Antibody data
- Antibody Data
- Antigen structure
- References [357]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 10701-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10701-1-AP, RRID:AB_2118685
- Product name
- HO-1/HMOX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HO-1/HMOX1 antibody (Cat. #10701-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway.
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Synthesis and biological evaluation of novel schisanhenol derivatives as potential hepatoprotective agents.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischaemia.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.
Gastrodin Promotes the Survival of Random-Pattern Skin Flaps via Autophagy Flux Stimulation.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis.
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway.
Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis.
Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats.
Compound essential oils relieve oxidative stress caused by PM2 .5 exposure by inhibiting autophagy through the AMPK/mTOR pathway.
N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder.
Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.
The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway.
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Effects of Bacillus subtilis on jejunal integrity, redox status, and microbial composition of intrauterine growth restriction suckling piglets.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia.
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.
Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure.
An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury.
Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Autophagy deficiency exacerbates acute lung injury induced by copper oxide nanoparticles.
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress.
Cordyceps acid alleviates lung cancer in nude mice.
Chondrocyte ferroptosis contribute to the progression of osteoarthritis.
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption.
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro.
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Protective effect of scorpion venom heat-resistant synthetic peptide against PM2.5-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
A novel PGAM5 inhibitor LFHP-1c protects blood-brain barrier integrity in ischemic stroke.
Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury.
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Polydatin mitigates pancreatic β-cell damage through its antioxidant activity.
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers.
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway.
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Design, synthesis, and evaluation of mono-carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis.
The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl4-induced liver injury in vivo.
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease.
A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis.
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Myricetin protects against H2 O2 -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation.
Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells.
Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system.
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κ B Pathway.
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
Heme Oxygenase-1-Mediated Autophagy Protects against Oxidative Damage in Rat Nucleus Pulposus-Derived Mesenchymal Stem Cells.
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Inhibition of Brd4 by JQ1 Promotes Functional Recovery From Spinal Cord Injury by Activating Autophagy.
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.
Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway.
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Kaempferol Protects Blood Vessels From Damage Induced by Oxidative Stress and Inflammation in Association With the Nrf2/HO-1 Signaling Pathway.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway.
Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia reperfusion in mice.
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way.
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D3 Plus Nicotine.
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation.
Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway.
Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats.
7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway.
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role.
Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System.
Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM2.5 from Beijing, China, in Winter.
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Bach1-induced suppression of angiogenesis is dependent on the BTB domain.
Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upregulating the Nrf2/HO-1/CO Pathway to Inhibit Connexin 43 Expression.
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Polychlorinated biphenyl quinone promotes macrophage polarization to CD163+ cells through Nrf2 signaling pathway.
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8+CD28- T cells.
H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron.
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Syringin protects against colitis by ameliorating inflammation.
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling.
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Silibinin ameliorats H2O2-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Brainstem iron overload and injury in a rat model of brainstem hemorrhage.
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells.
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Inhibition of Mitochondrial Complex I Aggravates Folic Acid-Induced Acute Kidney Injury.
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Prevention of Huntington's Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress.
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress.
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
FGF10 Enhances Peripheral Nerve Regeneration via the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant Response.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways.
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity.
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Predictable chronic mild stress promotes recovery from LPS-induced depression.
Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
The harmful effects of acute PM2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs.
Neuroprotective Effect of Dioscin on the Aging Brain.
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
14-3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling.
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks.
Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms.
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Dietary Dihydroartemisinin Supplementation Attenuates Hepatic Oxidative Damage of Weaned Piglets with Intrauterine Growth Retardation through the Nrf2/ARE Signaling Pathway.
Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Deferoxamine Alleviates Iron Overload and Brain Injury in a Rat Model of Brainstem Hemorrhage.
NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Ochratoxin A causes mitochondrial dysfunction, apoptotic and autophagic cell death and also induces mitochondrial biogenesis in human gastric epithelium cells.
Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells.
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Liver injury induced in Balb/c mice by PM2.5 exposure and its alleviation by compound essential oils.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Cyclooxygenase‑2‑mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium‑tritium fusion radiation.
Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells.
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88's effects on the gut microbiota.
Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2.
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.
Non-Lethal Sonodynamic Therapy Inhibits Atherosclerotic Plaque Progression in ApoE-/- Mice and Attenuates ox-LDL-mediated Macrophage Impairment by Inducing Heme Oxygenase-1.
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: Role of oxidative stress and endoplasmic reticulum stress.
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Establishment and characterization of human osteosarcoma cells resistant to pyropheophorbide-α methyl ester-mediated photodynamic therapy.
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
Role of the cystathionine β-synthase/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system.
Effect of ozone oxidative preconditioning on oxidative stress injury in a rat model of kidney transplantation.
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis.
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Global Transcriptomic Profiling of Cortex and Striatum: Cerebral Injury after Ischemia/Reperfusion in a Mouse Model.
The electrophilic character of quinones is essential for the suppression of Bach1.
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Heme-oxygenase-1 Production by Intestinal CX3CR1+ Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis.
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway.
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis.
Desferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1.
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
High expression of heme oxygenase-1 in target organs may attenuate acute graft-versus-host disease through regulation of immune balance of TH17/Treg.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats.
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell.
Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo.
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Potent effects of dioscin against obesity in mice.
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Heme oxygenase-1 silencing increases the sensitivity of human osteosarcoma MG63 cells to arsenic trioxide.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response.
Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection.
Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.
Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways.
Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium.
Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC.
Wen Y, Liu Y, Huang Q, Liu R, Liu J, Zhang F, Liu S, Jiang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153856
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153856
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Lou J, Zhang H, Qi J, Xu Y, Wang X, Jiang J, Hu X, Ni L, Cai Y, Wang X, Gao W, Xiao J, Zhou K
British journal of pharmacology 2022 Jan;179(2):301-321
British journal of pharmacology 2022 Jan;179(2):301-321
Synthesis and biological evaluation of novel schisanhenol derivatives as potential hepatoprotective agents.
Deng L, Cheng S, Li J, Xu X, Hao X, Fan Y, Mu S
European journal of medicinal chemistry 2022 Jan 5;227:113919
European journal of medicinal chemistry 2022 Jan 5;227:113919
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Wu X, Zhang T, Lyu P, Chen M, Ni G, Cheng H, Xu G, Li X, Wang L, Shang H
Frontiers in cardiovascular medicine 2021;8:698056
Frontiers in cardiovascular medicine 2021;8:698056
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischaemia.
Kuo PC, Weng WT, Scofield BA, Furnas D, Paraiso HC, Yu IC, Yen JH
Brain communications 2021;3(3):fcab187
Brain communications 2021;3(3):fcab187
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.
Lu Y, Zhang W, Zhang B, Heinemann SH, Hoshi T, Hou S, Zhang G
Oxidative medicine and cellular longevity 2021;2021:8869908
Oxidative medicine and cellular longevity 2021;2021:8869908
Gastrodin Promotes the Survival of Random-Pattern Skin Flaps via Autophagy Flux Stimulation.
Chen H, Chen B, Li B, Luo X, Wu H, Zhang C, Liu J, Jiang J, Zhao B
Oxidative medicine and cellular longevity 2021;2021:6611668
Oxidative medicine and cellular longevity 2021;2021:6611668
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis.
Zhao X, Li S, Mo Y, Li R, Huang S, Zhang A, Ni X, Dai Q, Wang J
Oxidative medicine and cellular longevity 2021;2021:5173035
Oxidative medicine and cellular longevity 2021;2021:5173035
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Lin Y, Xie Y, Hao Z, Bi H, Liu Y, Yang X, Xia Y
Journal of immunology research 2021;2021:5151168
Journal of immunology research 2021;2021:5151168
Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.
Wang H, Zhao K, Ba Y, Gao T, Shi N, Niu Q, Liu C, Chen Y
Oxidative medicine and cellular longevity 2021;2021:1298657
Oxidative medicine and cellular longevity 2021;2021:1298657
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.
Zou L, Cheng G, Xu C, Liu H, Wang Y, Li N, Fan X, Zhu C, Xia W
International journal of nanomedicine 2021;16:1565-1573
International journal of nanomedicine 2021;16:1565-1573
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Wang H, Jiang Z, Pang Z, Qi G, Hua B, Yan Z, Yuan H
Journal of inflammation research 2021;14:745-760
Journal of inflammation research 2021;14:745-760
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Tu Z, Jiang X, Li Y, Yang S, Lin D, Shi Y, Mao C, Zhang X, Lin C
American journal of translational research 2021;13(3):1337-1351
American journal of translational research 2021;13(3):1337-1351
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Zhou F, Zhang X, Jiang L, Li S, Chen Y, Wu J
Frontiers in pharmacology 2021;12:667524
Frontiers in pharmacology 2021;12:667524
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Li R, Yang W, Yin Y, Ma X, Zhang P, Tao K
Frontiers in pharmacology 2021;12:651444
Frontiers in pharmacology 2021;12:651444
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway.
