Antibody data
- Antibody Data
- Antigen structure
- References [186]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11802-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11802-1-AP, RRID:AB_2207530
- Product name
- TOM20 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TOM20 antibody (Cat. #11802-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Bombyx mori cypovirus (BmCPV) induces PINK1-Parkin mediated mitophagy via interaction of VP4 with host Tom40.
Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
Melatonin Attenuates Chromium (VI)-Induced Spermatogonial Stem Cell/Progenitor Mitophagy by Restoration of METTL3-Mediated RNA N6-Methyladenosine Modification.
Receptor-Interacting Protein Kinase 3 Inhibition Prevents Cadmium-Mediated Macrophage Polarization and Subsequent Atherosclerosis via Maintaining Mitochondrial Homeostasis.
Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma via ROS/Mitochondria Pathway.
Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Systemic mitochondrial disruption is a key event in the toxicity of bacterial pore-forming toxins to Caenorhabditis elegans.
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.
Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency.
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells.
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival.
Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy.
TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis.
The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells.
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation.
Overexpression of HIF-1α enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis.
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Cilia locally synthesize proteins to sustain their ultrastructure and functions.
Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis.
Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1.
An in vitro system to silence mitochondrial gene expression.
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females†.
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.
Remote Ischemic Postconditioning Inhibited Mitophagy to Achieve Neuroprotective Effects in the Rat Model of Cardiac Arrest.
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans.
Machine learning-based classification of mitochondrial morphology in primary neurons and brain.
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties.
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons.
Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.
Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage.
FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy.
Apoptotic caspases suppress Mycobacterium bovis-induced IFN-β production in murine macrophage.
The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy.
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells.
Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.
Influence of Subcellular Localization and Functional State on Protein Turnover.
Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii.
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A1.
Active RNA interference in mitochondria.
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.
Lipidomics Reveals Dysregulated Glycerophospholipid Metabolism in the Corpus Striatum of Mice Treated with Cefepime.
Proteomic analysis of the exosomes secreted from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus reveals their involvement in the cellular responses to viral infection.
Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy.
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space.
Integrated lipidomic and transcriptomic analysis reveals clarithromycin-induced alteration of glycerophospholipid metabolism in the cerebral cortex of mice.
Facile Synthesis of Antibody-Coupled Polydopamine-Coated Magnetic Graphene Oxide Composites for Efficient Immunopurification and Metabolomics Analysis of Mitochondria.
The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro.
Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose tolerance through inhibition of NLRP3 inflammasome activation.
Monitoring mitochondrial translation in living cells.
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer.
Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway.
Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes.
Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission.
Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.
HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury.
Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.
Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice.
pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model.
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.
Methylene blue post-treatment improves hypoxia-ischemic recovery in a neonatal rat model.
Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space.
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Study of mitophagy and ATP-related metabolomics based on β-amyloid levels in Alzheimer's disease.
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.
FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses.
FSH prevents porcine granulosa cells from hypoxia-induced apoptosis via activating mitophagy through the HIF-1α-PINK1-Parkin pathway.
Hyperlipidemia Affects Tight Junctions and Pump Function in the Corneal Endothelium.
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis.
Quantitative Mitochondrial Proteomics Reveals ANXA7 as a Crucial Factor in Mitophagy.
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.
The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells.
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells.
Mitophagy in the Hippocampus Is Excessive Activated After Cardiac Arrest and Cardiopulmonary Resuscitation.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy.
Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin.
The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.
Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins.
SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.
Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.
Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy.
Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.
Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1α-dependent pathway.
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia.
Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation.
Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.
Mitochondria modulate programmed neuritic retraction.
ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells.
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Rapid affinity purification of intracellular organelles using a twin strep tag.
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack.
Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.
IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Parkin Modulates ERRα/eNOS Signaling Pathway in Endothelial Cells.
CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.
Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p.
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Generation and Characterization of SULT4A1 Mutant Mouse Models.
PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver.
Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions.
Photobiomodulation Therapy Attenuates Hypoxic-Ischemic Injury in a Neonatal Rat Model.
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.
Autophagy protects auditory hair cells against neomycin-induced damage.
Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats.
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.
A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis.
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.
Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.
Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Incorporation of VSV-G produces fusogenic plasma membrane vesicles capable of efficient transfer of bioactive macromolecules and mitochondria.
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).
PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.
Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development.
Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis.
Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy.
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization.
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin.
Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.
MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infection.
MicroRNA directly enhances mitochondrial translation during muscle differentiation.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism.
Mitochondrial abnormalities in temporal lobe of autistic brain.
UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria.
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
Zhu M, Pan J, Zhang M, Tong X, Zhang Y, Zhang Z, Liang Z, Zhang X, Hu X, Xue R, Cao G, Gong C
Developmental and comparative immunology 2022 Jan;126:104244
Developmental and comparative immunology 2022 Jan;126:104244
Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
Kang Y, Yin S, Liu J, Jiang Y, Huang Z, Chen L, Shao L
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
Melatonin Attenuates Chromium (VI)-Induced Spermatogonial Stem Cell/Progenitor Mitophagy by Restoration of METTL3-Mediated RNA N6-Methyladenosine Modification.
Lv Y, Li T, Yang M, Su L, Zhu Z, Zhao S, Zeng W, Zheng Y
Frontiers in cell and developmental biology 2021;9:684398
Frontiers in cell and developmental biology 2021;9:684398
Receptor-Interacting Protein Kinase 3 Inhibition Prevents Cadmium-Mediated Macrophage Polarization and Subsequent Atherosclerosis via Maintaining Mitochondrial Homeostasis.
Zhang J, Feng W, Li M, Chen P, Ning X, Ou C, Chen M
Frontiers in cardiovascular medicine 2021;8:737652
Frontiers in cardiovascular medicine 2021;8:737652
Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma via ROS/Mitochondria Pathway.
Ren Y, Lin Y, Chen J, Jin Y
Biological & pharmaceutical bulletin 2021;44(10):1557-1564
Biological & pharmaceutical bulletin 2021;44(10):1557-1564
Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.
Zhao R, Wang B, Wang D, Wu B, Ji P, Tan D
Oxidative medicine and cellular longevity 2021;2021:6675264
Oxidative medicine and cellular longevity 2021;2021:6675264
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Frontiers in immunology 2021;12:715098
Frontiers in immunology 2021;12:715098
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation.
