SYT12

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

Description

Synaptotagmin 12

Tissue specificity

Group enriched (brain, liver, parathyroid gland)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (67006778 - 67050863)

Ensembl ID

ENSG00000173227  (ver. 103.38)

Orthologs

Mouse Syt12: ENSMUSG00000049303

UniProt

Q8IV01

neXtProt

NX_Q8IV01

Human splice variants
Mouse splice variants

Protein structure