Chen Y, Zhang F, Du Z, Xie J, Xia L, Hou X, Hao E, Deng J
Frontiers in oncology 2021;11:727130
Frontiers in oncology 2021;11:727130
Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis.
Chen G, Yang Z, Wen D, Guo J, Xiong Q, Li P, Zhao L, Wang J, Wu C, Dong L
Immunity, inflammation and disease 2021 Sep;9(3):959-970
Immunity, inflammation and disease 2021 Sep;9(3):959-970
Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats.
Kong Y, Li S, Zhang M, Xu W, Chen Q, Zheng L, Liu P, Zou W
Journal of molecular neuroscience : MN 2021 Sep;71(9):1863-1875
Journal of molecular neuroscience : MN 2021 Sep;71(9):1863-1875
Compound essential oils relieve oxidative stress caused by PM2 .5 exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Ren F, Xu X, Xu J, Mei Y, Zhang J, Wang X, Li F
Environmental toxicology 2021 Sep;36(9):1765-1774
Environmental toxicology 2021 Sep;36(9):1765-1774
N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
Peng W, Zhu Z, Yang Y, Hou J, Lu J, Chen C, Liu F, Pi R
Brain research bulletin 2021 Sep;174:250-259
Brain research bulletin 2021 Sep;174:250-259
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Cui M, Atmanli A, Morales MG, Tan W, Chen K, Xiao X, Xu L, Liu N, Bassel-Duby R, Olson EN
Nature communications 2021 Sep 6;12(1):5270
Nature communications 2021 Sep 6;12(1):5270
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Zhang M, Hou G, Hu P, Feng D, Wang J, Zhu W
The British journal of nutrition 2021 Sep 28;126(6):801-812
The British journal of nutrition 2021 Sep 28;126(6):801-812
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Li R, Qi Y, Yuan Q, Xu L, Gao M, Xu Y, Han X, Yin L, Liu C
European journal of pharmacology 2021 Sep 15;907:174277
European journal of pharmacology 2021 Sep 15;907:174277
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Wen L, Yang QH, Ma XL, Li T, Xiao S, Sun CF
International immunopharmacology 2021 Oct;99:107993
International immunopharmacology 2021 Oct;99:107993
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Fan S, Liu X, Wang Y, Ren X, Liu Y, Dong Y, Fan Q, Wei J, Ma J, Yu A, Song R, Sui H, Shen M, Fang F, Xia Q, She G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder.
Di Nardo A, Rühmkorf A, Award P, Brennecke A, Fagiolini M, Sahin M
Neuroscience research 2021 Oct 5;
Neuroscience research 2021 Oct 5;
Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.
Potor L, Hendrik Z, Patsalos A, Katona É, Méhes G, Póliska S, Csősz É, Kalló G, Komáromi I, Combi Z, Posta N, Sikura KÉ, Pethő D, Oros M, Vereb G, Tóth C, Gergely P, Nagy L, Balla G, Balla J
Antioxidants & redox signaling 2021 Oct 20;35(12):917-950
Antioxidants & redox signaling 2021 Oct 20;35(12):917-950
The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway.
Guo X, Cao P, Lian X, Hu M, Zhao J, Shen W, Wang H, Yu H, Chen Y
European journal of pharmacology 2021 Oct 15;909:174439
European journal of pharmacology 2021 Oct 15;909:174439
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Kong L, Deng J, Zhou X, Cai B, Zhang B, Chen X, Chen Z, Wang W
Cell death & disease 2021 Oct 11;12(10):928
Cell death & disease 2021 Oct 11;12(10):928
Effects of Bacillus subtilis on jejunal integrity, redox status, and microbial composition of intrauterine growth restriction suckling piglets.
Yun Y, Ji S, Yu G, Jia P, Niu Y, Zhang H, Zhang X, Wang T, Zhang L
Journal of animal science 2021 Oct 1;99(10)
Journal of animal science 2021 Oct 1;99(10)
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia.
Chen Q, Xu Z, Li X, Du D, Wu T, Zhou S, Yan W, Wu M, Jin Y, Zhang J, Wang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153752
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153752
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
Nature 2021 Nov;599(7883):136-140
Nature 2021 Nov;599(7883):136-140
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
He R, Wang Z, Cui M, Liu S, Wu W, Chen M, Wu Y, Qu Y, Lin H, Chen S, Wang B, Shao Z
Autophagy 2021 Nov;17(11):3338-3360
Autophagy 2021 Nov;17(11):3338-3360
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Liu Y, Zhou J, Luo Y, Li J, Shang L, Zhou F, Yang S
Chinese medicine 2021 Nov 29;16(1):127
Chinese medicine 2021 Nov 29;16(1):127
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.
Feng J, Liu Z, Chen H, Zhang M, Ma X, Han Q, Lu D, Wang C
European journal of pharmacology 2021 Nov 15;911:174522
European journal of pharmacology 2021 Nov 15;911:174522
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.
Chen Y, Wang J, Li J, Zhu J, Wang R, Xi Q, Wu H, Shi T, Chen W
European journal of pharmacology 2021 Nov 15;911:174518
European journal of pharmacology 2021 Nov 15;911:174518
Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure.
Zhou F, Song Y, Liu X, Zhang C, Li F, Hu R, Huang Y, Ma W, Song K, Zhang M
Journal of ethnopharmacology 2021 Nov 15;280:114431
Journal of ethnopharmacology 2021 Nov 15;280:114431
An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury.
Mu X, Wang J, He H, Li Q, Yang B, Wang J, Liu H, Gao Y, Ouyang L, Sun S, Ren Q, Shi X, Hao W, Fei Q, Yang J, Li L, Vest R, Wyss-Coray T, Luo J, Zhang XD
Science advances 2021 Nov 12;7(46):eabk1210
Science advances 2021 Nov 12;7(46):eabk1210
Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway.
Shi J, Yu T, Song K, Du S, He S, Hu X, Li X, Li H, Dong S, Zhang Y, Xie Z, Li C, Yu J
Redox biology 2021 May;41:101954
Redox biology 2021 May;41:101954
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
Sun B, Jiang J, Zhu X, Yang D, Cui Z, Zhang Y, Zhang M, Qian Y, Liu R, Yang W
Experimental and therapeutic medicine 2021 May;21(5):471
Experimental and therapeutic medicine 2021 May;21(5):471
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Zhou W, Xu C, Dong G, Qiao H, Yang J, Liu H, Ding L, Sun K, Zhao W
European journal of medicinal chemistry 2021 May 5;217:113326
European journal of medicinal chemistry 2021 May 5;217:113326
Autophagy deficiency exacerbates acute lung injury induced by copper oxide nanoparticles.
Xiao J, Tu B, Zhou X, Jiang X, Xu G, Zhang J, Qin X, Sumayyah G, Fan J, Wang B, Chen C, Zou Z
Journal of nanobiotechnology 2021 May 31;19(1):162
Journal of nanobiotechnology 2021 May 31;19(1):162
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Molecules (Basel, Switzerland) 2021 May 17;26(10)
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
Weng WT, Kuo PC, Brown DA, Scofield BA, Furnas D, Paraiso HC, Wang PY, Yu IC, Yen JH
Journal of neuroinflammation 2021 May 11;18(1):110
Journal of neuroinflammation 2021 May 11;18(1):110
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
Feng XH, Xu HY, Wang JY, Duan S, Wang YC, Ma CM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress.
Wang BN, Wu CB, Chen ZM, Zheng PP, Liu YQ, Xiong J, Xu JY, Li PF, Mamun AA, Ye LB, Zheng ZL, Wu YQ, Xiao J, Wang J
Acta pharmacologica Sinica 2021 Mar;42(3):347-360
Acta pharmacologica Sinica 2021 Mar;42(3):347-360
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Chondrocyte ferroptosis contribute to the progression of osteoarthritis.
Yao X, Sun K, Yu S, Luo J, Guo J, Lin J, Wang G, Guo Z, Ye Y, Guo F
Journal of orthopaedic translation 2021 Mar;27:33-43
Journal of orthopaedic translation 2021 Mar;27:33-43
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Sun Y, He L, Wang W, Wang T, Hua W, Li T, Wang L, Gao T, Chen F, Tang L
Journal of ethnopharmacology 2021 Mar 25;268:113617
Journal of ethnopharmacology 2021 Mar 25;268:113617
FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Wang D, Yin Y, Wang S, Zhao T, Gong F, Zhao Y, Wang B, Huang Y, Cheng Z, Zhu G, Wang Z, Wang Y, Ren J, Liang G, Li X, Huang Z
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Wang W, Zhai D, Bai Y, Xue K, Deng L, Ma L, Du T, Ye Z, Qu D, Xiang A, Chen G, Zhao Y, Wang L, Lu Z
Cell death discovery 2021 Mar 23;7(1):58
Cell death discovery 2021 Mar 23;7(1):58
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X, Zhang X
Food & function 2021 Mar 21;12(6):2703-2714
Food & function 2021 Mar 21;12(6):2703-2714
Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption.