Liu C, Wang L, Liu X, Tan Y, Tao L, Xiao Y, Deng P, Wang H, Deng Q, Lin Y, Jie H, Zhang H, Zhang J, Peng Y, Zhang H, Zhou Z, Sun Q, Cen X, Zhao Y
Theranostics 2021;11(6):2966-2986
Theranostics 2021;11(6):2966-2986
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring.
Yang L, Dong Y, Wu C, Youngblood H, Li Y, Zong X, Li L, Xu T, Zhang Q
Theranostics 2021;11(3):1269-1294
Theranostics 2021;11(3):1269-1294
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Systemic mitochondrial disruption is a key event in the toxicity of bacterial pore-forming toxins to Caenorhabditis elegans.
Shi J, Zhang F, Chen L, Bravo A, Soberón M, Sun M
Environmental microbiology 2021 Sep;23(9):4896-4907
Environmental microbiology 2021 Sep;23(9):4896-4907
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X
Nature communications 2021 Sep 6;12(1):5305
Nature communications 2021 Sep 6;12(1):5305
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.
Wang M, Wan C, He T, Han C, Zhu K, Waddington JL, Zhen X
Neuropharmacology 2021 Sep 15;196:108360
Neuropharmacology 2021 Sep 15;196:108360
Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency.
Ji C, Guo Y, Liu Y, Xu S, Zhao S, Luo X, Qiu F, Huang R, Xu Q, Zheng R, Xia M, Zhao Y, Ren J, Qiu Y
The ocular surface 2021 Oct;22:230-241
The ocular surface 2021 Oct;22:230-241
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells.
Kim ES, Jeon MT, Kim KS, Lee S, Kim S, Kim DG
Viruses 2021 Oct 8;13(10)
Viruses 2021 Oct 8;13(10)
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival.
Song Y, Ge X, Chen Y, Hussain T, Liang Z, Dong Y, Wang Y, Tang C, Zhou X
Autophagy 2021 Oct 31;:1-15
Autophagy 2021 Oct 31;:1-15
Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy.
Han X, Hu S, Yang Q, Sang X, Tang D, Cao G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct 30;:153835
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct 30;:153835
TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis.
Chen H, He A, Li H, Chen H, Xie H, Luo L, Huang Y, Chen J, Guan J, He Q, Ma J, Ou C, Tao A, Yan J
Cell death & disease 2021 Oct 13;12(10):938
Cell death & disease 2021 Oct 13;12(10):938
The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells.
Bhagawati M, Arroum T, Webeling N, Montoro AG, Mootz HD, Busch KB
Molecular biology of the cell 2021 Oct 1;32(20):br1
Molecular biology of the cell 2021 Oct 1;32(20):br1
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Xie QE, Wang MY, Cao ZP, Du X, Ji DM, Liang D, Cao YX, Liu YJ
Mitochondrion 2021 Nov;61:44-53
Mitochondrion 2021 Nov;61:44-53
Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation.
Song N, Fang Y, Zhu H, Liu J, Jiang S, Sun S, Xu R, Ding J, Hu G, Lu M
Redox biology 2021 Nov;47:102168
Redox biology 2021 Nov;47:102168
Overexpression of HIF-1α enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis.
Xu K, Lu C, Ren X, Wang J, Xu P, Zhang Y
Environmental toxicology 2021 Nov;36(11):2123-2137
Environmental toxicology 2021 Nov;36(11):2123-2137
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.
Tu C, Li H, Liu X, Wang Y, Li W, Meng L, Wang W, Li Y, Li D, Du J, Lu G, Lin G, Tan YQ
Autophagy 2021 Nov;17(11):3848-3864
Autophagy 2021 Nov;17(11):3848-3864
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C, Liu X, Yan C
Autophagy 2021 Nov;17(11):3592-3606
Autophagy 2021 Nov;17(11):3592-3606
Cilia locally synthesize proteins to sustain their ultrastructure and functions.
Hao K, Chen Y, Yan X, Zhu X
Nature communications 2021 Nov 30;12(1):6971
Nature communications 2021 Nov 30;12(1):6971
Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis.
Liu J, Wang X, Xue F, Zheng M, Luan Q
Journal of periodontal research 2021 Nov 26;
Journal of periodontal research 2021 Nov 26;
Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1.
Queliconi BB, Kojima W, Kimura M, Imai K, Udagawa C, Motono C, Hirokawa T, Tashiro S, Caaveiro JMM, Tsumoto K, Yamano K, Tanaka K, Matsuda N
Journal of cell science 2021 Nov 15;134(22)
Journal of cell science 2021 Nov 15;134(22)
An in vitro system to silence mitochondrial gene expression.
Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P
Cell 2021 Nov 11;184(23):5824-5837.e15
Cell 2021 Nov 11;184(23):5824-5837.e15
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.
Hirano T, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
Toxicology and applied pharmacology 2021 Nov 1;430:115723
Toxicology and applied pharmacology 2021 Nov 1;430:115723
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
Labbé K, Mookerjee S, Le Vasseur M, Gibbs E, Lerner C, Nunnari J
The Journal of cell biology 2021 Nov 1;220(11)
The Journal of cell biology 2021 Nov 1;220(11)
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Zhang Q, He X, Yao S, Lin T, Zhang L, Chen D, Chen C, Yang Q, Li F, Zhu YM, Guan MX
Nucleic acids research 2021 May 7;49(8):4689-4704
Nucleic acids research 2021 May 7;49(8):4689-4704
Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females†.
Zhang C, Tao L, Yue Y, Ren L, Zhang Z, Wang X, Tian J, An L
Biology of reproduction 2021 May 7;104(5):1114-1125
Biology of reproduction 2021 May 7;104(5):1114-1125
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.
Navinés-Ferrer A, Ainsua-Enrich E, Serrano-Candelas E, Proaño-Pérez E, Muñoz-Cano R, Gastaminza G, Olivera A, Martin M
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2277-2289
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2277-2289
Remote Ischemic Postconditioning Inhibited Mitophagy to Achieve Neuroprotective Effects in the Rat Model of Cardiac Arrest.
