19851-1-AP
antibody from Proteintech Group
Targeting: STING1
ERIS, FLJ38577, MITA, MPYS, NET23, STING, TMEM173
Antibody data
- Antibody Data
- Antigen structure
- References [79]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 19851-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19851-1-AP, RRID:AB_10665370
- Product name
- TMEM173/STING antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TMEM173/STING antibody (Cat. #19851-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The cGAS-STING pathway connects mitochondrial damage to inflammation in burn-induced acute lung injury in rat.
Molecular cloning and functional analysis of Macaca mulatta STING.
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production.
STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis.
Activation of the cGAS-STING signaling pathway in adenomyosis patients.
Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.
Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function.
STING-mediated inflammation contributes to Gao binge ethanol feeding model.
Screening of Porcine Innate Immune Adaptor Signaling Revealed Several Anti-PRRSV Signaling Pathways.
eccDNAs are apoptotic products with high innate immunostimulatory activity.
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Sustained IL-4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848.
Pharmacological activation of STING blocks SARS-CoV-2 infection.
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine.
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells.
A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation.
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes.
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Transfected DNA is targeted by STING-mediated restriction.
Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction.
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Long non-coding RNA MALAT1 targeting STING transcription promotes bronchopulmonary dysplasia through regulation of CREB.
Reactive oxygen species oxidize STING and suppress interferon production.
Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells.
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages.
Redox homeostasis maintained by GPX4 facilitates STING activation.
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo.
Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation.
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.
Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer.
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.
African Swine Fever Virus Armenia/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway.
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes.
IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
A proteomics landscape of circadian clock in mouse liver.
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
TRIM29 promotes DNA virus infections by inhibiting innate immune response.
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity.
MITA modulated autophagy flux promotes cell death in breast cancer cells.
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
Activation of STING requires palmitoylation at the Golgi.
Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.
NET23/STING promotes chromatin compaction from the nuclear envelope.
Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-κB induced cell death.
Comish PB, Liu MM, Huebinger R, Carlson D, Kang R, Tang D
Burns : journal of the International Society for Burn Injuries 2022 Feb;48(1):168-175
Burns : journal of the International Society for Burn Injuries 2022 Feb;48(1):168-175
Molecular cloning and functional analysis of Macaca mulatta STING.
Zhao M, Zhang H, Sha H, Li H, Wang R
Developmental and comparative immunology 2022 Feb;127:104296
Developmental and comparative immunology 2022 Feb;127:104296
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Yang B, Zhang G, Qin X, Huang Y, Ren X, Sun J, Ma S, Liu Y, Song D, Liu Y, Cui Y, Wang H, Wang J
Frontiers in immunology 2021;12:730483
Frontiers in immunology 2021;12:730483
Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production.
Li R, Liu W, Yin X, Zheng F, Wang Z, Wu X, Zhang X, Du Q, Huang Y, Tong D
Frontiers in microbiology 2021;12:702881
Frontiers in microbiology 2021;12:702881
STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis.
Liu ZZ, Yang YJ, Zhou CK, Yan SQ, Ma K, Gao Y, Chen W
Frontiers in immunology 2021;12:636861
Frontiers in immunology 2021;12:636861
Activation of the cGAS-STING signaling pathway in adenomyosis patients.
Lin Y, Wang L, Ye M, Yu KN, Sun X, Xue M, Deng X
Immunity, inflammation and disease 2021 Sep;9(3):932-942
Immunity, inflammation and disease 2021 Sep;9(3):932-942
Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.
Li TF, Xu HZ, Xu YH, Yu TT, Tang JM, Li K, Wang C, Peng XC, Li QR, Sang XY, Zheng MY, Liu Y, Zhao L, Chen X
Molecular pharmaceutics 2021 Sep 6;18(9):3601-3615
Molecular pharmaceutics 2021 Sep 6;18(9):3601-3615
Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
Yuan SJ, Wang C, Xu HZ, Liu Y, Zheng MY, Li K, Sun SK, Komatsu N, Zhao L, Chen X
International journal of pharmaceutics 2021 Sep 5;606:120872
International journal of pharmaceutics 2021 Sep 5;606:120872
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
Chen A, Yang F, Kuang J, Xiong Y, Mi BB, Zhou Y, Hu JJ, Song SJ, Wan T, Wan ZZ, Huang HY, Li XR, Song W, Qiu WX
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function.