Zhang Z, Zhang Q, Li F, Xin Y, Duan Z
Biomolecules & therapeutics 2021 Mar 1;29(2):175-183
Biomolecules & therapeutics 2021 Mar 1;29(2):175-183
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Lu D, Le Y, Ding J, Dou X, Mao W, Zhu J
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Peng J, Jiang Z, Wu G, Cai Z, Du Q, Tao L, Zhang Y, Chen Y, Shen X
Journal of drug targeting 2021 Jun;29(5):520-530
Journal of drug targeting 2021 Jun;29(5):520-530
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Li X, Wang X, Miao L, Liu Y, Lin X, Guo Y, Yuan R, Tian H
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro.
Wang M, Ke Y, Li Y, Shan Z, Mi W, Cao Y, Feng W, Zheng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111305
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111305
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Liu YP, Yuan XY, Li XY, Wang Y, Sun ZB, Deng WH, Lei YD, Huang L, Jiang TY, Zhang ZH
Journal of applied toxicology : JAT 2021 Jun 6;
Journal of applied toxicology : JAT 2021 Jun 6;
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Li X, Wang X, Miao L, Guo Y, Yuan R, Tian H
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Liu Z, He Q, Liu Y, Zhang Y, Cui M, Peng H, Wang Y, Chen S, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2021 Jun 30;458:152838
Toxicology 2021 Jun 30;458:152838
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Dai C, Li H, Wang Y, Tang S, Velkov T, Shen J
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Protective effect of scorpion venom heat-resistant synthetic peptide against PM2.5-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Xu X, Xu H, Ren F, Huang L, Xu J, Li F
Journal of neuroimmunology 2021 Jun 15;355:577567
Journal of neuroimmunology 2021 Jun 15;355:577567
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Liu X, Li M, Zhu J, Huang W, Song J
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
Huang Z, Guo L, Huang L, Shi Y, Liang J, Zhao L
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
A novel PGAM5 inhibitor LFHP-1c protects blood-brain barrier integrity in ischemic stroke.
Gao C, Xu Y, Liang Z, Wang Y, Shang Q, Zhang S, Wang C, Ni M, Wu D, Huang Z, Pang T
Acta pharmaceutica Sinica. B 2021 Jul;11(7):1867-1884
Acta pharmaceutica Sinica. B 2021 Jul;11(7):1867-1884
Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.
Huang Q, Ouyang DS, Liu Q
FEBS open bio 2021 Jul 6;
FEBS open bio 2021 Jul 6;
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
Wu M, Chen W, Miao M, Jin Q, Zhang S, Bai M, Fan J, Zhang Y, Zhang A, Jia Z, Huang S
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.
Yang R, Shen YJ, Chen M, Zhao JY, Chen SH, Zhang W, Song JK, Li L, Du GH
Journal of Asian natural products research 2021 Jul 22;:1-12
Journal of Asian natural products research 2021 Jul 22;:1-12
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury.
Guo L, Zhang T, Wang F, Chen X, Xu H, Zhou C, Chen M, Yu F, Wang S, Yang D, Wu B
British journal of pharmacology 2021 Jan;178(2):328-345
British journal of pharmacology 2021 Jan;178(2):328-345
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Yang Y, Li J, Zhang L, Lin Z, Xiao H, Sun X, Zhang M, Liu P, Huang H
Pharmacological research 2021 Jan;163:105333
Pharmacological research 2021 Jan;163:105333
Polydatin mitigates pancreatic β-cell damage through its antioxidant activity.
Yousef AI, Shawki HH, El-Shahawy AA, El-Twab SMA, Abdel-Moneim A, Oishi H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111027
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111027
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.
Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, Birsoy K
Cell metabolism 2021 Jan 5;33(1):211-221.e6
Cell metabolism 2021 Jan 5;33(1):211-221.e6
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Lv H, Sun X, Jia H, Xu C
Food & function 2021 Jan 21;12(2):696-705
Food & function 2021 Jan 21;12(2):696-705
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Zhang J, Yang S, Guan H, Zhou J, Gao Y
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers.
Guo Y, Balasubramanian B, Zhao ZH, Liu WC
Poultry science 2021 Feb;100(2):844-857
Poultry science 2021 Feb;100(2):844-857
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Wang Z, Cai B, Cao C, Lv H, Dai Y, Zheng M, Zhao G, Peng Y, Gou W, Wang J, Liu D, Hu Y
Free radical biology & medicine 2021 Feb 20;164:249-257
Free radical biology & medicine 2021 Feb 20;164:249-257
Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.
Lu Q, Gu W, Luo C, Wang L, Hua W, Sun Y, Tang L
Journal of ethnopharmacology 2021 Feb 10;266:113454
Journal of ethnopharmacology 2021 Feb 10;266:113454
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115
Free radical biology & medicine 2021 Feb 1;163:102-115
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
Xu Y, Sang W, Zhong Y, Xue S, Yang M, Wang C, Lu H, Huan R, Mao X, Zhu L, He C, Ma J
Cell proliferation 2021 Dec;54(12):e13142
Cell proliferation 2021 Dec;54(12):e13142
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Chen N, Song S, Yang Z, Wu M, Mu L, Zhou T, Shi Y
Journal of diabetes and its complications 2021 Dec;35(12):108050
Journal of diabetes and its complications 2021 Dec;35(12):108050
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Song Z, Gao C, Jiang Q, Xu J, Xiong L, Liu K, Sun D, Li H, Chen L
Phytochemistry 2021 Dec;192:112971
Phytochemistry 2021 Dec;192:112971
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Bao S, Zheng H, Chen C, Zhang Y, Bao L, Yang B, Hou Y, Chen Y, Zhang Q, Pi J, Fu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Tong J, Fang J, Zhu T, Xiang P, Shang J, Chen L, Zhao J, Wang Y, Tong L, Sun M
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway.
Li Y, Guo L, Hou Z, Gong H, Yan M, Zhang B
Journal of ethnopharmacology 2021 Dec 5;281:114489
Journal of ethnopharmacology 2021 Dec 5;281:114489
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Hong Y, Zhou Y, Shen L, Wei Y, Long C, Fu Y, Wu H, Wang J, Wu Y, Wu S, Wei G
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Design, synthesis, and evaluation of mono-carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis.
Zhao Y, Zheng Z, Zhang M, Wang Y, Hu R, Lin W, Huang C, Xu C, Wu J, Deng H
Journal of periodontal research 2021 Aug;56(4):656-666
Journal of periodontal research 2021 Aug;56(4):656-666
The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
Tan Y, Cao H, Li Q, Sun J
Cell biology international 2021 Aug;45(8):1654-1665
Cell biology international 2021 Aug;45(8):1654-1665
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
Zhou H, Yao L, Jiang X, Sumayyah G, Tu B, Cheng S, Qin X, Zhang J, Zou Z, Chen C
Neurotoxicity research 2021 Aug;39(4):1160-1170
Neurotoxicity research 2021 Aug;39(4):1160-1170
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Hou X, Liu H, Ping Y, Zhang F, Zhi L, Jiang X, Zhang F, Song C, Zhang Z, Song J
Brain research bulletin 2021 Aug;173:74-81
Brain research bulletin 2021 Aug;173:74-81
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
Jin J, He H, Zhang X, Wu R, Gan L, Li D, Lu Y, Wu P, Wong WL, Zhang K
Bioorganic chemistry 2021 Aug;113:104981
Bioorganic chemistry 2021 Aug;113:104981
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
Liu C, Hua H, Zhu H, Cheng Y, Guo Y, Yao W, Qian H
International journal of biological macromolecules 2021 Aug 31;185:804-812
International journal of biological macromolecules 2021 Aug 31;185:804-812
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl4-induced liver injury in vivo.
Xin C, Liu S, Qu H, Wang Z
International journal of biological macromolecules 2021 Aug 31;185:338-349
International journal of biological macromolecules 2021 Aug 31;185:338-349
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Zhao Y, Lu J, Mao A, Zhang R, Guan S
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease.
Yang X, Chen A, Liang Q, Dong Q, Fu M, Liu X, Wang S, Li Y, Ye Y, Lan Z, Ou JS, Lu L, Yan J
Free radical biology & medicine 2021 Aug 20;172:530-540
Free radical biology & medicine 2021 Aug 20;172:530-540
A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis.
Lu R, Jiang Y, Lai X, Liu S, Sun L, Zhou ZW
International journal of molecular sciences 2021 Aug 18;22(16)
International journal of molecular sciences 2021 Aug 18;22(16)
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Kato R, Ijiri Y, Hayashi T
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Hong J, Shi Z, Li C, Ji X, Li S, Chen Y, Jiang G, Shi M, Wang W, Zhang Y, Hu B, Yan S
Free radical biology & medicine 2021 Aug 1;171:365-378
Free radical biology & medicine 2021 Aug 1;171:365-378
Myricetin protects against H2 O2 -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Kan X, Liu J, Chen Y, Guo W, Xu D, Cheng J, Cao Y, Yang Z, Fu S
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Journal of dairy science 2021 Apr;104(4):4516-4528
Journal of dairy science 2021 Apr;104(4):4516-4528
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Wang Y, Wang HL, Xing GD, Qian Y, Zhong JF, Chen KL
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Zhang J, Jiang D, Lin S, Cheng Y, Pan J, Ding W, Chen Y, Fan J
Life sciences 2021 Apr 1;270:119131
Life sciences 2021 Apr 1;270:119131
Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation.
