Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 11334-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11334-1-AP, RRID:AB_10642566
- Product name
- PTP1B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PTP1B antibody (Cat. #11334-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ursonic acid from medicinal herbs inhibits PRRSV replication through activation of the innate immune response by targeting the phosphatase PTPN1.
Upregulation of PTPN1 aggravates endotoxemia-induced cardiac dysfunction through inhibiting mitophagy.
Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.
Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation.
Curcumin inhibits proliferation of hepatocellular carcinoma cells by blocking PTPN1 and PTPN11 expression.
Efficacy of Young Cinnamomum zeylanicum Blume Bark on Hyperglycemia and PTPase Activity in Type 2 Diabetes.
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
A Theranostic Small-Molecule Prodrug Conjugate for Neuroendocrine Prostate Cancer.
Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway.
BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.
GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner.
Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.
Multi-omics analyses of tumor-associated immune-infiltrating cells with the novel immune checkpoint protein tyrosine phosphatase 1B (PTP1B) in extracellular matrix of brain-lower-grade-glioma (LGG) and uveal-melanoma (UVM).
MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion.
Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance.
Endotoxin tolerance induced by Porphyromonas gingivalis lipopolysaccharide alters macrophage polarization.
Protein tyrosine phosphatase 1B regulates fibroblasts proliferation, motility and extracellular matrix synthesis via the MAPK/ERK signalling pathway in keloid.
PLXDC2 enhances invadopodium formation to promote invasion and metastasis of gastric cancer cells via interacting with PTP1B.
Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation.
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis.
The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.
Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma.
Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo.
Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p.
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
PTP1B promotes macrophage activation by regulating the NF-κB pathway in alcoholic liver injury.
Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells.
Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR.
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
HDAC6 interacts with PTPN1 to enhance melanoma cells progression.
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Yang Y, Gao Y, Sun H, Bai J, Zhang J, Zhang L, Liu X, Sun Y, Jiang P
Veterinary research 2024 May 23;55(1):67
Veterinary research 2024 May 23;55(1):67
Upregulation of PTPN1 aggravates endotoxemia-induced cardiac dysfunction through inhibiting mitophagy.
Song Q, Ma H, Zhu L, Qi Z, Lan Z, Liu K, Zhang H, Wang K, Wang N
International immunopharmacology 2024 Jan 5;126:111315
International immunopharmacology 2024 Jan 5;126:111315
Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.
Zhao Y, Liu Y, Deng J, Zhu C, Ma X, Jiang M, Fan D
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14263-14275
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14263-14275
Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.
Zhang ZH, Zhou XM, Zhang X
Brain sciences 2023 May 18;13(5)
Brain sciences 2023 May 18;13(5)
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation.
Fu J, Yu L, Yu Q, Yu N, Xu F, Li S
Journal of ginseng research 2023 Mar;47(2):274-282
Journal of ginseng research 2023 Mar;47(2):274-282
Curcumin inhibits proliferation of hepatocellular carcinoma cells by blocking PTPN1 and PTPN11 expression.
Zhang J, Liu Y, Wang X, Wang Z, Xing E, Li J, Wang D
Oncology letters 2023 Jul;26(1):307
Oncology letters 2023 Jul;26(1):307
Efficacy of Young Cinnamomum zeylanicum Blume Bark on Hyperglycemia and PTPase Activity in Type 2 Diabetes.
Mandal A, Sharma SK, Yadav SRM, Mirza AA, Thakur MS, Jachak S, Saini S, Roy P, Kant R, Patil M
Cureus 2023 Feb;15(2):e35023
Cureus 2023 Feb;15(2):e35023
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
Liu Y, Xu Q, Deng F, Zheng Z, Luo J, Wang P, Zhou J, Lu X, Zhang L, Chen Z, Zhang Q, Chen Q, Zuo D
Journal of experimental & clinical cancer research : CR 2023 Feb 1;42(1):38
Journal of experimental & clinical cancer research : CR 2023 Feb 1;42(1):38
A Theranostic Small-Molecule Prodrug Conjugate for Neuroendocrine Prostate Cancer.
Gonzalez P, Debnath S, Chen YA, Hernandez E, Jha P, Dakanali M, Hsieh JT, Sun X
Pharmaceutics 2023 Feb 1;15(2)
Pharmaceutics 2023 Feb 1;15(2)
Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway.
Wang AH, Ma HY, Yi YL, Zhu SJ, Yu ZW, Zhu J, Mei S, Bahetibike S, Lu YQ, Huang LT, Yang RY, Rui-Wang, Xiao SL, Qi R
European journal of pharmacology 2023 Dec 5;960:176116
European journal of pharmacology 2023 Dec 5;960:176116
BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.
Jin J, He Y, Guo J, Pan Q, Wei X, Xu C, Qi Z, Li Q, Ma S, Lin J, Jiang N, Ma J, Wang X, Jiang L, Ding Q, Osto E, Zhi X, Meng D
Nature communications 2023 Dec 21;14(1):8428
Nature communications 2023 Dec 21;14(1):8428
GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner.
Mi S, Zhang J, Sun M, Huo X, Lv Y, Beier F, Lu S, Yan J
Experimental cell research 2023 Dec 15;433(2):113824
Experimental cell research 2023 Dec 15;433(2):113824
Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.
Gao X, Wu Y, Chick JM, Abbott A, Jiang B, Wang DJ, Comte-Walters S, Johnson RH, Oberholtzer N, Nishimura MI, Gygi SP, Mehta A, Guttridge DC, Ball L, Mehrotra S, Sicinski P, Yu XZ, Wang H
Cell reports 2023 Apr 25;42(4):112314
Cell reports 2023 Apr 25;42(4):112314
Multi-omics analyses of tumor-associated immune-infiltrating cells with the novel immune checkpoint protein tyrosine phosphatase 1B (PTP1B) in extracellular matrix of brain-lower-grade-glioma (LGG) and uveal-melanoma (UVM).