Huang Y, Gao X, Zhou X, Zhang Y, Tan Z, Zhu S
Neurochemical research 2021 Mar;46(3):573-583
Neurochemical research 2021 Mar;46(3):573-583
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY, Lin SC
Nature cell biology 2021 Mar;23(3):268-277
Nature cell biology 2021 Mar;23(3):268-277
A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans.
Li Y, Wang WL, Tu CF, Meng LL, Hu TY, Du J, Lin G, Nie HC, Tan YQ
Asian journal of andrology 2021 Mar-Apr;23(2):197-204
Asian journal of andrology 2021 Mar-Apr;23(2):197-204
Machine learning-based classification of mitochondrial morphology in primary neurons and brain.
Fogo GM, Anzell AR, Maheras KJ, Raghunayakula S, Wider JM, Emaus KJ, Bryson TD, Bukowski MJ, Neumar RW, Przyklenk K, Sanderson TH
Scientific reports 2021 Mar 4;11(1):5133
Scientific reports 2021 Mar 4;11(1):5133
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Li Y, Kang J, Fu J, Luo H, Liu Y, Li Y, Sun L
International journal of molecular sciences 2021 Mar 3;22(5)
International journal of molecular sciences 2021 Mar 3;22(5)
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties.
Huntington TE, Srinivasan R
Cell calcium 2021 Jun;96:102383
Cell calcium 2021 Jun;96:102383
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M
The Journal of cell biology 2021 Jun 7;220(6)
The Journal of cell biology 2021 Jun 7;220(6)
Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons.
Sutherland TC, Sefiani A, Horvat D, Huntington TE, Lei Y, West AP, Geoffroy CG
Cells 2021 Jun 29;10(7)
Cells 2021 Jun 29;10(7)
Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.
McGuirk S, Audet-Delage Y, Annis MG, Xue Y, Vernier M, Zhao K, St-Louis C, Minarrieta L, Patten DA, Morin G, Greenwood CM, Giguère V, Huang S, Siegel PM, St-Pierre J
eLife 2021 Jun 28;10
eLife 2021 Jun 28;10
Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage.
Yan XL, Xu FY, Ji JJ, Song P, Pei YQ, He MJ, Wang ZC, You SJ, Hua ZC, Cheng J, Jia J
Acta pharmacologica Sinica 2021 Jun 28;
Acta pharmacologica Sinica 2021 Jun 28;
FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
Zheng S, Jian D, Gan H, Wang L, Zhao J, Zhai X
Neuroscience letters 2021 Jun 21;756:135967
Neuroscience letters 2021 Jun 21;756:135967
Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.
Della-Flora Nunes G, Wilson ER, Marziali LN, Hurley E, Silvestri N, He B, O'Malley BW, Beirowski B, Poitelon Y, Wrabetz L, Feltri ML
Nature communications 2021 Jun 2;12(1):3285
Nature communications 2021 Jun 2;12(1):3285
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Human molecular genetics 2021 Jun 17;30(13):1230-1246
25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy.
Cao Q, Luo J, Xiong Y, Liu Z, Ye Q
International immunopharmacology 2021 Jul;96:107643
International immunopharmacology 2021 Jul;96:107643
Apoptotic caspases suppress Mycobacterium bovis-induced IFN-β production in murine macrophage.
Song Y, Dong Y, Liao Y, Liang Z, Yao J, Zhou X
The Journal of infection 2021 Jul;83(1):61-68
The Journal of infection 2021 Jul;83(1):61-68
The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy.
Liu D, Sun Z, Ye T, Li J, Zeng B, Zhao Q, Wang J, Xing HR
FEBS open bio 2021 Jul;11(7):1997-2007
FEBS open bio 2021 Jul;11(7):1997-2007
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
Wang F, Chen X, Cheng H, Song L, Liu J, Caplan S, Zhu L, Wu JY
EMBO reports 2021 Jul 5;22(7):e52006
EMBO reports 2021 Jul 5;22(7):e52006
Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells.
Haschler TN, Horsley H, Balys M, Anderson G, Taanman JW, Unwin RJ, Norman JT
Scientific reports 2021 Jul 30;11(1):15510
Scientific reports 2021 Jul 30;11(1):15510
Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.
Li A, Li X, Yi J, Ma J, Zhou J
International journal of molecular sciences 2021 Jul 10;22(14)
International journal of molecular sciences 2021 Jul 10;22(14)
Influence of Subcellular Localization and Functional State on Protein Turnover.
Yousefi R, Jevdokimenko K, Kluever V, Pacheu-Grau D, Fornasiero EF
Cells 2021 Jul 10;10(7)
Cells 2021 Jul 10;10(7)
Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii.
Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I, Tan MW
Scientific reports 2021 Jan 12;11(1):618
Scientific reports 2021 Jan 12;11(1):618
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A1.
Qin S, Ye L, Zheng Y, Gao J
FEBS letters 2021 Feb;595(4):507-520
FEBS letters 2021 Feb;595(4):507-520
Active RNA interference in mitochondria.
Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X
Cell research 2021 Feb;31(2):219-228
Cell research 2021 Feb;31(2):219-228
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H
Autophagy 2021 Feb;17(2):496-511
Autophagy 2021 Feb;17(2):496-511
Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.
Meng Q, Zaharieva EK, Sasatani M, Kobayashi J
Redox report : communications in free radical research 2021 Dec;26(1):160-169
Redox report : communications in free radical research 2021 Dec;26(1):160-169
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Liu W, Xu L, Wang X, Zhang D, Sun G, Wang M, Wang M, Han Y, Chai R, Wang H
Autophagy 2021 Dec;17(12):4159-4181
Autophagy 2021 Dec;17(12):4159-4181
Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.
Peng G, Zheng H, Wu C, Wu C, Ma X, Xiong J, Hou J, Zhang L, Yang L, Pan H
Brain research 2021 Dec 1;1772:147665
Brain research 2021 Dec 1;1772:147665
Lipidomics Reveals Dysregulated Glycerophospholipid Metabolism in the Corpus Striatum of Mice Treated with Cefepime.