Wang K, Zheng X, Pan Z, Yao W, Gao X, Wang X, Ding X
Frontiers in cell and developmental biology 2020;8:559
Frontiers in cell and developmental biology 2020;8:559
Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells.
Chen S, Qin L, Wu X, Fu X, Lin S, Chen D, Xiao G, Shao Z, Cao H
Frontiers in cell and developmental biology 2020;8:127
Frontiers in cell and developmental biology 2020;8:127
Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system.
Jiao Z, Wu Y, Qu S
Cell death discovery 2020;6:78
Cell death discovery 2020;6:78
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-
Wu J, Yang CL, Sha YK, Wu Y, Liu ZY, Yuan ZH, Sun ZL
The American journal of Chinese medicine 2020;48(1):127-142
The American journal of Chinese medicine 2020;48(1):127-142
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
The Journal of toxicological sciences 2020;45(11):673-680
The Journal of toxicological sciences 2020;45(11):673-680
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
Zhu Q, Zeng J, Li J, Chen X, Miao J, Jin Q, Chen H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
Heme Oxygenase-1-Mediated Autophagy Protects against Oxidative Damage in Rat Nucleus Pulposus-Derived Mesenchymal Stem Cells.
Chen S, Liu S, Zhao L, Lin H, Ma K, Shao Z
Oxidative medicine and cellular longevity 2020;2020:9349762
Oxidative medicine and cellular longevity 2020;2020:9349762
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Meng X, Zhang C, Guo Y, Han Y, Wang C, Chu H, Kong L, Ma H
Oxidative medicine and cellular longevity 2020;2020:8787156
Oxidative medicine and cellular longevity 2020;2020:8787156
Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.
Li X, Zou Y, Xing J, Fu YY, Wang KY, Wan PZ, Zhai XY
Oxidative medicine and cellular longevity 2020;2020:6286984
Oxidative medicine and cellular longevity 2020;2020:6286984
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Tian TT, Li QR, Gan SQ, Chang CR, Shen XC
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.
Zavaczki E, Gáll T, Zarjou A, Hendrik Z, Potor L, Tóth CZ, Méhes G, Gyetvai Á, Agarwal A, Balla G, Balla J
Oxidative medicine and cellular longevity 2020;2020:3721383
Oxidative medicine and cellular longevity 2020;2020:3721383
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
Inhibition of Brd4 by JQ1 Promotes Functional Recovery From Spinal Cord Injury by Activating Autophagy.
Li Y, Xiang J, Zhang J, Lin J, Wu Y, Wang X
Frontiers in cellular neuroscience 2020;14:555591
Frontiers in cellular neuroscience 2020;14:555591
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.
Kong J, Wang J, Gong X, Zheng X, Chen T
Drug design, development and therapy 2020;14:5521-5533
Drug design, development and therapy 2020;14:5521-5533
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug design, development and therapy 2020;14:1971-1982
Drug design, development and therapy 2020;14:1971-1982
4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
Wei X, Wang H, Sun X, Huang X, Xu W, Liang Y, Liu L, Mo S, Lin X, Lin J
American journal of translational research 2020;12(5):2169-2180
American journal of translational research 2020;12(5):2169-2180
Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.
Chen Z, Zhang C, Ma H, Huang Z, Li J, Lou J, Li B, Tu Q, Gao W
Frontiers in pharmacology 2020;11:951
Frontiers in pharmacology 2020;11:951
Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway.
Zhao M, Tang X, Gong D, Xia P, Wang F, Xu S
Frontiers in pharmacology 2020;11:71
Frontiers in pharmacology 2020;11:71
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.
Deng HF, Yue LX, Wang NN, Zhou YQ, Zhou W, Liu X, Ni YH, Huang CS, Qiu LZ, Liu H, Tan HL, Tang XL, Wang YG, Ma ZC, Gao Y
Frontiers in pharmacology 2020;11:624529
Frontiers in pharmacology 2020;11:624529
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Qi D, Liu H, Sun X, Luo D, Zhu M, Tao T, Gao C, Zhou C, Zhou W, Xiao J
Frontiers in pharmacology 2020;11:621110
Frontiers in pharmacology 2020;11:621110
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Li B, Chen Z, Luo X, Zhang C, Chen H, Wang S, Zhao M, Ma H, Liu J, Cheng M, Yang Y, Yan H
Frontiers in pharmacology 2020;11:612932
Frontiers in pharmacology 2020;11:612932
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Hu J, Zhu Z, Ying H, Yao J, Ma H, Li L, Zhao Y
Frontiers in pharmacology 2020;11:605065
Frontiers in pharmacology 2020;11:605065
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Frontiers in pharmacology 2020;11:601716
Frontiers in pharmacology 2020;11:601716
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Chen S, Ding R, Hu Z, Yin X, Xiao F, Zhang W, Yan S, Lv C
Frontiers in immunology 2020;11:1829
Frontiers in immunology 2020;11:1829
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Wang J, Fang Z, Song C, Kang H, Guo Q, Dong Y, Zhang Y, Peng R, Guan H, Li F
Frontiers in pharmacology 2020;11:1175
Frontiers in pharmacology 2020;11:1175
Kaempferol Protects Blood Vessels From Damage Induced by Oxidative Stress and Inflammation in Association With the Nrf2/HO-1 Signaling Pathway.
Yao H, Sun J, Wei J, Zhang X, Chen B, Lin Y
Frontiers in pharmacology 2020;11:1118
Frontiers in pharmacology 2020;11:1118
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Li R, Xiao J, Tang S, Lin X, Xu H, Han B, Yang M, Liu F
Molecular medicine reports 2020 Sep;22(3):2545-2550
Molecular medicine reports 2020 Sep;22(3):2545-2550
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Kong H, Wang H, Zhuo Z, Li Z, Tian P, Wu J, Liu J, Chen Z, Zhang J, Luo Q
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway.
Nishikawa S, Inoue Y, Hori Y, Miyajima C, Morishita D, Ohoka N, Hida S, Makino T, Hayashi H
Antioxidants (Basel, Switzerland) 2020 Sep 9;9(9)
Antioxidants (Basel, Switzerland) 2020 Sep 9;9(9)
Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia reperfusion in mice.
Wang ZS, Zhou HH, Han Q, Guo YL, Li ZY
Acta cirurgica brasileira 2020 Sep 4;35(8):e202000802
Acta cirurgica brasileira 2020 Sep 4;35(8):e202000802
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Jiang TY, Pan YF, Wan ZH, Lin YK, Zhu B, Yuan ZG, Ma YH, Shi YY, Zeng TM, Dong LW, Tan YX, Wang HY
Science translational medicine 2020 Sep 23;12(562)
Science translational medicine 2020 Sep 23;12(562)
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Zhang B, Yu D, Luo N, Yang C, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way.
Zhao SJ, Liu H, Chen J, Qian DF, Kong FQ, Jie J, Yin GY, Li QQ, Fan J
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2020 Oct;35(10):2015-2031
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2020 Oct;35(10):2015-2031
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
Xiong Y, Xin DQ, Hu Q, Wang LX, Qiu J, Yuan HT, Chu XL, Liu DX, Li G, Wang Z
Neural regeneration research 2020 Oct;15(10):1920-1930
Neural regeneration research 2020 Oct;15(10):1920-1930
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D3 Plus Nicotine.
Liou SF, Nguyen TTN, Hsu JH, Sulistyowati E, Huang SE, Wu BN, Lin MC, Yeh JL
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Li Y, Wu J, Yu S, Zhu J, Zhou Y, Wang P, Li L, Zhao Y
Brain research 2020 Oct 15;1745:146948
Brain research 2020 Oct 15;1745:146948
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
Li M, Liu P, Xue Y, Liang Y, Shi J, Han X, Zhang J, Chu X, Chu L
Oncology reports 2020 Nov;44(5):2306-2316
Oncology reports 2020 Nov;44(5):2306-2316
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation.
Pan LL, Ren Z, Liu Y, Zhao Y, Li H, Pan X, Fang X, Liang W, Wang Y, Yang J, Sun J
Journal of cellular and molecular medicine 2020 Nov;24(22):12955-12969
Journal of cellular and molecular medicine 2020 Nov;24(22):12955-12969
Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo.
Xia Y, Liu S, Li C, Ai Z, Shen W, Ren W, Yang X
Cell death & disease 2020 Nov 17;11(11):988
Cell death & disease 2020 Nov 17;11(11):988
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Yang B, Xue Q, Guo J, Wang X, Zhang Y, Guo K, Li W, Chen S, Xue T, Qi X, Wang J
Autophagy 2020 May;16(5):842-861
Autophagy 2020 May;16(5):842-861
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway.
Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y
Biomolecules & therapeutics 2020 May 1;28(3):259-266
Biomolecules & therapeutics 2020 May 1;28(3):259-266
Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats.
Fang D, Lin Q, Wang C, Zheng C, Li Y, Huang T, Ni F, Wu Z, Chen B, Sun L
International immunopharmacology 2020 Mar;80:106151
International immunopharmacology 2020 Mar;80:106151
7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway.
Qu Z, Chen Y, Luo ZH, Shen XL, Hu YJ
The Journal of pharmacy and pharmacology 2020 Mar;72(3):385-395
The Journal of pharmacy and pharmacology 2020 Mar;72(3):385-395
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Cell proliferation 2020 Mar;53(3):e12779
Cell proliferation 2020 Mar;53(3):e12779
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Zhu M, Liu H, Sun K, Liu J, Mou Y, Qi D, Zhou C, Abudunaibi M, Tasiken B, Li J, Cheng H, Huang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Lin Z, Fu C, Yan Z, Wu Y, Zhan J, Lou Z, Liao X, Pan J
Food & function 2020 Mar 26;11(3):2654-2666
Food & function 2020 Mar 26;11(3):2654-2666
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Liu J, Tan Y, Yang B, Wu Y, Fan B, Zhu S, Song E, Song Y
Environment international 2020 Jun;139:105701
Environment international 2020 Jun;139:105701
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role.
Zhou D, Yang Q, Tian T, Chang Y, Li Y, Duan LR, Li H, Wang SW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110075
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110075
Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System.
Tanaka Y, Ito T, Tsuji G, Furue M
Antioxidants (Basel, Switzerland) 2020 Jun 9;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 9;9(6)
Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts.
Cao H, Yang L, Hou B, Sun D, Lin L, Song HL, Shen ZY
Stem cell research & therapy 2020 Jun 5;11(1):218
Stem cell research & therapy 2020 Jun 5;11(1):218
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Guo A, Li K, Xiao Q
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM2.5 from Beijing, China, in Winter.
Niu BY, Li WK, Li JS, Hong QH, Khodahemmati S, Gao JF, Zhou ZX
International journal of environmental research and public health 2020 Jul 6;17(13)
International journal of environmental research and public health 2020 Jul 6;17(13)
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Jasek-Gajda E, Jurkowska H, Jasińska M, Lis GJ
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
Bach1-induced suppression of angiogenesis is dependent on the BTB domain.
Jiang L, Jia M, Wei X, Guo J, Hao S, Mei A, Zhi X, Wang X, Li Q, Jin J, Zhang J, Li S, Meng D
EBioMedicine 2020 Jan;51:102617
EBioMedicine 2020 Jan;51:102617
Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upregulating the Nrf2/HO-1/CO Pathway to Inhibit Connexin 43 Expression.
Zhou L, Ao L, Yan Y, Li C, Li W, Ye A, Liu J, Hu Y, Fang W, Li Y
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jan;17(1):340-355
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jan;17(1):340-355
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Dong Y, Xing Y, Sun J, Sun W, Xu Y, Quan C
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, Chen Y, Wei Y, He X, Zhao J, Han H, Sun M, Xiao K
Cell death & disease 2020 Jan 2;11(1):6
Cell death & disease 2020 Jan 2;11(1):6
Polychlorinated biphenyl quinone promotes macrophage polarization to CD163+ cells through Nrf2 signaling pathway.
Liu J, Yang B, Wang Y, Wu Y, Fan B, Zhu S, Song E, Song Y
Environmental pollution (Barking, Essex : 1987) 2020 Feb;257:113587
Environmental pollution (Barking, Essex : 1987) 2020 Feb;257:113587
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8+CD28- T cells.
Yin N, Wu C, Qiu J, Zhang Y, Bo L, Xu Y, Shi M, Zhu S, Yang G, Mao C
Stem cell research & therapy 2020 Feb 4;11(1):49
Stem cell research & therapy 2020 Feb 4;11(1):49
H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron.
Mesquita G, Silva T, Gomes AC, Oliveira PF, Alves MG, Fernandes R, Almeida AA, Moreira AC, Gomes MS
Scientific reports 2020 Feb 20;10(1):3061
Scientific reports 2020 Feb 20;10(1):3061
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, Liu C, Tao T, Zhou C, Sun X, Guo F, Xiao J
Cell death & disease 2020 Feb 18;11(2):129
Cell death & disease 2020 Feb 18;11(2):129
Syringin protects against colitis by ameliorating inflammation.
Zhang H, Gu H, Jia Q, Zhao Y, Li H, Shen S, Liu X, Wang G, Shi Q
Archives of biochemistry and biophysics 2020 Feb 15;680:108242
Archives of biochemistry and biophysics 2020 Feb 15;680:108242
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Life sciences 2020 Feb 15;243:117244
Life sciences 2020 Feb 15;243:117244
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z
Life sciences 2020 Feb 1;242:117248
Life sciences 2020 Feb 1;242:117248
Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling.
Zhang P, Yin Y, Wang T, Li W, Li C, Zeng X, Yang W, Zhang R, Tang Y, Shi L, Li R, Tao K
Free radical biology & medicine 2020 Feb 1;147:23-36
Free radical biology & medicine 2020 Feb 1;147:23-36
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Zhang X, Feng J, Su S, Huang L
Pharmaceutical biology 2020 Dec;58(1):239-246
Pharmaceutical biology 2020 Dec;58(1):239-246
Silibinin ameliorats H2O2-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, Xu W, Wu K, Zhang Q, Liu Y, Wu J
Virulence 2020 Dec;11(1):537-553
Virulence 2020 Dec;11(1):537-553
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.
Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG
Aging 2020 Dec 29;12(24):24504-24521
Aging 2020 Dec 29;12(24):24504-24521
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Gu M, Jin J, Ren C, Chen X, Gao W, Wang X, Wu Y, Tian N, Pan Z, Wu A, Zhou Y, Zhang X
Food & function 2020 Dec 1;11(12):10852-10863
Food & function 2020 Dec 1;11(12):10852-10863
Brainstem iron overload and injury in a rat model of brainstem hemorrhage.
Guo X, Ma L, Li H, Qi X, Wei Y, Duan Z, Xu J, Wang C, You C, Tian M
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Aug;29(8):104956
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Aug;29(8):104956
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Du J, Zhu M, Li H, Liang G, Li Y, Feng S
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Xie D, Jiang L, Lin Y, Liu Z
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, Leng X
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y, Deng Y, Zhang G, Chen Z, Chen Y, Liu T
Cell death & disease 2020 Aug 18;11(8):641
Cell death & disease 2020 Aug 18;11(8):641
Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells.
Wang J, Zhang X, Zhang L, Yan T, Wu B, Xu F, Jia Y
European journal of pharmacology 2020 Aug 15;881:173236
European journal of pharmacology 2020 Aug 15;881:173236
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Huang K, Zhao X
Experimental cell research 2020 Aug 15;393(2):112100
Experimental cell research 2020 Aug 15;393(2):112100
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
Kuo PC, Weng WT, Scofield BA, Paraiso HC, Brown DA, Wang PY, Yu IC, Yen JH
Journal of neuroinflammation 2020 Apr 29;17(1):138
Journal of neuroinflammation 2020 Apr 29;17(1):138
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Apr 19;397:115014
Toxicology and applied pharmacology 2020 Apr 19;397:115014
Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.
Xian P, Hei Y, Wang R, Wang T, Yang J, Li J, Di Z, Liu Z, Baskys A, Liu W, Wu S, Long Q
Theranostics 2019;9(20):5956-5975
Theranostics 2019;9(20):5956-5975
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Sun X, Wang S, Gai J, Guan J, Li J, Li Y, Zhao J, Zhao C, Fu L, Li Q
Frontiers in oncology 2019;9:754
Frontiers in oncology 2019;9:754
Inhibition of Mitochondrial Complex I Aggravates Folic Acid-Induced Acute Kidney Injury.
Zhang W, Yang Y, Gao H, Zhang Y, Jia Z, Huang S
Kidney & blood pressure research 2019;44(5):1002-1013
Kidney & blood pressure research 2019;44(5):1002-1013
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681
Oxidative medicine and cellular longevity 2019;2019:8564681
CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Peng C, Zhou ZM, Li J, Luo Y, Zhou YS, Ke XH, Huang KE
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Zhao K, Li Y, Wang Z, Han N, Wang Y
BioMed research international 2019;2019:4348973
BioMed research international 2019;2019:4348973
Prevention of Huntington's Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress.