Xu Y, Zhang Y, Sun S, Luo J, Jiang S, Zhang J, Liu X, Shao Q, Cao Q, Zheng W, Chen N, Meurens F, Zhu J
Viruses 2021 Sep 14;13(9)
Viruses 2021 Sep 14;13(9)
STING-mediated inflammation contributes to Gao binge ethanol feeding model.
Wang L, You HM, Meng HW, Pan XY, Chen X, Bi YH, Zhang YF, Li JJ, Yin NN, Zhang ZW, Huang C, Li J
Journal of cellular physiology 2021 Oct 26;
Journal of cellular physiology 2021 Oct 26;
Screening of Porcine Innate Immune Adaptor Signaling Revealed Several Anti-PRRSV Signaling Pathways.
Xu Y, Ye M, Zhang Y, Sun S, Luo J, Jiang S, Zhang J, Liu X, Shao Q, Cao Q, Zheng W, Meurens F, Chen N, Zhu J
Vaccines 2021 Oct 14;9(10)
Vaccines 2021 Oct 14;9(10)
eccDNAs are apoptotic products with high innate immunostimulatory activity.
Wang Y, Wang M, Djekidel MN, Chen H, Liu D, Alt FW, Zhang Y
Nature 2021 Nov;599(7884):308-314
Nature 2021 Nov;599(7884):308-314
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
Liu W, Reyes HM, Yang JF, Li Y, Stewart KM, Basil MC, Lin SM, Katzen J, Morrisey EE, Weiss SR, You J
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Hou J, Han L, Zhao Z, Liu H, Zhang L, Ma C, Yi F, Liu B, Zheng Y, Gao C
Nature communications 2021 May 20;12(1):2970
Nature communications 2021 May 20;12(1):2970
Sustained IL-4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848.
Banete A, Gee K, Basta S
Journal of leukocyte biology 2021 May 19;
Journal of leukocyte biology 2021 May 19;
Pharmacological activation of STING blocks SARS-CoV-2 infection.
Li M, Ferretti M, Ying B, Descamps H, Lee E, Dittmar M, Lee JS, Whig K, Kamalia B, Dohnalová L, Uhr G, Zarkoob H, Chen YC, Ramage H, Ferrer M, Lynch K, Schultz DC, Thaiss CA, Diamond MS, Cherry S
Science immunology 2021 May 18;6(59)
Science immunology 2021 May 18;6(59)
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Ma D, Yang M, Wang Q, Sun C, Shi H, Jing W, Bi Y, Shen X, Ma X, Qin Z, Lin Y, Zhu L, Zhao Y, Cheng Y, Han L
Science advances 2021 Mar;7(13)
Science advances 2021 Mar;7(13)
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Zhou Y, Zhao S, Gao X, Jiang S, Ma J, Wang R, Li Q, Qin L, Tong Z, Wu J, Zhao J
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine.
Mai J, Li Z, Xia X, Zhang J, Li J, Liu H, Shen J, Ramirez M, Li F, Li Z, Yokoi K, Liu X, Mittendorf EA, Ferrari M, Shen H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jun;8(12):2100166
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jun;8(12):2100166
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells.
Vasiyani H, Shinde A, Roy M, Mane M, Singh K, Singh J, Gohel D, Currim F, Vaidya K, Chhabria M, Singh R
Apoptosis : an international journal on programmed cell death 2021 Jun;26(5-6):293-306
Apoptosis : an international journal on programmed cell death 2021 Jun;26(5-6):293-306
A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation.
Takahashi K, Niki T, Ogawa E, Fumika K, Nishioka Y, Sawa M, Arai H, Mukai K, Taguchi T
Scientific reports 2021 Jun 7;11(1):11996
Scientific reports 2021 Jun 7;11(1):11996
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stühler K, Stork B
Scientific reports 2021 Jul 5;11(1):13863
Scientific reports 2021 Jul 5;11(1):13863
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Experimental eye research 2021 Jan;202:108366
Experimental eye research 2021 Jan;202:108366
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Sun H, Huang Y, Mei S, Xu F, Liu X, Zhao F, Yin L, Zhang D, Wei L, Wu C, Ma S, Wang J, Cen S, Liang C, Hu S, Guo F
Cell reports 2021 Jan 5;34(1):108586
Cell reports 2021 Jan 5;34(1):108586
Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes.
Nakamura K, Ishii Y, Takasu S, Nohmi T, Shibutani M, Ogawa K
Archives of toxicology 2021 Aug;95(8):2851-2865
Archives of toxicology 2021 Aug;95(8):2851-2865
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N
Nature 2021 Aug;596(7873):570-575
Nature 2021 Aug;596(7873):570-575
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.
