Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 21445-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- DDRGK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DDRGK1 antibody (Cat. #21445-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.
A pathogenic UFSP2 variant in an autosomal recessive form of pediatric neurodevelopmental anomalies and epilepsy.
Ufmylation regulates granulosa cell apoptosis via ER stress but not oxidative stress during goat follicular atresia.
Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination.
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.
UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis.
UFMylation is associated with LPS-induced inflammatory response in goat endometrial epithelial cells.
Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.
Proteomic and Biochemical Analyses Reveal a Novel Mechanism for Promoting Protein Ubiquitination and Degradation by UFBP1, a Key Component of Ufmylation.
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability.
Chen F, Sheng L, Xu C, Li J, Ali I, Li H, Cai Y
Frontiers in cell and developmental biology 2021;9:676789
Frontiers in cell and developmental biology 2021;9:676789
A pathogenic UFSP2 variant in an autosomal recessive form of pediatric neurodevelopmental anomalies and epilepsy.
Ni M, Afroze B, Xing C, Pan C, Shao Y, Cai L, Cantarel BL, Pei J, Grishin NV, Hewson S, Knight D, Mahida S, Michel D, Tarnopolsky M, Poduri A, Rotenberg A, Sondheimer N, DeBerardinis RJ
Genetics in medicine : official journal of the American College of Medical Genetics 2021 May;23(5):900-908
Genetics in medicine : official journal of the American College of Medical Genetics 2021 May;23(5):900-908
Ufmylation regulates granulosa cell apoptosis via ER stress but not oxidative stress during goat follicular atresia.
Zhang X, Yu T, Guo X, Zhang R, Jia Y, Shang C, Wang A, Jin Y, Lin P
Theriogenology 2021 Jul 15;169:47-55
Theriogenology 2021 Jul 15;169:47-55
Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
Quintero M, Liu S, Xia Y, Huang Y, Zou Y, Li G, Hu L, Singh N, Blumberg R, Cai Y, Xu H, Li H
Cell death & disease 2021 Jan 27;12(1):131
Cell death & disease 2021 Jan 27;12(1):131
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
Cao Y, Li R, Shen M, Li C, Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H, Cai Y
Cell death & disease 2021 Apr 20;12(5):416
Cell death & disease 2021 Apr 20;12(5):416
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination.
Liu J, Guan D, Dong M, Yang J, Wei H, Liang Q, Song L, Xu L, Bai J, Liu C, Mao J, Zhang Q, Zhou J, Wu X, Wang M, Cong YS
Nature cell biology 2020 Sep;22(9):1056-1063
Nature cell biology 2020 Sep;22(9):1056-1063
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.
Liang JR, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, Olzmann JA, Corn JE
Cell 2020 Mar 19;180(6):1160-1177.e20
Cell 2020 Mar 19;180(6):1160-1177.e20
UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis.
Wang L, Xu Y, Rogers H, Saidi L, Noguchi CT, Li H, Yewdell JW, Guydosh NR, Ye Y
Cell research 2020 Jan;30(1):5-20
Cell research 2020 Jan;30(1):5-20
UFMylation is associated with LPS-induced inflammatory response in goat endometrial epithelial cells.
Xiao J, Liu S, Yu T, Zhang R, Guo X, Jia Y, Shang C, Wang A, Jin Y, Lin P
Reproduction in domestic animals = Zuchthygiene 2020 Dec;55(12):1725-1734
Reproduction in domestic animals = Zuchthygiene 2020 Dec;55(12):1725-1734
Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.
Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole CJ, Lu C, Zhu H, Islam B, Riggelen JV, Browning D, Liu K, Blumberg R, Singh N, Li H
Cell discovery 2019;5:7
Cell discovery 2019;5:7
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina SK, Patel N, Savage NM, Sharma A, Kaufman RJ, Li H, Singh N
Nature communications 2019 Mar 6;10(1):1084
Nature communications 2019 Mar 6;10(1):1084
Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.
Lin JX, Xie XS, Weng XF, Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM
World journal of gastroenterology 2018 Sep 14;24(34):3898-3907
World journal of gastroenterology 2018 Sep 14;24(34):3898-3907
Proteomic and Biochemical Analyses Reveal a Novel Mechanism for Promoting Protein Ubiquitination and Degradation by UFBP1, a Key Component of Ufmylation.
Zhu Y, Lei Q, Li D, Zhang Y, Jiang X, Hu Z, Xu G
Journal of proteome research 2018 Apr 6;17(4):1509-1520
Journal of proteome research 2018 Apr 6;17(4):1509-1520
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability.
Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, Chen H, Wang M, Ju Z, Cong YS
Nature communications 2017 Jan 27;8:14186
Nature communications 2017 Jan 27;8:14186
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The DDRGK1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DDRGK1. This antibody recognizes human, mouse antigen. The DDRGK1 antibody has been validated for the following applications: ELISA, WB analysis.