Liu X, Wei Q, Yang X, Wang X, Zhang J, Xu R, Zhang H, Wang S, Wan X, Jiang L, He Y, Li S, Chen R, Wang Y, Chen Y, Qin F, Chen Y, Dai Y, Li H, Zhao Y, Zhang H, Bu Q, Wang H, Tian J, Zhao Y, Cen X
ACS chemical neuroscience 2021 Dec 1;12(23):4449-4464
ACS chemical neuroscience 2021 Dec 1;12(23):4449-4464
Proteomic analysis of the exosomes secreted from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus reveals their involvement in the cellular responses to viral infection.
Zhang X, Zhang Y, Pan J, Zhu M, Liang Z, Shen Z, Dai K, Yan B, Dai Y, Xue R, Cao G, Hu X, Gong C
Fish physiology and biochemistry 2021 Aug;47(4):857-867
Fish physiology and biochemistry 2021 Aug;47(4):857-867
Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy.
Han X, Xu T, Fang Q, Zhang H, Yue L, Hu G, Sun L
Redox biology 2021 Aug;44:102010
Redox biology 2021 Aug;44:102010
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Sun H, Ou T, Hu J, Yang Z, Lei Q, Li Y, Wang G, Li Y, Wu K, Wang S, Wu S
Biochemical pharmacology 2021 Aug;190:114588
Biochemical pharmacology 2021 Aug;190:114588
Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space.
Yao D, Li Y, Zeng S, Li Z, Shah Z, Song B, Liu J, Wu Y, Yang L, Long Q, Wang W, Hu Z, Tang H, Liu X
Science China. Life sciences 2021 Aug 31;
Science China. Life sciences 2021 Aug 31;
Integrated lipidomic and transcriptomic analysis reveals clarithromycin-induced alteration of glycerophospholipid metabolism in the cerebral cortex of mice.
Wang X, Wang L, Luo M, Bu Q, Liu C, Jiang L, Xu R, Wang S, Zhang H, Zhang J, Wan X, Li H, Wang Y, Liu B, Zhao Y, Chen Y, Dai Y, Li M, Wang H, Tian J, Zhao Y, Cen X
Cell biology and toxicology 2021 Aug 30;
Cell biology and toxicology 2021 Aug 30;
Facile Synthesis of Antibody-Coupled Polydopamine-Coated Magnetic Graphene Oxide Composites for Efficient Immunopurification and Metabolomics Analysis of Mitochondria.
Chang M, Wang Q, Liu X, Shi X, Xu G
Analytical chemistry 2021 Aug 17;93(32):11099-11107
Analytical chemistry 2021 Aug 17;93(32):11099-11107
The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro.
Haasler L, Kondadi AK, Tsigaras T, von Montfort C, Graf P, Stahl W, Brenneisen P
Archives of toxicology 2021 Apr;95(4):1349-1365
Archives of toxicology 2021 Apr;95(4):1349-1365
Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose tolerance through inhibition of NLRP3 inflammasome activation.
Zhang C, Li X, Hu X, Xu Q, Zhang Y, Liu H, Diao Y, Zhang X, Li L, Yu J, Yin H, Peng J
International immunopharmacology 2021 Apr;93:107412
International immunopharmacology 2021 Apr;93:107412
Monitoring mitochondrial translation in living cells.
Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D
EMBO reports 2021 Apr 7;22(4):e51635
EMBO reports 2021 Apr 7;22(4):e51635
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Shu L, Hu C, Xu M, Yu J, He H, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z
The EMBO journal 2021 Apr 15;40(8):e106283
The EMBO journal 2021 Apr 15;40(8):e106283
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer.
Cieśla M, Ngoc PCT, Cordero E, Martinez ÁS, Morsing M, Muthukumar S, Beneventi G, Madej M, Munita R, Jönsson T, Lövgren K, Ebbesson A, Nodin B, Hedenfalk I, Jirström K, Vallon-Christersson J, Honeth G, Staaf J, Incarnato D, Pietras K, Bosch A, Bellodi C
Molecular cell 2021 Apr 1;81(7):1453-1468.e12
Molecular cell 2021 Apr 1;81(7):1453-1468.e12
Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway.
Zhao F, Feng LX, Liu Q, Wang HS, Tang CY, Cheng W, Deng YH, Wu X, Yan P, Duan XJ, Peng JC, Duan SB
Oxidative medicine and cellular longevity 2020;2020:1898213
Oxidative medicine and cellular longevity 2020;2020:1898213
Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes.
Contino S, Suelves N, Vrancx C, Vadukul DM, Payen VL, Stanga S, Bertrand L, Kienlen-Campard P
Frontiers in neuroscience 2020;14:586108
Frontiers in neuroscience 2020;14:586108
Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission.
Song N, Zhu H, Xu R, Liu J, Fang Y, Zhang J, Ding J, Hu G, Lu M
Frontiers in pharmacology 2020;11:618992
Frontiers in pharmacology 2020;11:618992
Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.
Sakaguchi N, Sasai M, Bando H, Lee Y, Pradipta A, Ma JS, Yamamoto M
Frontiers in immunology 2020;11:561948
Frontiers in immunology 2020;11:561948
HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury.
Fu ZJ, Wang ZY, Xu L, Chen XH, Li XX, Liao WT, Ma HK, Jiang MD, Xu TT, Xu J, Shen Y, Song B, Gao PJ, Han WQ, Zhang W
Redox biology 2020 Sep;36:101671
Redox biology 2020 Sep;36:101671
Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.
Wang YY, Ke CC, Chen YL, Lin YH, Yu IS, Ku WC, O'Bryan MK, Lin YH
PLoS genetics 2020 Sep;16(9):e1009020
PLoS genetics 2020 Sep;16(9):e1009020
Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice.
He X, Liu C, Yang X, Lv M, Ni X, Li Q, Cheng H, Liu W, Tian S, Wu H, Gao Y, Yang C, Tan Q, Cong J, Tang D, Zhang J, Song B, Zhong Y, Li H, Zhi W, Mao X, Fu F, Ge L, Shen Q, Zhang M, Saiyin H, Jin L, Xu Y, Zhou P, Wei Z, Zhang F, Cao Y
American journal of human genetics 2020 Sep 3;107(3):514-526
American journal of human genetics 2020 Sep 3;107(3):514-526
pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model.