Liu P, Li Y, Yang W, Liu D, Ji X, Chi T, Guo Z, Li L, Zou L
Oxidative medicine and cellular longevity 2019;2019:4032428
Oxidative medicine and cellular longevity 2019;2019:4032428
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Zhang HF, Wang JH, Wang YL, Gao C, Gu YT, Huang J, Wang JH, Zhang Z
Oxidative medicine and cellular longevity 2019;2019:2853534
Oxidative medicine and cellular longevity 2019;2019:2853534
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, Ma H, Liang X, Liu X, Yang J, Wei J
Oxidative medicine and cellular longevity 2019;2019:2654910
Oxidative medicine and cellular longevity 2019;2019:2654910
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Liu Y, Zhang S, Xue J, Wei Z, Ao P, Shen B, Ding L
Oxidative medicine and cellular longevity 2019;2019:2053149
Oxidative medicine and cellular longevity 2019;2019:2053149
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress.
Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y
Drug design, development and therapy 2019;13:1461-1472
Drug design, development and therapy 2019;13:1461-1472
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
American journal of translational research 2019;11(1):379-392
American journal of translational research 2019;11(1):379-392
FGF10 Enhances Peripheral Nerve Regeneration via the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant Response.
Dong L, Li R, Li D, Wang B, Lu Y, Li P, Yu F, Jin Y, Ni X, Wu Y, Yang S, Lv G, Li X, Xiao J, Wang J
Frontiers in pharmacology 2019;10:1224
Frontiers in pharmacology 2019;10:1224
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
Li J, Bao G, ALyafeai E, Ding J, Li S, Sheng S, Shen Z, Jia Z, Lin C, Zhang C, Lou Z, Xu H, Gao W, Zhou K
Frontiers in pharmacology 2019;10:1017
Frontiers in pharmacology 2019;10:1017
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Zhang C, Zhan J, Zhao M, Dai H, Deng Y, Zhou W, Zhao L
Neurotoxicology 2019 Sep;74:74-80
Neurotoxicology 2019 Sep;74:74-80
Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation.
Zheng J, Tian X, Zhang W, Zheng P, Huang F, Ding G, Yang Z
Marine drugs 2019 Sep 27;17(10)
Marine drugs 2019 Sep 27;17(10)
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Jing L, Jiang JR, Liu DM, Sheng JW, Zhang WF, Li ZJ, Wei LY
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Liu C, Cui Y, Pi F, Guo Y, Cheng Y, Qian H
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
Liu X, Song Z, Bai J, Nauwynck H, Zhao Y, Jiang P
Veterinary research 2019 Sep 11;50(1):61
Veterinary research 2019 Sep 11;50(1):61
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Gao W, Wang W, Zhang J, Deng P, Hu J, Yang J, Deng Z
Metabolic brain disease 2019 Oct;34(5):1267-1280
Metabolic brain disease 2019 Oct;34(5):1267-1280
Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways.
Han CY, Sun TT, Xv GP, Wang SS, Gu JG, Liu CY
Molecular medicine reports 2019 Oct;20(4):3095-3102
Molecular medicine reports 2019 Oct;20(4):3095-3102
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Xie YK, Zhou X, Yuan HT, Qiu J, Xin DQ, Chu XL, Wang DC, Wang Z
Neural regeneration research 2019 Oct;14(10):1734-1742
Neural regeneration research 2019 Oct;14(10):1734-1742
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Lu Q, Tan S, Gu W, Li F, Hua W, Zhang S, Chen F, Tang L
Journal of ethnopharmacology 2019 Oct 28;243:112089
Journal of ethnopharmacology 2019 Oct 28;243:112089
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Yang HM, Li SZ
Brain sciences 2019 Oct 12;9(10)
Brain sciences 2019 Oct 12;9(10)
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
Yao B, He J, Yin X, Shi Y, Wan J, Tian Z
Toxicology letters 2019 Nov;316:109-118
Toxicology letters 2019 Nov;316:109-118
Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity.
Li S, Jiang X, Luo Y, Zhou B, Shi M, Liu F, Sha A
Chemosphere 2019 Nov;234:579-588
Chemosphere 2019 Nov;234:579-588
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
Sun K, Luo J, Jing X, Guo J, Yao X, Hao X, Ye Y, Liang S, Lin J, Wang G, Guo F
Aging 2019 Nov 26;11(22):10513-10531
Aging 2019 Nov 26;11(22):10513-10531
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, Li J, Deng X, Shui X, Gao W, Ding J, Xiao J, Xu H
Cell death & disease 2019 Nov 18;10(12):872
Cell death & disease 2019 Nov 18;10(12):872
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Liao Z, Zhang J, Wang J, Yan T, Xu F, Wu B, Xiao F, Bi K, Niu J, Jia Y
International journal of biological macromolecules 2019 Nov 1;140:568-576
International journal of biological macromolecules 2019 Nov 1;140:568-576
Predictable chronic mild stress promotes recovery from LPS-induced depression.
Dang R, Guo YY, Zhang K, Jiang P, Zhao MG
Molecular brain 2019 May 3;12(1):42
Molecular brain 2019 May 3;12(1):42
Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.
Liao Z, Zhang J, Liu B, Yan T, Xu F, Xiao F, Wu B, Bi K, Jia Y
Molecules (Basel, Switzerland) 2019 May 17;24(10)
Molecules (Basel, Switzerland) 2019 May 17;24(10)
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Wang H, Wei W, Lan X, Liu N, Li Y, Ma H, Sun T, Peng X, Zhuang C, Yu J
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
Zhong L, Hao H, Chen D, Hou Q, Zhu Z, He W, Sun S, Sun M, Li M, Fu X
Journal of cellular physiology 2019 Mar;234(3):2606-2617
Journal of cellular physiology 2019 Mar;234(3):2606-2617
The harmful effects of acute PM2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs.
Dong L, Sun W, Li F, Shi M, Meng X, Wang C, Meng M, Tang W, Liu H, Wang L, Song L
Scientific reports 2019 Mar 5;9(1):3495
Scientific reports 2019 Mar 5;9(1):3495
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, Ke P, Zhuang J, Huang X
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, Qiao H, Li L, Yang J, Yu S, Zhao L, Wang S, Liu HM, Suo Z, Zhao W
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.
Wang P, Zhao Y, Li Y, Wu J, Yu S, Zhu J, Li L, Zhao Y
Neuroscience 2019 Jul 1;410:140-149
Neuroscience 2019 Jul 1;410:140-149
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Shan H, Li T, Zhang L, Yang R, Li Y, Zhang M, Dong Y, Zhou Y, Xu C, Yang B, Liang H, Gao X, Shan H
EBioMedicine 2019 Jan;39:59-68
EBioMedicine 2019 Jan;39:59-68
14-3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling.
Song J, Zhang X, Liao Z, Liang H, Chu L, Dong W, Zhang X, Ge Q, Liu Q, Fan P, Zhang Z, Zhang B
Journal of experimental & clinical cancer research : CR 2019 Jan 3;38(1):3
Journal of experimental & clinical cancer research : CR 2019 Jan 3;38(1):3
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Huang J, Lu Y, Zhang B, Yang S, Zhang Q, Cui H, Lu X, Zhao Y, Yang X, Li R
Toxicology 2019 Jan 15;412:29-36
Toxicology 2019 Jan 15;412:29-36
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks.
Wang J, Konishi T
Cancer science 2019 Feb;110(2):686-696
Cancer science 2019 Feb;110(2):686-696
Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms.
Li X, Zhang Q, Hou N, Li J, Liu M, Peng S, Zhang Y, Luo Y, Zhao B, Wang S, Zhang Y, Qiao Y
International journal of molecular sciences 2019 Feb 18;20(4)
International journal of molecular sciences 2019 Feb 18;20(4)
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
Li L, Liu T, Liu L, Li S, Zhang Z, Zhang R, Zhou Y, Liu F
Journal of bioenergetics and biomembranes 2019 Dec;51(6):393-402
Journal of bioenergetics and biomembranes 2019 Dec;51(6):393-402
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
Dietary Dihydroartemisinin Supplementation Attenuates Hepatic Oxidative Damage of Weaned Piglets with Intrauterine Growth Retardation through the Nrf2/ARE Signaling Pathway.
Zhao Y, Niu Y, He J, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2019 Dec 13;9(12)
Animals : an open access journal from MDPI 2019 Dec 13;9(12)
Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.
Kang Y, Li Y, Zhang T, Chi Y, Liu M
International journal of molecular medicine 2019 Aug;44(2):447-456
International journal of molecular medicine 2019 Aug;44(2):447-456
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
Deferoxamine Alleviates Iron Overload and Brain Injury in a Rat Model of Brainstem Hemorrhage.
Guo X, Qi X, Li H, Duan Z, Wei Y, Zhang F, Tian M, Ma L, You C
World neurosurgery 2019 Aug;128:e895-e904
World neurosurgery 2019 Aug;128:e895-e904
NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.
Peng D, Lu H, Zhu S, Zhou Z, Hu T, Chen Z, Zaika A, El-Rifai W
Cancer letters 2019 Aug 28;458:46-55
Cancer letters 2019 Aug 28;458:46-55
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway.
