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TDP1
Tyrosyl-DNA phosphodiesterase 1FLJ11090, SCAN1
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]
Top validated antibodies |
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| Novus Biologicals |  NB100-81642 |
2 references | Polyclonal |
WB
IP
IHC
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| Proteintech Group | 10641-1-AP |
2 references | Polyclonal |
WB
EL
IP
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| antibodies-online | ABIN257087 |
2 references | Polyclonal |
WB
IP
IHC
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| Cusabio Biotech Co., Ltd | CSB-PA023352ESR1HU |
Polyclonal |
WB
EL
IP
IHC
|
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| GeneTex | GTX100126 |
Polyclonal |
WB
ICC
IHC
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