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.
A Novel Method Linking Antigen Presentation by Human Monocyte-Derived Macrophages to CD8(+) T Cell Polyfunctionality.
HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.
HIV-1 Nef disrupts antigen presentation early in the secretory pathway.
Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies.
Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28.
Ding R, Liu S, Wang S, Chen H, Wang F, Xu Q, Zhu L, Dong X, Gu Y, Zhang X, Chao CC, Gao Q
Theranostics 2021;11(10):4957-4974
Theranostics 2021;11(10):4957-4974
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.
Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, Kong X, Gerke C, Janssen L, Stickel E, Holst S, Plomp R, Mulder A, Ferrone S, Claas FHJ, Heemskerk MHM, Griffioen M, Halenius A, Overkleeft H, Huppa JB, Wuhrer M, Brummelkamp TR, Neefjes J, Spaapen RM
Immunity 2021 Jan 12;54(1):132-150.e9
Immunity 2021 Jan 12;54(1):132-150.e9
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.
Dawson NA, Lamarche C, Hoeppli RE, Bergqvist P, Fung VC, McIver E, Huang Q, Gillies J, Speck M, Orban PC, Bush JW, Mojibian M, Levings MK
JCI insight 2019 Mar 21;4(6)
JCI insight 2019 Mar 21;4(6)
Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4⁺ T Cells.
Tremblay-McLean A, Bruneau J, Lebouché B, Lisovsky I, Song R, Bernard NF
Viruses 2017 Oct 12;9(10)
Viruses 2017 Oct 12;9(10)
A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens.
Chang AY, Dao T, Gejman RS, Jarvis CA, Scott A, Dubrovsky L, Mathias MD, Korontsvit T, Zakhaleva V, Curcio M, Hendrickson RC, Liu C, Scheinberg DA
The Journal of clinical investigation 2017 Jun 30;127(7):2705-2718
The Journal of clinical investigation 2017 Jun 30;127(7):2705-2718
Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
Tomić A, Varanasi PR, Golemac M, Malić S, Riese P, Borst EM, Mischak-Weissinger E, Guzmán CA, Krmpotić A, Jonjić S, Messerle M
PLoS pathogens 2016 Dec;12(12):e1006015
PLoS pathogens 2016 Dec;12(12):e1006015
Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.
Tungatt K, Bianchi V, Crowther MD, Powell WE, Schauenburg AJ, Trimby A, Donia M, Miles JJ, Holland CJ, Cole DK, Godkin AJ, Peakman M, Straten PT, Svane IM, Sewell AK, Dolton G
Journal of immunology (Baltimore, Md. : 1950) 2015 Jan 1;194(1):463-74
Journal of immunology (Baltimore, Md. : 1950) 2015 Jan 1;194(1):463-74
A Novel Method Linking Antigen Presentation by Human Monocyte-Derived Macrophages to CD8(+) T Cell Polyfunctionality.
Short KR, Grant EJ, Vissers M, Reading PC, Diavatopoulos DA, Kedzierska K
Frontiers in immunology 2013;4:389
Frontiers in immunology 2013;4:389
HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.
Lubben NB, Sahlender DA, Motley AM, Lehner PJ, Benaroch P, Robinson MS
Molecular biology of the cell 2007 Sep;18(9):3351-65
Molecular biology of the cell 2007 Sep;18(9):3351-65
HIV-1 Nef disrupts antigen presentation early in the secretory pathway.
Kasper MR, Roeth JF, Williams M, Filzen TM, Fleis RI, Collins KL
The Journal of biological chemistry 2005 Apr 1;280(13):12840-8
The Journal of biological chemistry 2005 Apr 1;280(13):12840-8
Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies.
Brossart P, Heinrich KS, Stuhler G, Behnke L, Reichardt VL, Stevanovic S, Muhm A, Rammensee HG, Kanz L, Brugger W
Blood 1999 Jun 15;93(12):4309-17
Blood 1999 Jun 15;93(12):4309-17
Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28.
Parham P, Brodsky FM
Human immunology 1981 Dec;3(4):277-99
Human immunology 1981 Dec;3(4):277-99
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Mouse IgG2b K Isotype Control APC (Product # 17-4732-81) (blue histogram) or Anti-Human HLA-A2 APC (purple histogram). Cells in the lymphocyte gate were used for analysis.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
