320901

antibody from BioLegend
Targeting: MICB PERB11.2
Provider product page for 320901
Immunoprecipitation
Immunohistochemistry
Flow cytometry

Antibody data

Product number
320901 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#320901, RRID:AB_493190
Product name
Purified anti-human MICA/MICB
Antibody type
Monoclonal
Antigen
MICA/MICB
Description
6D4 antibody reacts with a common epitope of the human nonclassical MHC class I chain-related protein A (MICA) and B (MICB), also known as PERB11.1 and PERB11.2. The MIC gene is located in MHC class I region. MICA/B are 65-75 kD stress-inducible glycoproteins with highly polymorphic. They are MHC class I-like transmembrane molecules that do not associate β2-microglobulin and do not present peptides. MICA and MICB share 85% identify, and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells, fibroblasts, and IFN-α-stimulated dendritic cells. MIC molecules bind NKG2D, an activating receptor, and induce activation of NK cells, and subset of CD8+ α/β T cells and γ/δ T cells, as well as suppression of T cell proliferation. MICA/B recognition is involved in the regulation of tumor surveillance, viral infection and autoimmune diseases. The 6D4 antibody is able to block MIC mediated cytotoxicity.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
MICB protein structure - 320901 shown in red.