Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 12020-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12020-1-AP, RRID:AB_2195380
- Product name
- SPATA7 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SPATA7 antibody (Cat. #12020-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice.
Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina.
AAV8(Y733F)-mediated gene therapy in a Spata7 knockout mouse model of Leber congenital amaurosis and retinitis pigmentosa.
Mutations in SPATA7 cause Leber congenital amaurosis and juvenile retinitis pigmentosa.
Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Moayedi Y, Mardon G, Chen R
Experimental eye research 2018 Jan;166:120-130
Experimental eye research 2018 Jan;166:120-130
Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina.
Eblimit A, Nguyen TM, Chen Y, Esteve-Rudd J, Zhong H, Letteboer S, Van Reeuwijk J, Simons DL, Ding Q, Wu KM, Li Y, Van Beersum S, Moayedi Y, Xu H, Pickard P, Wang K, Gan L, Wu SM, Williams DS, Mardon G, Roepman R, Chen R
Human molecular genetics 2015 Mar 15;24(6):1584-601
Human molecular genetics 2015 Mar 15;24(6):1584-601
AAV8(Y733F)-mediated gene therapy in a Spata7 knockout mouse model of Leber congenital amaurosis and retinitis pigmentosa.
Zhong H, Eblimit A, Moayedi Y, Boye SL, Chiodo VA, Chen Y, Li Y, Nichols RM, Hauswirth WW, Chen R, Mardon G
Gene therapy 2015 Aug;22(8):619-27
Gene therapy 2015 Aug;22(8):619-27
Mutations in SPATA7 cause Leber congenital amaurosis and juvenile retinitis pigmentosa.
Wang H, den Hollander AI, Moayedi Y, Abulimiti A, Li Y, Collin RW, Hoyng CB, Lopez I, Abboud EB, Al-Rajhi AA, Bray M, Lewis RA, Lupski JR, Mardon G, Koenekoop RK, Chen R
American journal of human genetics 2009 Mar;84(3):380-7
American journal of human genetics 2009 Mar;84(3):380-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 12020-1-AP(SPATA7 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SPATA7 (IP:12020-1-AP, 3ug; Detection:12020-1-AP 1:300) with mouse testis tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 12020-1-AP(SPATA7 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SPATA7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SPATA7. This antibody recognizes human, mouse antigen. The SPATA7 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.