Xu X, Ng B, Sim B, Radulescu CI, Yusof NABM, Goh WI, Lin S, Lim JSY, Cha Y, Kusko R, Kay C, Ratovitski T, Ross C, Hayden MR, Wright G, Pouladi MA
Cell death & disease 2020 Sep 25;11(9):809
Cell death & disease 2020 Sep 25;11(9):809
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.
Liu X, Wang X, Li J, Hu S, Deng Y, Yin H, Bao X, Zhang QC, Wang G, Wang B, Shi Q, Shan G
Science China. Life sciences 2020 Oct;63(10):1429-1449
Science China. Life sciences 2020 Oct;63(10):1429-1449
Methylene blue post-treatment improves hypoxia-ischemic recovery in a neonatal rat model.
Zhang G, Lu Y, Yang L, Dong Y, Wen J, Xu J, Zhang Q
Neurochemistry international 2020 Oct;139:104782
Neurochemistry international 2020 Oct;139:104782
Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space.
Thevarajan I, Zolkiewski M, Zolkiewska A
The international journal of biochemistry & cell biology 2020 Oct;127:105841
The international journal of biochemistry & cell biology 2020 Oct;127:105841
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Hu C, Shu L, Huang X, Yu J, Li L, Gong L, Yang M, Wu Z, Gao Z, Zhao Y, Chen L, Song Z
Cell death & disease 2020 Oct 31;11(10):940
Cell death & disease 2020 Oct 31;11(10):940
Study of mitophagy and ATP-related metabolomics based on β-amyloid levels in Alzheimer's disease.
Xiong X, Li S, Han TL, Zhou F, Zhang X, Tian M, Tang L, Li Y
Experimental cell research 2020 Nov 1;396(1):112266
Experimental cell research 2020 Nov 1;396(1):112266
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.
Lee H, Smith SB, Sheu SS, Yoon Y
The Journal of biological chemistry 2020 May 8;295(19):6543-6560
The Journal of biological chemistry 2020 May 8;295(19):6543-6560
FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses.
Qi F, Meng Q, Hayashi I, Kobayashi J
Journal of radiation research 2020 May 22;61(3):368-375
Journal of radiation research 2020 May 22;61(3):368-375
FSH prevents porcine granulosa cells from hypoxia-induced apoptosis via activating mitophagy through the HIF-1α-PINK1-Parkin pathway.
Li C, Zhou J, Liu Z, Zhou J, Yao W, Tao J, Shen M, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3631-3645
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3631-3645
Hyperlipidemia Affects Tight Junctions and Pump Function in the Corneal Endothelium.
Bu J, Yu J, Wu Y, Cai X, Li K, Tang L, Jiang N, Jeyalatha MV, Zhang M, Sun H, He H, Quantock AJ, Chen Y, Liu Z, Li W
The American journal of pathology 2020 Mar;190(3):563-576
The American journal of pathology 2020 Mar;190(3):563-576
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Yan C, Gong L, Chen L, Xu M, Abou-Hamdan H, Tang M, Désaubry L, Song Z
Autophagy 2020 Mar;16(3):419-434
Autophagy 2020 Mar;16(3):419-434
Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis.
Cherubini M, Lopez-Molina L, Gines S
Neurobiology of disease 2020 Mar;136:104741
Neurobiology of disease 2020 Mar;136:104741
Quantitative Mitochondrial Proteomics Reveals ANXA7 as a Crucial Factor in Mitophagy.
Meng K, Lu S, Yan X, Sun Y, Gao J, Wang Y, Yin X, Sun Z, He QY
Journal of proteome research 2020 Mar 6;19(3):1275-1284
Journal of proteome research 2020 Mar 6;19(3):1275-1284
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
Tokuyama T, Hirai A, Shiiba I, Ito N, Matsuno K, Takeda K, Saito K, Mii K, Matsushita N, Fukuda T, Inatome R, Yanagi S
Biomolecules 2020 Mar 13;10(3)
Biomolecules 2020 Mar 13;10(3)
Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.
Zhang S, Reljić B, Liang C, Kerouanton B, Francisco JC, Peh JH, Mary C, Jagannathan NS, Olexiouk V, Tang C, Fidelito G, Nama S, Cheng RK, Wee CL, Wang LC, Duek Roggli P, Sampath P, Lane L, Petretto E, Sobota RM, Jesuthasan S, Tucker-Kellogg L, Reversade B, Menschaert G, Sun L, Stroud DA, Ho L
Nature communications 2020 Mar 11;11(1):1312
Nature communications 2020 Mar 11;11(1):1312
The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells.
Fazzari M, Audano M, Lunghi G, Di Biase E, Loberto N, Mauri L, Mitro N, Sonnino S, Chiricozzi E
Glycoconjugate journal 2020 Jun;37(3):293-306
Glycoconjugate journal 2020 Jun;37(3):293-306
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, Li L, Zhang L
Biochemical pharmacology 2020 Jul;177:113997
Biochemical pharmacology 2020 Jul;177:113997
Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells.
Zhang ZL, Wang NN, Ma QL, Chen Y, Yao L, Zhang L, Li QS, Shi MH, Wang HF, Ying Z
Acta pharmacologica Sinica 2020 Jan;41(1):93-100
Acta pharmacologica Sinica 2020 Jan;41(1):93-100
Mitophagy in the Hippocampus Is Excessive Activated After Cardiac Arrest and Cardiopulmonary Resuscitation.
Huang Y, Gao X, Zhou X, Xie B, Zhang Y, Zhu J, Zhu S
Neurochemical research 2020 Feb;45(2):322-330
Neurochemical research 2020 Feb;45(2):322-330
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AWM, Akkermans JJLL, Wijdeven RHM, Janssen GMC, van Veelen PA, Neefjes J
Cell reports 2020 Dec 8;33(10):108475
Cell reports 2020 Dec 8;33(10):108475
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR 3rd, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH Jr, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium., Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium., Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ
Science (New York, N.Y.) 2020 Dec 4;370(6521)
Science (New York, N.Y.) 2020 Dec 4;370(6521)
A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy.
Chen JL, Wang XX, Chen L, Tang J, Xia YF, Qian K, Qin ZH, Waeber C, Sheng R
Neuropharmacology 2020 Dec 15;181:108326
Neuropharmacology 2020 Dec 15;181:108326
Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin.