Zhao M, Wang B, Zhang C, Su Z, Guo B, Zhao Y, Zheng R
Cell death and differentiation 2021 Aug;28(8):2517-2535
Cell death and differentiation 2021 Aug;28(8):2517-2535
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Zhao F, Zheng T, Gong W, Wu J, Xie H, Li W, Zhang R, Liu P, Liu J, Wu X, Zhao Y, Ren J
Cell death & disease 2021 Aug 27;12(9):815
Cell death & disease 2021 Aug 27;12(9):815
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2021 Aug 12;:1-17
Autophagy 2021 Aug 12;:1-17
Transfected DNA is targeted by STING-mediated restriction.
Gu C, Ming L, Tao S, Luo M, Guo H, Xie Y, Liu J, Shen Z
Biochemical and biophysical research communications 2021 Apr 16;549:207-213
Biochemical and biophysical research communications 2021 Apr 16;549:207-213
Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
Ghosh M, Saha S, Bettke J, Nagar R, Parrales A, Iwakuma T, van der Velden AWM, Martinez LA
Cancer cell 2021 Apr 12;39(4):494-508.e5
Cancer cell 2021 Apr 12;39(4):494-508.e5
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction.
Gong W, Lu L, Zhou Y, Liu J, Ma H, Fu L, Huang S, Zhang Y, Zhang A, Jia Z
American journal of physiology. Renal physiology 2021 Apr 1;320(4):F608-F616
American journal of physiology. Renal physiology 2021 Apr 1;320(4):F608-F616
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Ren D, Qin G, Zhao J, Sun Y, Zhang B, Li D, Wang B, Jin X, Wu H
American journal of cancer research 2020;10(9):2851-2864
American journal of cancer research 2020;10(9):2851-2864
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Li W, Luo Z, Yan CY, Wang XH, He ZJ, Ouyang SH, Yan C, Liu LF, Zhou QQ, Mu HL, Gong HB, Duan WJ, Liang L, Kurihara H, Feng D, Li YF, He RR
Theranostics 2020;10(20):9032-9049
Theranostics 2020;10(20):9032-9049
Long non-coding RNA MALAT1 targeting STING transcription promotes bronchopulmonary dysplasia through regulation of CREB.
Chen JH, Feng DD, Chen YF, Yang CX, Juan CX, Cao Q, Chen X, Liu S, Zhou GP
Journal of cellular and molecular medicine 2020 Sep;24(18):10478-10492
Journal of cellular and molecular medicine 2020 Sep;24(18):10478-10492
Reactive oxygen species oxidize STING and suppress interferon production.
Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, Reese TA
eLife 2020 Sep 4;9
eLife 2020 Sep 4;9
Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells.
Guo Y, Gu R, Gan D, Hu F, Li G, Xu G
Cell communication and signaling : CCS 2020 Oct 28;18(1):172
Cell communication and signaling : CCS 2020 Oct 28;18(1):172
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.
McKnight KL, Swanson KV, Austgen K, Richards C, Mitchell JK, McGivern DR, Fritch E, Johnson J, Remlinger K, Magid-Slav M, Kapustina M, You S, Lemon SM
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27598-27607
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27598-27607
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
Peng Y, Zhuang J, Ying G, Zeng H, Zhou H, Cao Y, Chen H, Xu C, Fu X, Xu H, Li J, Cao S, Chen J, Gu C, Yan F, Chen G
Journal of neuroinflammation 2020 May 25;17(1):165
Journal of neuroinflammation 2020 May 25;17(1):165
RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
Yang B, Liu Y, Cui Y, Song D, Zhang G, Ma S, Liu Y, Chen M, Chen F, Wang H, Wang J
PLoS pathogens 2020 Mar;16(3):e1008387
PLoS pathogens 2020 Mar;16(3):e1008387
SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages.
Joshi JC, Joshi B, Rochford I, Rayees S, Akhter MZ, Baweja S, Chava KR, Tauseef M, Abdelkarim H, Natarajan V, Gaponenko V, Mehta D
Cell reports 2020 Mar 24;30(12):4096-4109.e5
Cell reports 2020 Mar 24;30(12):4096-4109.e5
Redox homeostasis maintained by GPX4 facilitates STING activation.
Jia M, Qin D, Zhao C, Chai L, Yu Z, Wang W, Tong L, Lv L, Wang Y, Rehwinkel J, Yu J, Zhao W
Nature immunology 2020 Jul;21(7):727-735
Nature immunology 2020 Jul;21(7):727-735
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo.
