Explore
Validate
Learn
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Other assay [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- PA5-62137 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- eIF3c Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full-length protein
- Description
- Immunogen sequence: NELMDILFAN PNIFVGENIL EESENLHNAD QPLRVRGCIL TLVERMDEEF TKIMQNTDPH SQEYVEHLKD EAQVCAIIER VQRYLEEKGT TE
- Concentration
- 0.4 mg/mL
Submitted references Knockdown of EIF3C promotes human U-2OS cells apoptosis through increased CASP3/7 and Chk1/2 by upregulating SAPK/JNK.
Decreasing Eukaryotic Initiation Factor 3C (EIF3C) Suppresses Proliferation and Stimulates Apoptosis in Breast Cancer Cell Lines Through Mammalian Target of Rapamycin (mTOR) Pathway.
Gao W, Hu Y, Zhang Z, Du G, Yin L, Yin Z
OncoTargets and therapy 2019;12:1225-1235
OncoTargets and therapy 2019;12:1225-1235
Decreasing Eukaryotic Initiation Factor 3C (EIF3C) Suppresses Proliferation and Stimulates Apoptosis in Breast Cancer Cell Lines Through Mammalian Target of Rapamycin (mTOR) Pathway.
Zhao W, Li X, Wang J, Wang C, Jia Y, Yuan S, Huang Y, Shi Y, Tong Z
Medical science monitor : international medical journal of experimental and clinical research 2017 Aug 30;23:4182-4191
Medical science monitor : international medical journal of experimental and clinical research 2017 Aug 30;23:4182-4191
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of eIF3c in Lane 1: Marker (kDa) 250, 130, 95, 72, 55, 36, 28, 17, 10; Lane 2: Human cell line RT-4; Lane 3: Human cell line U-251 MG. Samples were probed using an EIF3c Polyclonal Antibody (Product # PA5-62137).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of eIF3c in human rectal tissue shows strong cytoplasmic positivity in glandular cells. Samples were probed using an EIF3c Polyclonal Antibody (Product # PA5-62137).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 1 Expression of EIF3C and Ki-67 in breast cancer tissues. ( A, C, E ) EIF3C antigen expression in breast cancer tissues. Low expression in A, moderate expression in C and high expression in E . ( B, D, F ) Positive nuclear Ki-67 staining in breast cancer tissues. Low expression in B , moderate expression in D and high expression in F . (SP, magnification, 400x).