Bai KH, Zhu MJ, Zhang YY, Li XP, Chen SL, Wang DW, Dai YJ
Frontiers in immunology 2022;13:1053856
Frontiers in immunology 2022;13:1053856
MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion.
Lu Y, Zhang X, Li X, Deng L, Wei C, Yang D, Tan X, Pan W, Pang L
Reproductive biology and endocrinology : RB&E 2022 May 24;20(1):82
Reproductive biology and endocrinology : RB&E 2022 May 24;20(1):82
Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance.
Wang Y, Xiong J, Yuan Y, Peng C, Wu P, Wang Y, Lu J, Yin Y, Xu J, Chen S, Liu J
Obesity (Silver Spring, Md.) 2022 Mar;30(3):680-693
Obesity (Silver Spring, Md.) 2022 Mar;30(3):680-693
Endotoxin tolerance induced by Porphyromonas gingivalis lipopolysaccharide alters macrophage polarization.
Gu JY, Fu ZB, Jia-Lu Chen, Liu YJ, Cao XZ, Sun Y
Microbial pathogenesis 2022 Mar;164:105448
Microbial pathogenesis 2022 Mar;164:105448
Protein tyrosine phosphatase 1B regulates fibroblasts proliferation, motility and extracellular matrix synthesis via the MAPK/ERK signalling pathway in keloid.
Qian L, Wang Q, Wei C, Wang L, Yang Y, Deng X, Liu J, Qi F
Experimental dermatology 2022 Feb;31(2):202-213
Experimental dermatology 2022 Feb;31(2):202-213
PLXDC2 enhances invadopodium formation to promote invasion and metastasis of gastric cancer cells via interacting with PTP1B.
Wu B, Wang YX, Wang JJ, Xiang DF, Zhang MS, Yan ZX, Wang WY, Miao JY, Lan X, Liu JJ, Li ZY, Li C, Fan JY, Liu JY, Jiang L, Xu SL, Cui YH, Qian F
Clinical & experimental metastasis 2022 Aug;39(4):691-710
Clinical & experimental metastasis 2022 Aug;39(4):691-710
Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation.
Wu J, Xue X, Fan G, Gu Y, Zhou F, Zheng Q, Liu R, Li Y, Ma B, Li S, Huang G, Ma L, Li X
Frontiers in pharmacology 2021;12:754976
Frontiers in pharmacology 2021;12:754976
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis.
Takaoka S, Yanagiya A, Mohamed HMA, Higa R, Abe T, Inoue KI, Takahashi A, Stoney P, Yamamoto T
iScience 2021 Oct 22;24(10):103151
iScience 2021 Oct 22;24(10):103151
The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.
Huang T, Li X, Wang F, Lu L, Hou W, Zhu M, Miao C
Cell death & disease 2021 Mar 29;12(4):333
Cell death & disease 2021 Mar 29;12(4):333
Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma.
Du J, Dong Z, Tan L, Tan M, Zhang F, Zhang K, Pan G, Li C, Shi S, Zhang Y, Liu Y, Cui H
Frontiers in cell and developmental biology 2020;8:607757
Frontiers in cell and developmental biology 2020;8:607757
Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo.
Feng CW, Chen NF, Chan TF, Chen WF
Parkinson's disease 2020;2020:8814236
Parkinson's disease 2020;2020:8814236
Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p.
Yao QP, Liu Z, Yao AH, Liu JT, Jiang J, Chen Y, Li SS, Han Y, Jiang ZL, Qi YX
Journal of cellular physiology 2020 Oct;235(10):6831-6842
Journal of cellular physiology 2020 Oct;235(10):6831-6842
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Chen Y, Tang J, Lu T, Liu F
Thoracic cancer 2020 Jul;11(7):1848-1860
Thoracic cancer 2020 Jul;11(7):1848-1860
PTP1B promotes macrophage activation by regulating the NF-κB pathway in alcoholic liver injury.
Yang L, Sun YY, Liu YR, Yin NN, Bu FT, Yu HX, Du XS, Li J, Huang C
Toxicology letters 2020 Feb 1;319:11-21
Toxicology letters 2020 Feb 1;319:11-21
Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells.
Shi C, Yang J, Hu L, Liao B, Qiao L, Shen W, Xie F, Zhu G
Aging 2020 Aug 3;12(15):15546-15555
Aging 2020 Aug 3;12(15):15546-15555
Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR.
Yang P, Zeng H, Tan W, Luo X, Zheng E, Zhao L, Wei L, Ruan XZ, Chen Y, Chen Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5658-5672
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5658-5672
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
Li C, Luo J, Guo S, Jia X, Guo C, Li X, Xu Q, Shi D
Molecular pharmaceutics 2019 May 6;16(5):1839-1850
Molecular pharmaceutics 2019 May 6;16(5):1839-1850
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N
Cells 2019 May 31;8(6)
Cells 2019 May 31;8(6)
HDAC6 interacts with PTPN1 to enhance melanoma cells progression.
Liu J, Luan W, Zhang Y, Gu J, Shi Y, Yang Y, Feng Z, Qi F
Biochemical and biophysical research communications 2018 Jan 22;495(4):2630-2636
Biochemical and biophysical research communications 2018 Jan 22;495(4):2630-2636
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Xiang M, Su H, Hong Z, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11334-1-AP(PTPN1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PTP1B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PTP1B. This antibody recognizes human,mouse,rat antigen. The PTP1B antibody has been validated for the following applications: ELISA, WB, IHC analysis.