APR03618G

antibody from Leading Biology

Targeting: NOD1 CARD4, CLR7.1, NLRC1

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

APR03618G

Provider

Leading Biology

Product name

NOD1 Antibody (C-term)

Antibody type

Polyclonal

Description

This gene encodes a member of the NOD (nucleotide-bindingoligomerization domain) family. This member is a cytosolic protein.It contains an N-terminal caspase recruitment domain (CARD), acentrally located nucleotide-binding domain (NBD), and 10 tandemleucine-rich repeats (LRRs) in its C terminus. The CARD is involvedin apoptotic signaling, LRRs participate in protein-proteininteractions, and mutations in the NBD may affect the process ofoligomerization and subsequent function of the LRR domain. Thisprotein is an intracellular pattern-recognition receptor (PRR) thatinitiates inflammation in response to a subset of bacteria throughthe detection of bacterial diaminopimelic acid. Multiplealternatively spliced transcript variants differring in the 5' UTRhave been described, but the full-length nature of these variantshas not been determined.

Reactivity

Human, Mouse

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.