BS60790

antibody from Bioworld Technology, Inc
Targeting: SCN8A CerIII, CIAT, MED, NaCh6, Nav1.6, PN4
Provider product page for BS60790

Antibody data

Product number
BS60790 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SCN8A polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human SCN8A
Description
The sodium channel protein type 8 subunit alpha (Na+ CP type VIIIÏ« ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming Ï« subunit, a noncovalently associated ÉÇ1 subunit and a disulfide-linked ÉÇ2 subunit. The two ÉÇ subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The Ï« subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIÏ« subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SCN8A protein structure - BS60790 shown in red.