BS8200

antibody from Bioworld Technology, Inc
Targeting: KLF10 EGRA, TIEG, TIEG1
Provider product page for BS8200
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8200 - Provider product page
Provider
Bioworld Technology, Inc
Product name
KLF10 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human KLF10.
Description
Originally isolated from osteoblastic cells, the TGFÉÇ-inducible early gene-1 (TIEG1) is a Krupel-like zinc finger transcription factor-encoding gene which regulates cellular growth and differentiation. TIEG1 is regulated as an early response gene by TGFÉÇ1. It is expressed in both acinar and ductular epithelial cells from exocrine pancreas and may serve as an early response gene in pancreatic cell lines. Further, overexpression of TIEG1 in TGFÉÇ-sensitive epithelial cells induces apoptosis. TIEG1 and EGRa are expressed from alternate promoters of the same gene. Both are highly expressed in human fetal osteoblast cells. TIEG1 is additionally expressed at high levels in PBLs, spleen and colon, and at lower levels in thymus, small intestine, ovary, prostate and skeletal muscle. The nuclear TIEG2 protein, which shares significant homology with TIEG1, was originally isolated from globin-expressing human fetal erythroid cells. TIEG2 is also expressed in fetal liver. Overexpression of TIEG2 in cultured epithelial cells inhibits cellular proliferation. TIEG2 expression is upregulated by TGFÉÇ1 and serum deprivation.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
KLF10 protein structure - BS8200 shown in red.