Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AMM01209G - Provider product page
- Provider
- Leading Biology
- Product name
- UACA / Nucling (Nuclear Membrane Marker) Antibody - With BSA and Azide
- Antibody type
- Monoclonal
- Description
- UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Antibody clone number
- AE-5
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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