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Western blot
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF284 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal Common gamma Chain/IL-2 R gamma Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human Common gamma Chain/IL-2 R gamma in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse IL-2 R gamma is observed, less than 10% cross-reactivity with recombinant human (rh) IL-2 R beta is observed, and less than 2% cross-reactivity with rhIL-2 R alpha is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 250 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro.
Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response.
Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients.
Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.
Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.
Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzì RM, Meliconi R
PloS one 2014;9(5):e96925
PloS one 2014;9(5):e96925
Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response.
Rose T, Pillet AH, Lavergne V, Tamarit B, Lenormand P, Rousselle JC, Namane A, Thèze J
The Journal of biological chemistry 2010 May 14;285(20):14898-14908
The Journal of biological chemistry 2010 May 14;285(20):14898-14908
Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients.
Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH
Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 15;182(12):7389-97
Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 15;182(12):7389-97
Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.
Zheng CF, Jones GJ, Shi M, Wiseman JC, Marr KJ, Berenger BM, Huston SM, Gill MJ, Krensky AM, Kubes P, Mody CH
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7221-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7221-9
Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.
Zheng CF, Jones GJ, Shi M, Wiseman JC, Marr KJ, Berenger BM, Huston SM, Gill MJ, Krensky AM, Kubes P, Mody CH
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7221-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7221-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by IL-2 and Neutralization by Human Common ? Chain/ IL-2 R? Antibody. Cell Proliferation Induced by IL-2 and Neutralization by Human Common ? Chain/ IL-2 R? Antibody.
