Tissue expression
Cell line expression
Protein structure
GSKIP
GSK3B interacting proteinC14orf129
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Top validated antibodies |
|||||
Invitrogen Antibodies | ![]() |
Monoclonal |
|
||
Abnova Corporation | ![]() |
Monoclonal |
|
||
Novus Biologicals | ![]() |
Monoclonal |
|
||
Atlas Antibodies | ![]() |
Polyclonal |
|
||
antibodies-online | ![]() |
Polyclonal |
|