Yamashiro LH, Wilson SC, Morrison HM, Karalis V, Chung JJ, Chen KJ, Bateup HS, Szpara ML, Lee AY, Cox JS, Vance RE
Nature communications 2020 Jul 7;11(1):3382
Nature communications 2020 Jul 7;11(1):3382
Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation.
Zhang CX, Huang DJ, Baloche V, Zhang L, Xu JX, Li BW, Zhao XR, He J, Mai HQ, Chen QY, Zhang XS, Busson P, Cui J, Li J
Oncogenesis 2020 Jul 6;9(7):65
Oncogenesis 2020 Jul 6;9(7):65
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N
Nature immunology 2020 Feb;21(2):158-167
Nature immunology 2020 Feb;21(2):158-167
TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.
Nozawa T, Sano S, Minowa-Nozawa A, Toh H, Nakajima S, Murase K, Aikawa C, Nakagawa I
Nature communications 2020 Feb 7;11(1):770
Nature communications 2020 Feb 7;11(1):770
Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer.
Yu J, Deng H, Xu Z
Scientific reports 2020 Dec 7;10(1):21360
Scientific reports 2020 Dec 7;10(1):21360
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Zhang X, Wu J, Liu Q, Li X, Li S, Chen J, Hong Z, Wu X, Zhao Y, Ren J
Cell death & disease 2020 Dec 11;11(12):1050
Cell death & disease 2020 Dec 11;11(12):1050
DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.
Chen W, Yu SX, Zhou FH, Zhang XJ, Gao WY, Li KY, Liu ZZ, Han WY, Yang YJ
Frontiers in immunology 2019;10:474
Frontiers in immunology 2019;10:474
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.
Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R
Cell reports 2019 Oct 29;29(5):1261-1273.e6
Cell reports 2019 Oct 29;29(5):1261-1273.e6
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
Zhang CX, Ye SB, Ni JJ, Cai TT, Liu YN, Huang DJ, Mai HQ, Chen QY, He J, Zhang XS, Zeng YX, Li J, Cui J
Cell death and differentiation 2019 Nov;26(11):2314-2328
Cell death and differentiation 2019 Nov;26(11):2314-2328
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F
Science signaling 2019 Nov 26;12(609)
Science signaling 2019 Nov 26;12(609)
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Gui X, Yang H, Li T, Tan X, Shi P, Li M, Du F, Chen ZJ
Nature 2019 Mar;567(7747):262-266
Nature 2019 Mar;567(7747):262-266
Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.
Li L, Yang L, Cheng S, Fan Z, Shen Z, Xue W, Zheng Y, Li F, Wang D, Zhang K, Lian J, Wang D, Zhu Z, Zhao J, Zhang Y
Molecular cancer 2019 Jun 20;18(1):108
Molecular cancer 2019 Jun 20;18(1):108
African Swine Fever Virus Armenia/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway.
García-Belmonte R, Pérez-Núñez D, Pittau M, Richt JA, Revilla Y
Journal of virology 2019 Jun 15;93(12)
Journal of virology 2019 Jun 15;93(12)
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE
Science (New York, N.Y.) 2019 Jul 5;365(6448)
Science (New York, N.Y.) 2019 Jul 5;365(6448)
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
Li Q, Liu C, Yue R, El-Ashram S, Wang J, He X, Zhao D, Zhou X, Xu L
International journal of molecular sciences 2019 Feb 19;20(4)
International journal of molecular sciences 2019 Feb 19;20(4)
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
Ye L, Zhang Q, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D, Zhong B
PLoS pathogens 2019 Apr;15(4):e1007680
PLoS pathogens 2019 Apr;15(4):e1007680
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Cao Q, Juan CX, Zhang DQ, He J, Cao YZ, Pasha AB, Wang JY, Qi HX, Li S, Jin R, Zhou GP
Experimental cell research 2018 Sep 15;370(2):498-505
Experimental cell research 2018 Sep 15;370(2):498-505
Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes.
Verrier ER, Yim SA, Heydmann L, El Saghire H, Bach C, Turon-Lagot V, Mailly L, Durand SC, Lucifora J, Durantel D, Pessaux P, Manel N, Hirsch I, Zeisel MB, Pochet N, Schuster C, Baumert TF
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1695-1709
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1695-1709
IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.