Luo Q, Li Y, Huang C, Cheng D, Ma W, Xia Y, Liu W, Chen Z
Molecules (Basel, Switzerland) 2019 Aug 15;24(16)
Molecules (Basel, Switzerland) 2019 Aug 15;24(16)
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
Ochratoxin A causes mitochondrial dysfunction, apoptotic and autophagic cell death and also induces mitochondrial biogenesis in human gastric epithelium cells.
Li Q, Dong Z, Lian W, Cui J, Wang J, Shen H, Liu W, Yang J, Zhang X, Cui H
Archives of toxicology 2019 Apr;93(4):1141-1155
Archives of toxicology 2019 Apr;93(4):1141-1155
Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells.
Gáll T, Pethő D, Nagy A, Hendrik Z, Méhes G, Potor L, Gram M, Åkerström B, Smith A, Nagy P, Balla G, Balla J
Frontiers in physiology 2018;9:1595
Frontiers in physiology 2018;9:1595
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
Frontiers in pharmacology 2018;9:1178
Frontiers in pharmacology 2018;9:1178
Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.
Potor L, Nagy P, Méhes G, Hendrik Z, Jeney V, Pethő D, Vasas A, Pálinkás Z, Balogh E, Gyetvai Á, Whiteman M, Torregrossa R, Wood ME, Olvasztó S, Nagy P, Balla G, Balla J
Oxidative medicine and cellular longevity 2018;2018:3812568
Oxidative medicine and cellular longevity 2018;2018:3812568
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, Li X, Xie C, Zhong C, Fu S
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Wang K, Lv Q, Miao YM, Qiao SM, Dai Y, Wei ZF
Biochemical pharmacology 2018 Sep;155:494-509
Biochemical pharmacology 2018 Sep;155:494-509
Liver injury induced in Balb/c mice by PM2.5 exposure and its alleviation by compound essential oils.
Ya P, Xu H, Ma Y, Fang M, Yan X, Zhou J, Li F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:590-598
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:590-598
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Cyclooxygenase‑2‑mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium‑tritium fusion radiation.
Yang X, Liu H, Jiang X, Jin C, Xu Z, Li T, Wang Z, Wang J
International journal of molecular medicine 2018 Oct;42(4):1945-1954
International journal of molecular medicine 2018 Oct;42(4):1945-1954
Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells.
Yang J, Chen Z, Liu N, Chen Y
Redox biology 2018 Oct;19:158-165
Redox biology 2018 Oct;19:158-165
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
Wu C, Yang L, Tucker D, Dong Y, Zhu L, Duan R, Liu TC, Zhang Q
Medicine and science in sports and exercise 2018 May;50(5):945-956
Medicine and science in sports and exercise 2018 May;50(5):945-956
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.
Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R
Toxicology and applied pharmacology 2018 May 1;346:28-36
Toxicology and applied pharmacology 2018 May 1;346:28-36
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Paraiso HC, Kuo PC, Curfman ET, Moon HJ, Sweazey RD, Yen JH, Chang FL, Yu IC
Journal of neuroinflammation 2018 Mar 29;15(1):100
Journal of neuroinflammation 2018 Mar 29;15(1):100
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J
Redox biology 2018 Jun;16:189-198
Redox biology 2018 Jun;16:189-198
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Zhang J, Tucker LD, DongYan, Lu Y, Yang L, Wu C, Li Y, Zhang Q
Neurochemistry international 2018 Jun;116:1-12
Neurochemistry international 2018 Jun;116:1-12
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.
Muliaditan T, Caron J, Okesola M, Opzoomer JW, Kosti P, Georgouli M, Gordon P, Lall S, Kuzeva DM, Pedro L, Shields JD, Gillett CE, Diebold SS, Sanz-Moreno V, Ng T, Hoste E, Arnold JN
Nature communications 2018 Jul 27;9(1):2951
Nature communications 2018 Jul 27;9(1):2951
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, Liu Z, Guo Z, Chen X, He P, Li Z, Li F, Jiang J, Liu P, Li Z
Aging 2018 Jul 24;10(7):1722-1744
Aging 2018 Jul 24;10(7):1722-1744
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T
Molecular neurobiology 2018 Jan;55(1):421-434
Molecular neurobiology 2018 Jan;55(1):421-434
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Lin EY, Bayarsengee U, Wang CC, Chiang YH, Cheng CW
Environmental toxicology 2018 Jan;33(1):72-82
Environmental toxicology 2018 Jan;33(1):72-82
Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88's effects on the gut microbiota.
Xiao HW, Li Y, Luo D, Dong JL, Zhou LX, Zhao SY, Zheng QS, Wang HC, Cui M, Fan SJ
Experimental & molecular medicine 2018 Jan 26;50(1):e433
Experimental & molecular medicine 2018 Jan 26;50(1):e433
Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2.
Hou Y, Peng S, Li X, Yao J, Xu J, Fang J
ACS chemical neuroscience 2018 Dec 19;9(12):3108-3116
ACS chemical neuroscience 2018 Dec 19;9(12):3108-3116
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
Li ST, Dai Q, Zhang SX, Liu YJ, Yu QQ, Tan F, Lu SH, Wang Q, Chen JW, Huang HQ, Liu PQ, Li M
Acta pharmacologica Sinica 2018 Aug;39(8):1294-1304
Acta pharmacologica Sinica 2018 Aug;39(8):1294-1304
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Zhang X, Wang Y, Velkov T, Tang S, Dai C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
Du L, Lei Y, Chen J, Song H, Wu X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1359-1368
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1359-1368
α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.
Lv C, Maharjan S, Wang Q, Sun Y, Han X, Wang S, Mao Z, Xin Y, Zhang B
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1273-1287
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1273-1287
Non-Lethal Sonodynamic Therapy Inhibits Atherosclerotic Plaque Progression in ApoE-/- Mice and Attenuates ox-LDL-mediated Macrophage Impairment by Inducing Heme Oxygenase-1.
Wang Y, Wang W, Xu H, Sun Y, Sun J, Jiang Y, Yao J, Tian Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(6):2432-2446
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(6):2432-2446
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Li L, Kong L, Song H
Experimental and therapeutic medicine 2017 Sep;14(3):2505-2510
Experimental and therapeutic medicine 2017 Sep;14(3):2505-2510
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
Duan L, Li J, Ma P, Yang X, Xu S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):47-56
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):47-56
Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice.
Niu L, Shao M, Liu Y, Hu J, Li R, Xie H, Zhou L, Shi L, Zhang R, Niu Y
Chemico-biological interactions 2017 Sep 25;275:133-144
Chemico-biological interactions 2017 Sep 25;275:133-144
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: Role of oxidative stress and endoplasmic reticulum stress.
Liu S, Xin D, Wang L, Zhang T, Bai X, Li T, Xie Y, Xue H, Bo S, Liu D, Wang Z
Redox biology 2017 Oct;13:528-540
Redox biology 2017 Oct;13:528-540
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Li D, Dai C, Yang X, Wang F, Yu X, Xiao X, Tang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Establishment and characterization of human osteosarcoma cells resistant to pyropheophorbide-α methyl ester-mediated photodynamic therapy.
Tao Y, Ou Y, Yin H, Chen Y, Zhong S, Gao Y, Zhao Z, He B, Huang Q, Deng Q
International journal of oncology 2017 Nov;51(5):1427-1438
International journal of oncology 2017 Nov;51(5):1427-1438
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Kuo PC, Yu IC, Scofield BA, Brown DA, Curfman ET, Paraiso HC, Chang FL, Yen JH
Brain, behavior, and immunity 2017 May;62:180-192
Brain, behavior, and immunity 2017 May;62:180-192
Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
Liu C, Hao Y, Yin F, Zhang Y, Liu J
Cell biology international 2017 May;41(5):544-554
Cell biology international 2017 May;41(5):544-554
Role of the cystathionine β-synthase/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system.
Jia H, Ye J, You J, Shi X, Kang W, Wang T
Oncology reports 2017 May;37(5):3001-3009
Oncology reports 2017 May;37(5):3001-3009
Effect of ozone oxidative preconditioning on oxidative stress injury in a rat model of kidney transplantation.
Qiu T, Wang ZS, Liu XH, Chen H, Zhou JQ, Chen ZY, Wang M, Jiang GJ, Wang L, Yu G, Zhang L, Shen Y, Zhang L, He L, Wang HX, Zhang WJ
Experimental and therapeutic medicine 2017 May;13(5):1948-1955
Experimental and therapeutic medicine 2017 May;13(5):1948-1955
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis.
Lu J, Guo S, Xue X, Chen Q, Ge J, Zhuo Y, Zhong H, Chen B, Zhao M, Han W, Suzuki T, Zhu M, Xia L, Schneider C, Blackwell TS, Porter NA, Zheng L, Tsimikas S, Yin H
The Journal of biological chemistry 2017 Mar 31;292(13):5378-5391
The Journal of biological chemistry 2017 Mar 31;292(13):5378-5391
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Gao M, Zhao B, Chen M, Liu Y, Xu M, Wang Z, Liu S, Zhang C
Biomaterials 2017 Jun;130:14-27
Biomaterials 2017 Jun;130:14-27
Global Transcriptomic Profiling of Cortex and Striatum: Cerebral Injury after Ischemia/Reperfusion in a Mouse Model.
