BS61196

antibody from Bioworld Technology, Inc
Targeting: GADD45GIP1 CKBBP2, CKbetaBP2, CRIF1, MGC4667, MGC4758, PLINP-1, Plinp1, PRG6
Provider product page for BS61196

Antibody data

Product number
BS61196 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GADD45GIP1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human GADD45GIP1.
Description
CRIF1, also known as GADD45GIP1, PLINP1, PRG6 or CKBBP2, is a 222 amino acid nuclear protein that plays a role in apoptosis control. Expressed in a variety of tissues, including heart, thyroid, trachea, kidney, ovary, pancreas, testis and stomach, CRIF1 functions as a negative regulator of G1 to S phase cell cycle production, specifically by working with GADD 45 proteins to inhibit the activity of cyclin-dependent kinases (Cdks). While overexpression of CRIF1 results in cell cycle arrest at the G1 phase, downregulation of CRIF1 by p53 in apoptotic cells promotes cell cycle progression and may be an important factor in tumor growth and metastasis. CRIF1 is subject to phosphorylation by casein kinase II, an event that is thought to decrease CRIF1 activity and promote cellular proliferation. Human CRIF1 shares 90% homology with its mouse counterpart, suggesting a conserved role between species.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GADD45GIP1 protein structure - BS61196 shown in red.