García-Puga M, Saenz-Antoñanzas A, Fernández-Torrón R, Munain AL, Matheu A
Aging 2020 Apr 8;12(7):6260-6275
Aging 2020 Apr 8;12(7):6260-6275
The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.
Pandey R, Bakay M, Hain HS, Strenkowski B, Yermakova A, Kushner JA, Orange JS, Hakonarson H
Frontiers in immunology 2019;10:68
Frontiers in immunology 2019;10:68
Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.
Liao Y, Hussain T, Liu C, Cui Y, Wang J, Yao J, Chen H, Song Y, Sabir N, Hussain M, Zhao D, Zhou X
Frontiers in immunology 2019;10:268
Frontiers in immunology 2019;10:268
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Liu T, Li X, Wu M, Qin L, Chen H, Qian P
Frontiers in microbiology 2019;10:1202
Frontiers in microbiology 2019;10:1202
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins.
Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL
Science China. Life sciences 2019 Sep;62(9):1117-1135
Science China. Life sciences 2019 Sep;62(9):1117-1135
SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.
Hossain MI, Marcus JM, Lee JH, Garcia PL, Gagné JP, Poirier GG, Falany CN, Andrabi SA
Drug metabolism and disposition: the biological fate of chemicals 2019 Sep;47(9):949-953
Drug metabolism and disposition: the biological fate of chemicals 2019 Sep;47(9):949-953
Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.
Wang W, Wang M, Ruan Y, Tan J, Wang H, Yang T, Li J, Zhou Q
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10097-10106
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10097-10106
Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy.
Doki T, Yamashita S, Wei FY, Hara K, Yamamoto T, Zhang Z, Zhang X, Tawara N, Hino H, Uyama E, Kurashige T, Maruyama H, Tomizawa K, Ando Y
Laboratory investigation; a journal of technical methods and pathology 2019 Nov;99(11):1728-1740
Laboratory investigation; a journal of technical methods and pathology 2019 Nov;99(11):1728-1740
Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.
Módis K, Ramanujam VS, Govar AA, Lopez E, Anderson KE, Wang R, Szabo C
Biochemical pharmacology 2019 Nov;169:113604
Biochemical pharmacology 2019 Nov;169:113604
Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1α-dependent pathway.
Saccà CD, Gorini F, Ambrosio S, Amente S, Faicchia D, Matarese G, Lania L, Majello B
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 May;1862(5):535-546
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 May;1862(5):535-546
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Wang P, Deng J, Dong J, Liu J, Bigio EH, Mesulam M, Wang T, Sun L, Wang L, Lee AY, McGee WA, Chen X, Fushimi K, Zhu L, Wu JY
PLoS genetics 2019 May;15(5):e1007947
PLoS genetics 2019 May;15(5):e1007947
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
Sabir N, Hussain T, Liao Y, Wang J, Song Y, Shahid M, Cheng G, Mangi MH, Yao J, Yang L, Zhao D, Zhou X
Cells 2019 May 5;8(5)
Cells 2019 May 5;8(5)
The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20.
Zhang C, Wang R, Liu Z, Bunker E, Lee S, Giuntini M, Chapnick D, Liu X
The Journal of biological chemistry 2019 May 3;294(18):7472-7487
The Journal of biological chemistry 2019 May 3;294(18):7472-7487
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5
Cell reports 2019 May 14;27(7):2075-2091.e5
Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions.
Wang R, Dong Y, Lu Y, Zhang W, Brann DW, Zhang Q
Molecular neurobiology 2019 Mar;56(3):1852-1869
Molecular neurobiology 2019 Mar;56(3):1852-1869
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia.
Yang L, Dong Y, Wu C, Li Y, Guo Y, Yang B, Zong X, Hamblin MR, Liu TC, Zhang Q
Journal of biophotonics 2019 Jun;12(6):e201800359
Journal of biophotonics 2019 Jun;12(6):e201800359
Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation.
Smith GA, Lin TH, Sheehan AE, Van der Goes van Naters W, Neukomm LJ, Graves HK, Bis-Brewer DM, Züchner S, Freeman MR
Neuron 2019 Jul 3;103(1):52-65.e6
Neuron 2019 Jul 3;103(1):52-65.e6
Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.
Li SZ, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W, Zhong B, Zhang XD
Nature communications 2019 Jul 19;10(1):3233
Nature communications 2019 Jul 19;10(1):3233
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, Luo O, Wang S, Wei J, Ding Y, Yu D
EBioMedicine 2019 Jan;39:239-254
EBioMedicine 2019 Jan;39:239-254
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G
Autophagy 2019 Jan;15(1):113-130
Autophagy 2019 Jan;15(1):113-130
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
Mitochondria modulate programmed neuritic retraction.
Baranov SV, Baranova OV, Yablonska S, Suofu Y, Vazquez AL, Kozai TDY, Cui XT, Ferrando LM, Larkin TM, Tyurina YY, Kagan VE, Carlisle DL, Kristal BS, Friedlander RM
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):650-659
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):650-659
ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P
The Journal of cell biology 2019 Feb 4;218(2):598-614
The Journal of cell biology 2019 Feb 4;218(2):598-614
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells.
Zhou Q, Li H, Li Y, Tan M, Fan S, Cao C, Meng F, Zhu L, Zhao L, Guan MX, Jin H, Sun Y
JCI insight 2019 Feb 21;4(4)
JCI insight 2019 Feb 21;4(4)
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N
eLife 2019 Dec 3;8
eLife 2019 Dec 3;8
Rapid affinity purification of intracellular organelles using a twin strep tag.
Xiong J, He J, Xie WP, Hinojosa E, Ambati CSR, Putluri N, Kim HE, Zhu MX, Du G
Journal of cell science 2019 Dec 13;132(24)
Journal of cell science 2019 Dec 13;132(24)
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S
Nature 2019 Aug;572(7771):614-619
Nature 2019 Aug;572(7771):614-619
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
Nagashima S, Takeda K, Ohno N, Ishido S, Aoki M, Saitoh Y, Takada T, Tokuyama T, Sugiura A, Fukuda T, Matsushita N, Inatome R, Yanagi S
Life science alliance 2019 Aug;2(4)
Life science alliance 2019 Aug;2(4)
Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack.