Yang B, Song D, Liu Y, Cui Y, Lu G, Di W, Xing H, Ma L, Guo Z, Guan Y, Wang H, Wang J
FEBS letters 2018 May;592(10):1693-1704
FEBS letters 2018 May;592(10):1693-1704
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.
Motani K, Kosako H
The Journal of biological chemistry 2018 May 18;293(20):7717-7726
The Journal of biological chemistry 2018 May 18;293(20):7717-7726
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Torralba D, Baixauli F, Villarroya-Beltri C, Fernández-Delgado I, Latorre-Pellicer A, Acín-Pérez R, Martín-Cófreces NB, Jaso-Tamame ÁL, Iborra S, Jorge I, González-Aseguinolaza G, Garaude J, Vicente-Manzanares M, Enríquez JA, Mittelbrunn M, Sánchez-Madrid F
Nature communications 2018 Jul 9;9(1):2658
Nature communications 2018 Jul 9;9(1):2658
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
Liu Y, Liu Y, Wu J, Roizman B, Zhou GG
Proceedings of the National Academy of Sciences of the United States of America 2018 Apr 3;115(14):E3230-E3237
Proceedings of the National Academy of Sciences of the United States of America 2018 Apr 3;115(14):E3230-E3237
A proteomics landscape of circadian clock in mouse liver.
Wang Y, Song L, Liu M, Ge R, Zhou Q, Liu W, Li R, Qie J, Zhen B, Wang Y, He F, Qin J, Ding C
Nature communications 2018 Apr 19;9(1):1553
Nature communications 2018 Apr 19;9(1):1553
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, Saitoh T
Cell reports 2017 Sep 19;20(12):2944-2954
Cell reports 2017 Sep 19;20(12):2944-2954
TRIM29 promotes DNA virus infections by inhibiting innate immune response.
Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z
Nature communications 2017 Oct 16;8(1):945
Nature communications 2017 Oct 16;8(1):945
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
Wang J, Kang L, Song D, Liu L, Yang S, Ma L, Guo Z, Ding H, Wang H, Yang B
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482
HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity.
Wang J, Yang S, Liu L, Wang H, Yang B
Virus research 2017 Mar 15;232:13-21
Virus research 2017 Mar 15;232:13-21
MITA modulated autophagy flux promotes cell death in breast cancer cells.
Bhatelia K, Singh K, Prajapati P, Sripada L, Roy M, Singh R
Cellular signalling 2017 Jul;35:73-83
Cellular signalling 2017 Jul;35:73-83
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Song S, Peng P, Tang Z, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, Zhang M, Zhang J, Wu H, Li C, Wang X, Wang H, Ruan Y, Gu J
Scientific reports 2017 Feb 8;7:39858
Scientific reports 2017 Feb 8;7:39858
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
Jie C, Luo Z, Chen H, Wang M, Yan C, Mao ZF, Xiao GK, Kurihara H, Li YF, He RR
Oncotarget 2017 Dec 1;8(62):105615-105629
Oncotarget 2017 Dec 1;8(62):105615-105629
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
Liu Y, Qu L, Liu Y, Roizman B, Zhou GG
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 15;114(33):E6902-E6911
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 15;114(33):E6902-E6911
Activation of STING requires palmitoylation at the Golgi.
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, Barber GN, Arai H, Taguchi T
Nature communications 2016 Jun 21;7:11932
Nature communications 2016 Jun 21;7:11932
Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.
Liu Y, Li J, Chen J, Li Y, Wang W, Du X, Song W, Zhang W, Lin L, Yuan Z
Journal of virology 2015 Feb;89(4):2287-300
Journal of virology 2015 Feb;89(4):2287-300
NET23/STING promotes chromatin compaction from the nuclear envelope.
Malik P, Zuleger N, de las Heras JI, Saiz-Ros N, Makarov AA, Lazou V, Meinke P, Waterfall M, Kelly DA, Schirmer EC
PloS one 2014;9(11):e111851
PloS one 2014;9(11):e111851
Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-κB induced cell death.
Bhatelia K, Singh A, Tomar D, Singh K, Sripada L, Chagtoo M, Prajapati P, Singh R, Godbole MM, Singh R
Biochimica et biophysica acta 2014 Feb;1842(2):144-53
Biochimica et biophysica acta 2014 Feb;1842(2):144-53
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 19851-1-AP(TMEM173 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 19851-1-AP(TMEM173 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 19851-1-AP(TMEM173 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TMEM173 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TMEM173. This antibody recognizes human, mouse, rat antigen. The TMEM173 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.