Zhao Z, Lu Z, Sun X, Zhao T, Zhang J, Zhou C, Zheng X, Zhang H, Shi G
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Jul;26(7):1622-1634
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Jul;26(7):1622-1634
The electrophilic character of quinones is essential for the suppression of Bach1.
Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y
Toxicology 2017 Jul 15;387:17-26
Toxicology 2017 Jul 15;387:17-26
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Shen S, Li J, You H, Wu Z, Wu Y, Zhao Y, Zhu Y, Guo Q, Li X, Li R, Ma P, Yang X, Chen M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Heme-oxygenase-1 Production by Intestinal CX3CR1+ Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis.
Marelli G, Erreni M, Anselmo A, Taverniti V, Guglielmetti S, Mantovani A, Allavena P
Cancer research 2017 Aug 15;77(16):4472-4485
Cancer research 2017 Aug 15;77(16):4472-4485
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Yang D, Xiao CX, Su ZH, Huang MW, Qin M, Wu WJ, Jia WW, Zhu YZ, Hu JF, Liu XH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Zhang C, Li C, Chen S, Li Z, Jia X, Wang K, Bao J, Liang Y, Wang X, Chen M, Li P, Su H, Wan JB, Lee SMY, Liu K, He C
Redox biology 2017 Apr;11:1-11
Redox biology 2017 Apr;11:1-11
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Nie H, Xue X, Liu G, Guan G, Liu H, Sun L, Zhao L, Wang X, Chen Z
Free radical research 2016;50(11):1200-1213
Free radical research 2016;50(11):1200-1213
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
Hou CL, Wang MJ, Sun C, Huang Y, Jin S, Mu XP, Chen Y, Zhu YC
Oxidative medicine and cellular longevity 2016;2016:7570489
Oxidative medicine and cellular longevity 2016;2016:7570489
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway.
Li W, Ma F, Zhang L, Huang Y, Li X, Zhang A, Hou C, Zhu Y, Zhu Y
Oxidative medicine and cellular longevity 2016;2016:4690857
Oxidative medicine and cellular longevity 2016;2016:4690857
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C
PloS one 2016;11(2):e0149032
PloS one 2016;11(2):e0149032
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
Hu Q, Li T, Wang L, Xie Y, Liu S, Bai X, Zhang T, Bo S, Xin D, Xue H, Li G, Wang Z
Frontiers in cellular neuroscience 2016;10:306
Frontiers in cellular neuroscience 2016;10:306
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
Lu L, Dong J, Li D, Zhang J, Fan S
Free radical biology & medicine 2016 Oct;99:463-471
Free radical biology & medicine 2016 Oct;99:463-471
3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis.
Kuo PC, Brown DA, Scofield BA, Yu IC, Chang FL, Wang PY, Yen JH
Brain, behavior, and immunity 2016 Oct;57:173-186
Brain, behavior, and immunity 2016 Oct;57:173-186
Desferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1.
Kang H, Yan Y, Jia P, Yang K, Guo C, Chen H, Qi J, Qian N, Xu X, Wang F, Li C, Guo L, Deng L
Cell death & disease 2016 Oct 27;7(10):e2435
Cell death & disease 2016 Oct 27;7(10):e2435
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Chen K, Li J, Li S, Feng J, Wu L, Liu T, Zhang R, Xu S, Cheng K, Zhou Y, Zhou S, Wang F, Dai W, Xia Y, Lu J, Zhou Y, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
Yu G, Deng A, Tang W, Ma J, Yuan C, Ma J
Neurochemistry international 2016 Jun;96:113-20
Neurochemistry international 2016 Jun;96:113-20
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
High expression of heme oxygenase-1 in target organs may attenuate acute graft-versus-host disease through regulation of immune balance of TH17/Treg.
Yu M, Wang J, Fang Q, Liu P, Chen S, Zhe N, Lin X, Zhang Y, Zhao J, Zhou Z
Transplant immunology 2016 Jul;37:10-17
Transplant immunology 2016 Jul;37:10-17
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, Peng J
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats.
Li H, He H, Wang Z, Cai J, Sun B, Wu Q, Zhang Y, Zhou G, Yang L
Gene 2016 Jul 10;585(2):256-64
Gene 2016 Jul 10;585(2):256-64
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
Su C, Shi Q, Song X, Fu J, Liu Z, Wang Y, Wang Y, Xia X, Song E, Song Y
Toxicology 2016 Jul 1;363-364:48-57
Toxicology 2016 Jul 1;363-364:48-57
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
Zhu Y, Li J, Wu Z, Lu Y, You H, Li R, Li B, Yang X, Duan L
Toxicology research 2016 Jan 1;5(1):268-277
Toxicology research 2016 Jan 1;5(1):268-277
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Deng S, Tang S, Dai C, Zhou Y, Yang X, Li D, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.
Hu B, Shi C, Xu C, Cao P, Tian Y, Zhang Y, Deng L, Chen H, Yuan W
Scientific reports 2016 Feb 15;6:21190
Scientific reports 2016 Feb 15;6:21190
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
Zhang W, Li Y, Ding H, Du Y, Wang L
Renal failure 2016 Aug;38(7):1099-106
Renal failure 2016 Aug;38(7):1099-106
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Zhou ZY, Ren LW, Zhan P, Yang HY, Chai DD, Yu ZW
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell.
Chen N, Wu L, Yuan H, Wang J
International journal of biological sciences 2015;11(7):833-44
International journal of biological sciences 2015;11(7):833-44
Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo.
Shi Z, Niu Y, Wang Q, Shi L, Guo H, Liu Y, Zhu Y, Liu S, Liu C, Chen X, Zhang R
Journal of hazardous materials 2015 Nov 15;298:310-9
Journal of hazardous materials 2015 Nov 15;298:310-9
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Yang R, Zhang M, Gustafson AR, Wang E, Cole MP, Tooley CE, Cheng A
Bioscience reports 2015 May 1;35(3)
Bioscience reports 2015 May 1;35(3)
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, Chen H, Lu B, Sun Z, Wu S, Yang S, Li X, Ye X, Song E, Song Y
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Su C, Zhang P, Song X, Shi Q, Fu J, Xia X, Bai H, Hu L, Xu D, Song E, Song Y
Chemical research in toxicology 2015 Apr 20;28(4):765-74
Chemical research in toxicology 2015 Apr 20;28(4):765-74
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S
International journal of clinical and experimental pathology 2014;7(6):2780-9
International journal of clinical and experimental pathology 2014;7(6):2780-9
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Xu D, Hu L, Su C, Xia X, Zhang P, Fu J, Wang W, Xu D, Du H, Hu Q, Song E, Song Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Heme oxygenase-1 silencing increases the sensitivity of human osteosarcoma MG63 cells to arsenic trioxide.
Zhong L, Wang Y, Li W, Gu J, Li X, Wang X, Yue Z, Mu Y, Bai J, Li R, Zhang H
Molecular and cellular biochemistry 2014 Jul;392(1-2):135-44
Molecular and cellular biochemistry 2014 Jul;392(1-2):135-44
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response.
Pan LL, Liu XH, Shen YQ, Wang NZ, Xu J, Wu D, Xiong QH, Deng HY, Huang GY, Zhu YZ
International journal of cardiology 2013 Oct 9;168(4):3770-8
International journal of cardiology 2013 Oct 9;168(4):3770-8
Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection.
Silva-Gomes S, Appelberg R, Larsen R, Soares MP, Gomes MS
Infection and immunity 2013 Jul;81(7):2536-45
Infection and immunity 2013 Jul;81(7):2536-45
Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.
He HJ, Wang GY, Gao Y, Ling WH, Yu ZW, Jin TR
World journal of diabetes 2012 May 15;3(5):94-104
World journal of diabetes 2012 May 15;3(5):94-104
Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways.
Liu XH, Pan LL, Yang HB, Gong QH, Zhu YZ
European journal of pharmacology 2012 Apr 5;680(1-3):108-14
European journal of pharmacology 2012 Apr 5;680(1-3):108-14
Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium.
Song G, Cui Y, Zhong N, Han J
Journal of clinical pathology 2009 Sep;62(9):802-7
Journal of clinical pathology 2009 Sep;62(9):802-7
Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC.
Chen N, Sun W, Deng X, Hao Y, Chen X, Xing B, Jia W, Ma J, Wei H, Zhu Y, Qian X, Jiang Y, He F
Proteomics 2008 Dec;8(23-24):5108-18
Proteomics 2008 Dec;8(23-24):5108-18
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 10701-1-AP(HMOX1 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HMOX1 (IP:10701-1-AP, 3ug; Detection:10701-1-AP 1:1000) with HeLa cells lysate 3000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 10701-1-AP(HMOX1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HMOX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HMOX1. This antibody recognizes human, mouse, rat antigen. The HMOX1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.