ABIN2451994

antibody from antibodies-online

Targeting: HBEGF DTR, DTS, HEGFL

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

ABIN2451994

Provider

antibodies-online

Product name

anti-Heparin-Binding EGF-Like Growth Factor (HBEGF) (EGF Like Domain) antibody (Biotin)

Antibody type

Monoclonal

Antigen

Recombinant human HB-EGF ectodomain expressed in SF21 cell

Description

Purified

Reactivity

Human

Host

Mouse

Conjugate

Biotin

Epitope

EGF Like Domain

Isotype

IgG

Antibody clone number

4G10

Vial size

50 μg

Storage

-20 C (For long term storage: -80 C)

References

Submitted references

Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy.

Miyamoto S, Hirata M, Yamazaki A, Kageyama T, Hasuwa H, Mizushima H, Tanaka Y, Yagi H, Sonoda K, Kai M, Kanoh H, Nakano H, Mekada E
Cancer research 2004 Aug 15;64(16):5720-7

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EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF.

Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A
Nature 1999 Dec 23-30;402(6764):884-8

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Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.

Iwamoto R, Higashiyama S, Mitamura T, Taniguchi N, Klagsbrun M, Mekada E
The EMBO journal 1994 May 15;13(10):2322-30

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A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.

Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M
Science (New York, N.Y.) 1991 Feb 22;251(4996):936-9