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- Antibody Data
- Antigen structure
- References [34]
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- Product number
- 20507-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20507-1-AP, RRID:AB_10694284
- Product name
- DMT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DMT1 antibody (Cat. #20507-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier.
Resistance to disuse-induced iron overload in Daurian ground squirrels (Spermophilus dauricus) during extended hibernation inactivity.
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.
Tolerable upper intake level of iron damages the liver of weaned piglets.
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro.
Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.
Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts.
Tolerable upper intake level of iron damages the intestine and alters the intestinal flora in weaned piglets.
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.
Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins.
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter.
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
The Effects of the Combination of Oral Lactoferrin and Iron Injection on Iron Homestasis, Antioxidative Abilities and Cytokines Activities of Suckling Piglets.
S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.
The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells.
The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.
A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria.
Liu LL, Du D, Zheng W, Zhang Y
Neurotoxicology 2022 Jan;88:44-56
Neurotoxicology 2022 Jan;88:44-56
Resistance to disuse-induced iron overload in Daurian ground squirrels (Spermophilus dauricus) during extended hibernation inactivity.
Yin R, Zhang J, Xu S, Kong Y, Wang H, Gao Y
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2022 Jan;257:110650
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2022 Jan;257:110650
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Lu S, Song Y, Luo R, Li S, Li G, Wang K, Liao Z, Wang B, Ke W, Xiang Q, Chen C, Wu X, Zhang Y, Ling L, Yang C
Oxidative medicine and cellular longevity 2021;2021:6670497
Oxidative medicine and cellular longevity 2021;2021:6670497
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Song Q, Peng S, Sun Z, Heng X, Zhu X
Yonsei medical journal 2021 Sep;62(9):843-849
Yonsei medical journal 2021 Sep;62(9):843-849
Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.
Zimmer TS, David B, Broekaart DWM, Schidlowski M, Ruffolo G, Korotkov A, van der Wel NN, van Rijen PC, Mühlebner A, van Hecke W, Baayen JC, Idema S, François L, van Eyll J, Dedeurwaerdere S, Kessels HW, Surges R, Rüber T, Gorter JA, Mills JD, van Vliet EA, Aronica E
Acta neuropathologica 2021 Oct;142(4):729-759
Acta neuropathologica 2021 Oct;142(4):729-759
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.
Wang L, Ouyang S, Li B, Wu H, Wang F
Cell death discovery 2021 Nov 3;7(1):334
Cell death discovery 2021 Nov 3;7(1):334
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.
Yang G, Qian C, Zhang C, Bao Y, Liu MY, Jiang F, Li W, Liu Y, Ke Y, Qian ZM
Translational research : the journal of laboratory and clinical medicine 2021 Mar;229:53-68
Translational research : the journal of laboratory and clinical medicine 2021 Mar;229:53-68
Tolerable upper intake level of iron damages the liver of weaned piglets.
Ding H, Zhao Y, Yu X, Chen L, Han J, Feng J
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.
Song Q, Zhao Y, Yang Y, Han X, Duan J
Toxicology and applied pharmacology 2021 Jan 1;410:115361
Toxicology and applied pharmacology 2021 Jan 1;410:115361
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z
Experimental and molecular pathology 2021 Feb;118:104570
Experimental and molecular pathology 2021 Feb;118:104570
Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Song Q, Peng S, Zhu X
Neurotoxicology 2021 Dec;87:188-194
Neurotoxicology 2021 Dec;87:188-194
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Xiang T, Luo X, Zeng C, Li S, Ma M, Wu Y
Brain research 2021 Dec 1;1772:147668
Brain research 2021 Dec 1;1772:147668
Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro.
Song Q, Zhang F, Han X, Yang Y, Zhao Y, Duan J
Experimental eye research 2021 Aug;209:108642
Experimental eye research 2021 Aug;209:108642
Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.
Ma J, Qian C, Bao Y, Liu MY, Ma HM, Shen MQ, Li W, Wang JJ, Bao YX, Liu Y, Ke Y, Qian ZM
Redox biology 2021 Apr;40:101865
Redox biology 2021 Apr;40:101865
Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts.
Petit F, Drecourt A, Dussiot M, Zangarelli C, Hermine O, Munnich A, Rötig A
Blood 2021 Apr 15;137(15):2090-2102
Blood 2021 Apr 15;137(15):2090-2102
Tolerable upper intake level of iron damages the intestine and alters the intestinal flora in weaned piglets.
