BS8350

antibody from Bioworld Technology, Inc
Targeting: OSMR OSMRB, OSMRbeta
Provider product page for BS8350
Western blot
Immunohistochemistry

Antibody data

Product number
BS8350 - Provider product page
Provider
Bioworld Technology, Inc
Product name
OSMR polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human OSMR.
Description
Oncostatin M (OSM) is a glycoprotein that inhibits the growth of a broad range of human tumor cell lines, but does not influence the growth of normal human fibroblasts. Expression of OSM is greatest in activated monocytic and lymphocytic cell lines and in normal adherent macrophages. Amino acid sequence analysis of OSM has revealed homology with leukemia inhibitory factor (LIF), granulocyte colony stimulating factor (G-CSF) and interleukin 6 (IL-6), all of which affect the growth and differentiation of a broad range of cell types, including those of hematopoietic origin. OSMRÉÇ(oncostatin M receptorÉÇ), also known as OSMR, is a 979 amino acid single-pass type I membrane protein that functions as a receptor for OSM. Expressed at high levels in neural cells, as well as fibroblast and epithelial tumor lines, OSMRÉÇexists as a heterodimer that interacts with interleukins and is able to transduce OSM-induced signaling events. Defects in the gene encoding OSMRÉÇare the cause of primary cutaneous amyloidosis (PCA), an autosomal dominant disorder characterized by chronic itching of the skin.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
OSMR protein structure - BS8350 shown in red.