Martinez-Arroyo O, Gruevska A, Victor VM, González-Polo RA, Yakhine-Diop SMS, Fuentes JM, Esplugues JV, Blas-Garcia A, Apostolova N
Antiviral research 2019 Aug;168:36-50
Antiviral research 2019 Aug;168:36-50
Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.
Libiad M, Vitvitsky V, Bostelaar T, Bak DW, Lee HJ, Sakamoto N, Fearon E, Lyssiotis CA, Weerapana E, Banerjee R
The Journal of biological chemistry 2019 Aug 9;294(32):12077-12090
The Journal of biological chemistry 2019 Aug 9;294(32):12077-12090
IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.
Bartok A, Weaver D, Golenár T, Nichtova Z, Katona M, Bánsághi S, Alzayady KJ, Thomas VK, Ando H, Mikoshiba K, Joseph SK, Yule DI, Csordás G, Hajnóczky G
Nature communications 2019 Aug 19;10(1):3726
Nature communications 2019 Aug 19;10(1):3726
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
He Q, Li Z, Meng C, Wu J, Zhao Y, Zhao J
Cells 2019 Aug 14;8(8)
Cells 2019 Aug 14;8(8)
MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Takeda K, Nagashima S, Shiiba I, Uda A, Tokuyama T, Ito N, Fukuda T, Matsushita N, Ishido S, Iwawaki T, Uehara T, Inatome R, Yanagi S
The EMBO journal 2019 Aug 1;38(15):e100999
The EMBO journal 2019 Aug 1;38(15):e100999
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Parkin Modulates ERRα/eNOS Signaling Pathway in Endothelial Cells.
Xia W, Yin J, Zhang S, Guo C, Li Y, Zhang Y, Zhang A, Jia Z, Chen H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):2022-2034
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):2022-2034
CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.
Pandey R, Bakay M, Hain HS, Strenkowski B, Elsaqa BZB, Roizen JD, Kushner JA, Orange JS, Hakonarson H
PloS one 2018;13(9):e0203952
PloS one 2018;13(9):e0203952
Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p.
Zhang J, Liu L, Xue Y, Ma Y, Liu X, Li Z, Li Z, Liu Y
Frontiers in molecular neuroscience 2018;11:92
Frontiers in molecular neuroscience 2018;11:92
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
Gao X, Chen D, Hu X, Zhou Y, Wang Y, Wu C, Chen J, Wang Y, Pei R, Chen X
Journal of innate immunity 2018;10(4):315-327
Journal of innate immunity 2018;10(4):315-327
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC
Scientific reports 2018 Sep 18;8(1):14013
Scientific reports 2018 Sep 18;8(1):14013
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y, Guan MX
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Yu Z, Ma J, Li X, Liu Y, Li M, Wang L, Zhao M, He H, Zhang Y, Rao Q, Zhao D, Wang Y, Fan L, Li P, Liu Y, Liu F, Zhang F, Ye J, Yan Q, Guo S, Wang Z
Scientific reports 2018 Jul 2;8(1):9972
Scientific reports 2018 Jul 2;8(1):9972
Generation and Characterization of SULT4A1 Mutant Mouse Models.
Garcia PL, Hossain MI, Andrabi SA, Falany CN
Drug metabolism and disposition: the biological fate of chemicals 2018 Jan;46(1):41-45
Drug metabolism and disposition: the biological fate of chemicals 2018 Jan;46(1):41-45
PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver.
Xiao Y, Zhou Y, Lu Y, Zhou K, Cai W
Cell death & disease 2018 Feb 7;9(2):160
Cell death & disease 2018 Feb 7;9(2):160
Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions.
Song Y, Du Y, Zou W, Luo Y, Zhang X, Fu J
Scientific reports 2018 Feb 19;8(1):3301
Scientific reports 2018 Feb 19;8(1):3301
Photobiomodulation Therapy Attenuates Hypoxic-Ischemic Injury in a Neonatal Rat Model.
Tucker LD, Lu Y, Dong Y, Yang L, Li Y, Zhao N, Zhang Q
Journal of molecular neuroscience : MN 2018 Aug;65(4):514-526
Journal of molecular neuroscience : MN 2018 Aug;65(4):514-526
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cai WF, Zhang C, Wu YQ, Zhuang G, Ye Z, Zhang CS, Lin SC
Cell research 2018 Aug;28(8):865-867
Cell research 2018 Aug;28(8):865-867
Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.
Contino S, Porporato PE, Bird M, Marinangeli C, Opsomer R, Sonveaux P, Bontemps F, Dewachter I, Octave JN, Bertrand L, Stanga S, Kienlen-Campard P
Frontiers in physiology 2017;8:796
Frontiers in physiology 2017;8:796
Autophagy protects auditory hair cells against neomycin-induced damage.
He Z, Guo L, Shu Y, Fang Q, Zhou H, Liu Y, Liu D, Lu L, Zhang X, Ding X, Liu D, Tang M, Kong W, Sha S, Li H, Gao X, Chai R
Autophagy 2017;13(11):1884-1904
Autophagy 2017;13(11):1884-1904
Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats.
Zeng HL, Yang Q, Du H, Li H, Shen Y, Liu T, Chen X, Kamal GM, Guan Q, Cheng L, Wang J, Xu F
Oncotarget 2017 Nov 24;8(60):102020-102032
Oncotarget 2017 Nov 24;8(60):102020-102032
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
Liu G, Park SH, Imbesi M, Nathan WJ, Zou X, Zhu Y, Jiang H, Parisiadou L, Gius D
Antioxidants & redox signaling 2017 May 20;26(15):849-863
Antioxidants & redox signaling 2017 May 20;26(15):849-863
Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.
Sun S, Liu J, Zhao M, Han Y, Chen P, Mo Q, Wang B, Chen G, Fang Y, Tian Y, Zhou J, Ma D, Gao Q, Wu P
Cell death & disease 2017 Jun 8;8(6):e2870
Cell death & disease 2017 Jun 8;8(6):e2870
A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis.