Ding H, Yu X, Chen L, Han J, Zhao Y, Feng J
Metallomics : integrated biometal science 2020 Sep 23;12(9):1356-1369
Metallomics : integrated biometal science 2020 Sep 23;12(9):1356-1369
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.
Yamaguchi H, Honda S, Torii S, Shimizu K, Katoh K, Miyake K, Miyake N, Fujikake N, Sakurai HT, Arakawa S, Shimizu S
Nature communications 2020 Oct 20;11(1):5311
Nature communications 2020 Oct 20;11(1):5311
Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Li Y, Jin C, Shen M, Wang Z, Tan S, Chen A, Wang S, Shao J, Zhang F, Zhang Z, Zheng S
Free radical biology & medicine 2020 Nov 20;160:845-859
Free radical biology & medicine 2020 Nov 20;160:845-859
Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins.
Song Q, Zhao Y, Li Q, Han X, Duan J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109690
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109690
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K
Molecular cell 2020 Feb 6;77(3):645-655.e7
Molecular cell 2020 Feb 6;77(3):645-655.e7
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Morgan SE, Schroten H, Ishikawa H, Zhao N
Brain sciences 2020 Aug 8;10(8)
Brain sciences 2020 Aug 8;10(8)
Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.
Guo C, Xue H, Guo T, Zhang W, Xuan WQ, Ren YT, Wang D, Chen YH, Meng YH, Gao HL, Zhao P
Food & function 2020 Aug 1;11(8):7183-7196
Food & function 2020 Aug 1;11(8):7183-7196
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Li S, Qian ZM, Xu G, Zheng J, Wu Y
Bioscience reports 2020 Apr 30;40(4)
Bioscience reports 2020 Apr 30;40(4)
Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter.
Zhao P, Qian C, Chen YJ, Sheng Y, Ke Y, Qian ZM
Cell death & disease 2019 Sep 24;10(10):708
Cell death & disease 2019 Sep 24;10(10):708
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
Scheiber IF, Wu Y, Morgan SE, Zhao N
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
The Effects of the Combination of Oral Lactoferrin and Iron Injection on Iron Homestasis, Antioxidative Abilities and Cytokines Activities of Suckling Piglets.
Hu P, Zhao D, Zhao F, Wang J, Zhu W
Animals : an open access journal from MDPI 2019 Jul 11;9(7)
Animals : an open access journal from MDPI 2019 Jul 11;9(7)
S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.
Liu C, Zhang CW, Lo SQ, Ang ST, Chew KCM, Yu D, Chai BH, Tan B, Tsang F, Tai YK, Tan BWQ, Liang MC, Tan HT, Tang JY, Lai MKP, Chua JJE, Chung MCM, Khanna S, Lim KL, Soong TW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Sep 26;38(39):8364-8377
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Sep 26;38(39):8364-8377
The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.
Yang L, Wang D, Wang XT, Lu YP, Zhu L
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):128-135
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):128-135
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Zhang MW, Zhao P, Yung WH, Sheng Y, Ke Y, Qian ZM
Aging 2018 Dec 16;10(12):3834-3850
Aging 2018 Dec 16;10(12):3834-3850
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Zhou YF, Zhang C, Yang G, Qian ZM, Zhang MW, Ma J, Zhang FL, Ke Y
Frontiers in physiology 2017;8:332
Frontiers in physiology 2017;8:332
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells.
Chen P, Li FM, Zhou YF, Qian C, Li J, Jiang LR, Qian ZM
Pharmacological reports : PR 2017 Feb;69(1):1-5
Pharmacological reports : PR 2017 Feb;69(1):1-5
The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.
Zhao N, Zhang AS, Wortham AM, Jue S, Knutson MD, Enns CA
Nutrients 2017 Dec 8;9(12)
Nutrients 2017 Dec 8;9(12)
A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria.
Geng J, Li J, Huang T, Zhao K, Chen Q, Guo W, Gao J
Molecular medicine reports 2016 Sep;14(3):1970-8
Molecular medicine reports 2016 Sep;14(3):1970-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SLC11A2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SLC11A2. This antibody recognizes human, mouse, rat antigen. The SLC11A2 antibody has been validated for the following applications: ELISA, WB analysis.
