18042-1-AP

antibody from Proteintech Group

Targeting: CCNY C10orf9, CBCP1, CFP1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Supportive data in Antibodypedia)

Antibody Data

Product number

18042-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#18042-1-AP, RRID:AB_2074004

Product name

CCNY antibody

Antibody type

Polyclonal

Description

KD/KO validated CCNY antibody (Cat. #18042-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis.

Molinas A, Heil S, Koch S
Cells 2021 Sep 6;10(9)

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Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway.

Hwang H, Hur YN, Sohn H, Seo J, Hong JH, Cho E, Choi Y, Lee S, Song S, Lee AR, Kim S, Jo DG, Rhim H, Park M
Progress in neurobiology 2021 Mar;198:101915

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Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.

Hwang H, Seo J, Choi Y, Cho E, Sohn H, Jang J, Lee AR, Lee J, Kim S, Koh HY, Park M
Pharmacological research 2020 Oct;160:105100

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Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.

Chen L, Wang X, Cheng H, Zhang W, Liu Y, Zeng W, Yu L, Huang C, Liu G
Biochemical and biophysical research communications 2020 Dec 17;533(4):1162-1169

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Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex.

Hernández-Ortega S, Sánchez-Botet A, Quandt E, Masip N, Gasa L, Verde G, Jiménez J, Levin RS, Rutaganira FU, Burlingame AL, Wolfgeher D, Ribeiro MPC, Kron SJ, Shokat KM, Clotet J
Experimental & molecular medicine 2019 Apr 16;51(4):1-17

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Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons.

Joe IS, Kim JH, Kim H, Hong JH, Kim M, Park M
PloS one 2017;12(2):e0172547

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Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.

Wang X, Jia Y, Fei C, Song X, Li L
The Journal of biological chemistry 2016 Dec 16;291(51):26427-26434

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Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.

Cho E, Kim DH, Hur YN, Whitcomb DJ, Regan P, Hong JH, Kim H, Ho Suh Y, Cho K, Park M
Scientific reports 2015 Jul 29;5:12624

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Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.

Shehata SN, Deak M, Morrice NA, Ohta E, Hunter RW, Kalscheuer VM, Sakamoto K
The Biochemical journal 2015 Aug 1;469(3):409-20

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Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.

Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K
Cellular signalling 2012 Nov;24(11):2085-94

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

K-562 cells were subjected to SDS PAGE followed by western blot with 18042-1-AP(CCNY antibody) at dilution of 1:600

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using CCNY antibody 18042-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunoprecipitation

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

IP Result of anti-CCNY (IP:18042-1-AP, 3ug; Detection:18042-1-AP 1:600) with K-562 cells lysate 2400ug.

Sample type

cell line