Zhang J, Liu X, Liang X, Lu Y, Zhu L, Fu R, Ji Y, Fan W, Chen J, Lin B, Yuan Y, Jiang P, Zhou X, Guan MX
Scientific reports 2017 Jul 18;7(1):5704
Scientific reports 2017 Jul 18;7(1):5704
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed ME, Zhu L, Liu TC, Cohen RM, Zhang Q
Neurobiology of aging 2017 Jan;49:165-182
Neurobiology of aging 2017 Jan;49:165-182
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Polo M, Alegre F, Moragrega AB, Gibellini L, Marti-Rodrigo A, Blas-Garcia A, Esplugues JV, Apostolova N
British journal of pharmacology 2017 Dec;174(23):4409-4429
British journal of pharmacology 2017 Dec;174(23):4409-4429
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M
Nature immunology 2017 Aug;18(8):899-910
Nature immunology 2017 Aug;18(8):899-910
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W
Molecular neurodegeneration 2017 Apr 24;12(1):32
Molecular neurodegeneration 2017 Apr 24;12(1):32
Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.
Gao J, Li M, Qin S, Zhang T, Jiang S, Hu Y, Deng Y, Zhang C, You D, Li H, Mu D, Zhang Z, Jiang C
Autophagy 2016;12(4):632-47
Autophagy 2016;12(4):632-47
Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.
Anand R, Strecker V, Urbach J, Wittig I, Reichert AS
PloS one 2016;11(8):e0160258
PloS one 2016;11(8):e0160258
Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.
Mot AI, Liddell JR, White AR, Crouch PJ
The international journal of biochemistry & cell biology 2016 Oct;79:128-138
The international journal of biochemistry & cell biology 2016 Oct;79:128-138
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92
Cell death and differentiation 2016 Mar;23(3):380-92
Incorporation of VSV-G produces fusogenic plasma membrane vesicles capable of efficient transfer of bioactive macromolecules and mitochondria.
Lin HP, Zheng DJ, Li YP, Wang N, Chen SJ, Fu YC, Xu WC, Wei CJ
Biomedical microdevices 2016 Jun;18(3):41
Biomedical microdevices 2016 Jun;18(3):41
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).
Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang WX, Kim C, Nelson PT, Springer W, Kim J
Molecular neurodegeneration 2016 Jul 26;11(1):55
Molecular neurodegeneration 2016 Jul 26;11(1):55
PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.
Chen Y, Deng J, Wang P, Yang M, Chen X, Zhu L, Liu J, Lu B, Shen Y, Fushimi K, Xu Q, Wu JY
Human molecular genetics 2016 Dec 1;25(23):5059-5068
Human molecular genetics 2016 Dec 1;25(23):5059-5068
Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development.
Deng Q, Guo T, Zhou X, Xi Y, Yang X, Ge W
Genetics 2016 Aug;203(4):1777-88
Genetics 2016 Aug;203(4):1777-88
Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis.
Li S, Wang J, Zhou A, Khan FA, Hu L, Zhang S
Oncotarget 2016 Aug 30;7(35):56002-56012
Oncotarget 2016 Aug 30;7(35):56002-56012
Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy.
Wang YH, Wang JQ, Wang Q, Wang Y, Guo C, Chen Q, Chai T, Tang TS
Scientific reports 2016 Apr 26;6:25153
Scientific reports 2016 Apr 26;6:25153
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, Cheng H, Li Y, Bigio EH, Mesulam M, Xu Q, Du S, Fushimi K, Zhu L, Wu JY
PLoS genetics 2015 Sep;11(9):e1005357
PLoS genetics 2015 Sep;11(9):e1005357
Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization.
Gao J, Qin S, Jiang C
Acta biochimica et biophysica Sinica 2015 Jul;47(7):522-9
Acta biochimica et biophysica Sinica 2015 Jul;47(7):522-9
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K
Nature communications 2015 Jul 6;6:7527
Nature communications 2015 Jul 6;6:7527
Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin.
Fiesel FC, Caulfield TR, Moussaud-Lamodière EL, Ogaki K, Dourado DF, Flores SC, Ross OA, Springer W
Human mutation 2015 Aug;36(8):774-86
Human mutation 2015 Aug;36(8):774-86
Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Wei B, Cui Y, Huang Y, Liu H, Li L, Li M, Ruan KC, Zhou Q, Wang C
Journal of virology 2015 Apr;89(7):3804-18
Journal of virology 2015 Apr;89(7):3804-18
Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.
Caulfield TR, Fiesel FC, Moussaud-Lamodière EL, Dourado DF, Flores SC, Springer W
PLoS computational biology 2014 Nov;10(11):e1003935
PLoS computational biology 2014 Nov;10(11):e1003935
MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infection.
Huang Y, Liu H, Li S, Tang Y, Wei B, Yu H, Wang C
PLoS pathogens 2014 Mar;10(3):e1004020
PLoS pathogens 2014 Mar;10(3):e1004020
MicroRNA directly enhances mitochondrial translation during muscle differentiation.
Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD
Cell 2014 Jul 31;158(3):607-19
Cell 2014 Jul 31;158(3):607-19
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
Fiesel FC, Moussaud-Lamodière EL, Ando M, Springer W
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism.
Lai D, Tan CL, Gunaratne J, Quek LS, Nei W, Thierry F, Bellanger S
PloS one 2013;8(9):e75625
PloS one 2013;8(9):e75625
Mitochondrial abnormalities in temporal lobe of autistic brain.
Tang G, Gutierrez Rios P, Kuo SH, Akman HO, Rosoklija G, Tanji K, Dwork A, Schon EA, Dimauro S, Goldman J, Sulzer D
Neurobiology of disease 2013 Jun;54:349-61
Neurobiology of disease 2013 Jun;54:349-61
UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria.
Huang Y, Liu H, Ge R, Zhou Y, Lou X, Wang C
Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 1;188(1):358-66
Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 1;188(1):358-66
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
Liu XY, Wei B, Shi HX, Shan YF, Wang C
Cell research 2010 Sep;20(9):994-1011
Cell research 2010 Sep;20(9):994-1011
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 11802-1-AP( TOM20 Antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TOM20 (IP:11802-1-AP, 3ug; Detection:11802-1-AP 1:2000) with HEK-293 cells lysate 2400ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TOM20 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TOM20. This antibody recognizes human, mouse antigen. The TOM20 antibody has been validated for the following applications: ELISA, IHC, WB, IP analysis.