BID

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]

Description

BH3 interacting domain death agonist

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (17734138 - 17774770)

Ensembl ID

ENSG00000015475  (ver. 103.38)

Orthologs

Mouse Bid: ENSMUSG00000004446

UniProt

P55957

neXtProt

NX_P55957

Human splice variants
Mouse splice variants

Protein structure